本文選題：肌肉因子 + 骨代謝��； 參考：《中國體育科技》2017年06期

【摘要】：肌肉組織已經被認定為內分泌器官,其分泌的活性分子——"肌肉因子"備受關注。從早期胚胎發(fā)育到衰老或退化,肌肉和骨骼在形式和功能上都緊密相關,研究肌肉對骨骼的非機械力學作用越來越多。肌肉組織能分泌多種肌肉因子,包括IGF-1、FGF-2、Myostatin、Irisin、IL-6、IL-7、IL-15、BMPs、OGN、FAM5C等。這些分泌因子都對骨組織的各類細胞(如成骨細胞、破骨細胞和軟骨細胞)產生不同的作用。運動可以影響肌肉因子的表達水平,進而調控骨代謝。與年齡相關的肌肉衰減(Sarcopenia)和骨質疏松(Osteoporosis)是困擾老年人群健康的兩大問題。將肌肉和骨骼視為一個系統(tǒng),稱為肌骨系統(tǒng),并探討該系統(tǒng)內部的生物機制可能是解決這些問題的關鍵所在。進一步揭示肌肉因子介導肌肉和骨骼之間的"Crosstalk"的多條路徑,將為運動防治肌肉衰減和骨質疏松提供新的視角。
[Abstract]:Muscle tissue has been recognized as an endocrine organ and its active molecule, muscle factor, has attracted much attention. From early embryonic development to aging or degeneration, muscle and bone are closely related in form and function. Muscle tissue can secrete a variety of muscle factors, including IGF-1 FGF-2, Myostatin, IL-6, IL-7, IL-15, BMPs, OGNN, FAM5C, and so on. These secretory factors have different effects on various kinds of cells in bone tissue, such as osteoblasts, osteoclasts and chondrocytes. Exercise can affect the expression level of muscle factors, and then regulate bone metabolism. Age-related muscle attenuation (Sarcopenia) and osteoporosis (Osteoporosism) are two major health problems for the elderly. Consider muscle and bone as a system called musculoskeletal system and explore the biological mechanism within the system may be the key to solve these problems. Further revealing the multiple pathways of "Crosstalk" between muscle and bone mediated by muscle factors will provide a new perspective for the prevention and treatment of muscle attenuation and osteoporosis by exercise.
【作者單位】： 青少年健康評價與運動干預教育部重點實驗室;華東師范大學體育與健康學院;
【分類號】：G804.2;R87

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