【摘要】：目的通過分析耐甲氧西林金黃色葡萄球菌(MRSA)及對甲氧西林敏感金黃色葡萄球菌(MSSA)的分布及耐藥性,為合理使用抗菌藥物提供科學依據。方法選取2013-2016年醫(yī)院臨床檢出分離并鑒定為金黃色葡萄球菌的細菌進行藥物敏感性試驗,根據其對甲氧西林敏感性分為MRSA和MSSA,分別對科室分布、標本來源及耐藥性進行分析。結果共分離出782株MRSA和491株MSSA,MRSA的檢出率占61.4%;MRSA和MSSA臨床科室主要分布在神經外科分別占23.6%、31.0%,ICU分別占19.8%、13.2%,呼吸內科分別占13.3%、5.7%;MRSA和MSSA主要來源于痰標本,分別占65.7%和42.6%;MRSA對萬古霉素、利奈唑胺、呋喃妥因、喹奴普汀/達福普汀的敏感率均95.00%,MSSA對苯唑西林、頭孢唑林、亞胺培南、利奈唑胺100.00%敏感,對青霉素G的耐藥率為94.1%。結論 MRSA對多種抗菌藥物有較高的耐藥性,MRSA耐藥性明顯大于MSSA,MSSA對大部分抗菌藥物仍保持較好的敏感性,臨床上應合理選用抗菌藥物。
[Abstract]:Objective to analyze the distribution and drug resistance of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) in order to provide scientific basis for the rational use of antimicrobial agents. Methods the bacteria isolated and identified as Staphylococcus aureus from 2013 to 2016 were selected for drug sensitivity test. According to their sensitivity to methicillin, they were divided into MRSA and MSSA, to analyze the distribution of departments, the origin of specimens and the drug resistance respectively. Results A total of 782 MRSA strains and 491 MSSA,MRSA strains were isolated. The main clinical departments of MRSA and MSSA were located in neurosurgery department (23.61.0%) and in ICU (19.813.2%). The major sources of MRSA and MSSA in respiratory department were sputum (65.7%) and MSSA (42.6%) for vancomycin, respectively. The sensitivities of linazolamine, furantoin, quinuptin / dafopudine were 95.00%. MSSA was sensitive to oxacillin, cefazolin, imipenem, and linazolamide 100.00%, and the resistance rate to penicillin G was 94.1%. Conclusion MRSA has higher drug resistance to many kinds of antimicrobial agents. MRSA is more sensitive than MSSA,MSSA to most antimicrobial agents, so it is necessary to select antibiotics reasonably in clinic.
【作者單位】： 寧波市第六醫(yī)院重癥醫(yī)學科;寧波市醫(yī)療中心李惠利醫(yī)院感染管理科;
【基金】：寧波市社會發(fā)展基金資助項目(2014C50047)
【分類號】：R446.5

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