發(fā)布時間：2018-03-15 05:16

  本文選題：聚集誘導(dǎo)發(fā)光　切入點：自組裝　出處：《南昌大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：自2001年唐本忠院士課題組首先發(fā)現(xiàn)了一種聚集誘導(dǎo)發(fā)光(aggregation-induced emission,AIE)現(xiàn)象以來,國內(nèi)外許多科研工作者開展了大量的關(guān)于AIE材料發(fā)光機理及其應(yīng)用領(lǐng)域的研究。與傳統(tǒng)的聚集導(dǎo)致熒光猝滅的現(xiàn)象(aggregation-caused quenching,ACQ)相反,AIE發(fā)光材料在溶液中幾乎不發(fā)光或者發(fā)微弱光,而在聚集態(tài)或固態(tài)薄膜下能發(fā)出極強的熒光。AIE熒光團的發(fā)現(xiàn)為解決困擾已久的ACQ開創(chuàng)了一條新的路徑。截止目前,大量具有AIE性質(zhì)的熒光團被合成出來,并已經(jīng)廣泛地應(yīng)用于化學(xué)/生物傳感、細胞成像、有機發(fā)光二極管(OLED)等諸多領(lǐng)域。其中,基于AIE熒光小分子染料構(gòu)建熒光納米生物探針用于體細胞成像、療效檢測和癌癥治療已經(jīng)取得了突出的成就。然而,由于AIE染料的疏水性,導(dǎo)致其在生物領(lǐng)域中的應(yīng)用受到了一定程度的限制。因此,提高AIE染料的水溶性已經(jīng)吸引了諸多科學(xué)家的關(guān)注。兩親性高分子通過自組裝作用將疏水AIE染料包裹在高分子納米顆粒中,從而改善AIE染料的親水性問題。然而,AIE熒光團極易從高分子膠束中泄露出來,最終將影響其生物應(yīng)用的效率。通過化學(xué)反應(yīng),將具有良好生物相容性的高分子和AIE熒光團以化學(xué)共價鍵的方式結(jié)合制備熒光納米探針可以有效地解決熒光團泄露問題。此外,制備不同熒光發(fā)射波長的生物探針和構(gòu)建診療一體化平臺顯得十分重要。本文的研究工作主要是合成具有不同光學(xué)性質(zhì)(從藍光到近紅外光)和特殊官能團(氨基、醛基、羥基和雙鍵)修飾的AIE熒光小分子,通過不同的化學(xué)及高分子聚合方法(開環(huán)反應(yīng)、席夫堿、多組分一鍋法和氧化還原聚合、開環(huán)聚合)合成一系列具有穩(wěn)定結(jié)構(gòu)的AIE兩親性熒光高分子。由于熒光高分子具有兩親性,因此這些熒光高分子可以在水中自組裝形成了AIE熒光高分子納米顆粒。所制備的熒光納米顆粒具有很好的水分散性,極強的熒光性質(zhì)以及良好的生物相容性,在熒光標記細胞方面具有極好的用途。此外,將抗腫瘤藥物順鉑載帶在熒光納米顆粒表面,可以實現(xiàn)集成像和治療為一體納米診療平臺。
[Abstract]:Since 2001, Tang Benzhong Research Group first discovered a kind of agglomeration induced luminescence (AIEE) phenomenon. Many researchers at home and abroad have carried out a lot of research on the luminescence mechanism of AIE materials and their applications. Contrary to the phenomenon of aggregation leading to fluorescence quenching, AIE luminescent materials almost do not emit light or emit weak light in solution. However, the discovery of extremely strong fluorescence. AIE fluorescence groups in the aggregate or solid films has opened up a new path for solving the long-standing problem of ACQ. Up to now, a large number of fluorescent groups with the properties of AIE have been synthesized. It has been widely used in many fields, such as chemical / biological sensing, cell imaging, organic light-emitting diode (OLED), etc. Among them, fluorescent nano-biological probes were constructed based on AIE fluorescent small molecular dyes for somatic imaging. Curative effect testing and cancer treatment have made outstanding achievements. However, because of the hydrophobicity of AIE dye, its application in biological field is limited to a certain extent. Increasing the water solubility of AIE dyes has attracted the attention of many scientists. Amphiphilic polymers encapsulate hydrophobic AIE dyes in polymer nanoparticles through self-assembly. So as to improve the hydrophilicity of AIE dyes. However, the fluorescence group of AIE is easy to leak out from the macromolecule micelles, which will eventually affect the efficiency of its biological application. The preparation of fluorescent nanoprobes by combining polymer with AIE fluorescence groups with good biocompatibility by chemical covalent bonding can effectively solve the problem of fluorescence cluster leakage. It is very important to prepare biological probes with different emission wavelengths and to construct an integrated platform for diagnosis and treatment. In this paper, we mainly study the synthesis of special functional groups (amino, aldehyde groups) with different optical properties (from blue light to near infrared light). AIE fluorescent small molecules modified by hydroxyl groups and double bonds were polymerized by different chemical and polymeric methods (ring opening reaction, Schiff base, multicomponent one-pot polymerization and redox polymerization). A series of AIE amphiphilic fluorescent polymers with stable structure were synthesized by ring-opening polymerization. Therefore, these fluorescent polymers can self-assemble in water to form AIE fluorescent polymer nanoparticles, which have good water dispersion, strong fluorescence properties and good biocompatibility. In addition, the anti-tumor drug cisplatin on the surface of fluorescent nanoparticles can be integrated image and treatment as an integrated nano-diagnosis and treatment platform.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：O657.3

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