發(fā)布時間：2018-05-14 12:31

  本文選題：四溴雙酚A + -三溴苯酚　； 參考：《生態(tài)與農(nóng)村環(huán)境學(xué)報》2016年06期

【摘要】：為研究四溴雙酚A(TBBPA)及其降解產(chǎn)物2,4,6-三溴苯酚(TBP)對黃顙魚(Pelteobagrus fulvidraco)的內(nèi)分泌干擾毒性效應(yīng),在急性毒性試驗的基礎(chǔ)上開展黃顙魚幼體生長毒性試驗,分析黃顙魚的生長率并推導(dǎo)出TBBPA和TBP對黃顙魚28 d最低可觀察效應(yīng)濃度(MORC)和無可觀察效應(yīng)濃度(URC);利用酶聯(lián)免疫吸附(ELISA)試劑盒分析測定黃顙魚內(nèi)臟促腎上腺皮質(zhì)激素(ACTH)和卵黃蛋白原(VTG)含量,并進(jìn)行差異顯著性分析。結(jié)果表明,受試物的濃度和黃顙魚體重增長速率呈明顯的劑量-效應(yīng)關(guān)系,TBBPA對黃顙魚體重增長率的MORC和URC分別為0.32和0.16 mg·L~(-1),TBP對黃顙魚體重增長率的MORC和URC分別為0.64和0.32 mg·L~(-1),TBBPA較TBP具有更高的毒性。隨著TBBPA濃度的升高,黃顙魚內(nèi)臟中ACTH和VTG含量與對照相比總體呈上升趨勢。TBP對黃顙魚內(nèi)臟中VTG無顯著影響,但在其質(zhì)量濃度為0.64 mg·L~(-1)時可顯著降低ACTH含量。推測TBBPA和TBP是潛在的環(huán)境內(nèi)分泌干擾物。
[Abstract]:In order to study the endocrine-disrupting toxicity of tetrabromobisphenol A (TBBPA) and its degradation product, TBP2, to Pelteobagrus fulvidraco (Pelteobagrus fulvidraco), the growth toxicity test of Pelteobagrus fulvidracoides was carried out on the basis of acute toxicity test. The growth rate of Pelteobagrus fulvidraco was analyzed and the lowest observable effect concentration of TBBPA and TBP on Pseudobagrus fulvidraco for 28 days was deduced, and the lowest observable concentration (MORC) and the unobservable concentration of urcicum were derived. The Enzyme-linked Immunosorbent Assay kit was used to determine the adrenocorticotropic activity in the visceral adrenal cortex of Pelteobagrus fulvidraco. ACTH) and vitellogenin (VTG), The difference was analyzed. The results show that There was a significant dose-effect relationship between the concentration of the tested material and the growth rate of body weight of Pelteobagrus fulvidraco. The MORC and URC of TBBPA on the growth rate of body weight of Pelteobagrus fulvidraco were 0.32 and 0.16 mg / L respectively. The MORC and URC of TBBPA on the growth rate of body weight of Pelteobagrus fulvidraco were 0.64 and 0.32 mg / L respectively compared with TBP. Have higher toxicity. With the increase of TBBPA concentration, the contents of ACTH and VTG in the viscera of Pelteobagrus fulvidraco showed an increasing trend compared with the control. TBP had no significant effect on VTG in the viscera of Pelteobagrus fulvidracobagrus fulvidraco, but it could significantly decrease the content of ACTH at the concentration of 0.64 mg / L. It is assumed that TBBPA and TBP are potential environmental endocrine disruptors.
【作者單位】： 南京信息工程大學(xué)環(huán)境科學(xué)與工程學(xué)院;環(huán)境保護(hù)部南京環(huán)境科學(xué)研究所;
【基金】：江蘇省自然科學(xué)基金(BK20151100) 普通高校研究生科研創(chuàng)新計劃(KYLX15_0798)
【分類號】：X171.5
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本文編號：1887858