發(fā)布時(shí)間：2018-01-20 11:00

  本文關(guān)鍵詞： 樹枝狀大分子 酰胺化反應(yīng) 結(jié)構(gòu)修飾 PEG支鏈 3 5-二氨基苯甲酸 LCST 自組裝　出處：《西南科技大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：樹枝狀大分子(Dendrimer)是20世紀(jì)80年代蓬勃發(fā)展起來的一類經(jīng)有序組裝構(gòu)建的高度支化、結(jié)構(gòu)可控和單分散度的新型納米高分子。它們高度支化的結(jié)構(gòu)、獨(dú)特的單分散性及球形外形為這類化合物帶來一系列不同尋常的性質(zhì)和功能。例如:較大分子量、內(nèi)部具有廣闊空間、外圍(或稱表面)呈現(xiàn)極高密度官能團(tuán)等特點(diǎn)。目前對(duì)外圍(或稱表面)呈現(xiàn)極高密度官能團(tuán)的功能化的研究越來越受到重視,尤其在生物醫(yī)學(xué)、材料化學(xué)的應(yīng)用。本次實(shí)驗(yàn)中成功的合成出以3,5-二氨基苯甲酸為氨基酸基本單元的樹狀分子,并且對(duì)合成條件和過程進(jìn)行了探索和優(yōu)化、樹狀分子的溶液性質(zhì)的研究以及自組裝行為的探索等方面來全面研究該樹狀分子的性質(zhì)。經(jīng)過對(duì)合成條件的探索,成功找到中間體化合物的最佳合成條件是:n1:n2=1:2.5,反應(yīng)溫度為25℃,反應(yīng)時(shí)間20h,縮合試劑為EDCI與HOBT的組合;該樹狀分子具有較好的低臨界溶液溫度性質(zhì)(LCST),化合物親疏水性質(zhì)以及分子間非共價(jià)鍵作用對(duì)LCST性質(zhì)具有相關(guān);該樹狀分子在20%水和80%的二氯甲烷混合溶劑中,可以形成自組裝體;同時(shí)該樹狀分子可以形成凝膠并且具有較好的熱穩(wěn)定性,其最小化凝膠溶劑濃度為1.56%。
[Abstract]:Dendrimeris, a dendritic macromolecule, is a kind of highly branched structure constructed by ordered assembly, which flourished in 1980s. Novel nanopolymers with controllable structure and monodispersity. Their highly branched structures. The unique monodispersity and spherical shape bring about a series of unusual properties and functions for these compounds, such as large molecular weight and wide internal space. The periphery (or surface) is characterized by extremely high density functional groups. At present, more and more attention has been paid to the functionalization of the outer (or surface) very high density functional groups, especially in biomedicine. The application of material chemistry. In this experiment, we successfully synthesized the dendrimer with 3C5-diaminobenzoic acid as the basic unit of amino acid, and explored and optimized the synthetic conditions and process. The properties of the dendrimer were studied from the aspects of solution properties and self-assembly behavior. The synthetic conditions were explored. The optimum conditions for the synthesis of the intermediates are as follows: 1: n 1: n 2: 1: 2.5, the reaction temperature is 25 鈩，

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