【摘要】：環(huán)境中同時(shí)存在著多種重金屬元素,聯(lián)合暴露與單獨(dú)暴露時(shí),重金屬在體內(nèi)的蓄積分布情況也可能有所差異。為探究重金屬元素(汞、鉻、砷、鉛)對(duì)鎘(Cd)在體內(nèi)分布的影響,建立了大鼠在Cd暴露下的藥代動(dòng)力學(xué)(PBPK)模型,并進(jìn)行了包括Cd在內(nèi)5種重金屬的聯(lián)合毒性實(shí)驗(yàn),比較了Cd單獨(dú)給藥與重金屬混合物給藥2種方式下大鼠肝臟、腎臟中的Cd濃度水平。結(jié)果表明,聯(lián)合暴露高(Hg Cl23.67 mg·kg~(-1),NaAsO_2 3.67 mg·kg~(-1),CdCl_2 10.55 mg·kg~(-1),K_2Cr_2O_7 6.40 mg·kg~(-1),Pb(OOCCH_3)_2·3H_2O 133.33 mg·kg~(-1))、中(HgCl_20.367 mg·kg~(-1),NaAsO_2 0.367 mg·kg~(-1),CdCl_2 1.055 mg·kg~(-1),K2Cr2O70.640 mg·kg~(-1),Pb(OOCCH_3)_2·3H_2O 13.333 mg·kg~(-1))、低(HgCl_2 0.0367 mg·kg~(-1),Na As O20.0367 mg·kg~(-1),Cd Cl20.1055 mg·kg~(-1),K_2Cr_2O_7 0.0640 mg·kg~(-1),Pb(OOCCH3)2·3H2O 1.3333 mg·kg~(-1))劑量組大鼠肝臟中Cd濃度分別為13.37、0.78和0.06μg·g~(-1);腎臟中Cd濃度分別為14.41、1.64和0.15μg·g~(-1)。與對(duì)照組相比,暴露組中Cd濃度有顯著升高,且不同劑量組之間均有顯著性差異。同劑量Cd單獨(dú)暴露的PBPK模擬結(jié)果顯示,肝臟及腎臟中的Cd濃度水平落在聯(lián)合毒性實(shí)驗(yàn)結(jié)果的濃度范圍內(nèi),初步推斷其他4種重金屬的聯(lián)合暴露并沒有影響Cd在大鼠腎臟和肝臟中的濃度分布。
[Abstract]:There are many kinds of heavy metals in the environment, and the accumulation and distribution of heavy metals in the body may be different between the combined exposure and the single exposure. In order to investigate the effect of heavy metal elements (mercury, chromium, arsenic, lead) on the distribution of cadmium (Cd) in vivo, the pharmacokinetic (PBPK) model of rats exposed to Cd was established, and the joint toxicity experiments of five heavy metals, including Cd, were carried out. The concentrations of Cd in liver and kidney of rats were compared between Cd alone and heavy metal mixture. 緇撴灉琛ㄦ槑,鑱斿悎鏆撮湶楂，

本文編號(hào)：2218531