發(fā)布時(shí)間：2018-03-04 01:25

  本文選題：純鎂　切入點(diǎn)：鎂合金　出處：《華南理工大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

【摘要】：鎂合金因其良好的生物相容性、生物降解性以及力學(xué)相容性等優(yōu)勢(shì)，是理想的新型可降解生物醫(yī)用金屬材料。但由于人體生理環(huán)境具有較強(qiáng)的侵蝕性，鎂合金植入后存在降解過(guò)快及一系列次生問(wèn)題，因此對(duì)鎂合金進(jìn)行生物降解控制具有重要意義。 本文以高純鎂（HP-Mg）和AZ91D鎂合金為研究對(duì)象，選取聚左乳酸（PLLA）以及分別以MgO和Mg(OH)_2為增強(qiáng)相的PLLA基復(fù)合材料為涂層材料，對(duì)醫(yī)用鎂合金可降解高分子材料基復(fù)合材料表面改性技術(shù)進(jìn)行了較為系統(tǒng)的探索研究。論文主要研究工作及結(jié)論如下： 首先，對(duì)PLLA有機(jī)溶劑進(jìn)行了篩選，從PLLA溶解速率、溶液涂覆效果（涂層均勻性、致密度及浸涂次數(shù)-涂層厚度函數(shù)關(guān)系）的角度優(yōu)選出最佳溶劑配方，即環(huán)氧氯丙烷與丙酮混合體積比為2:1的均勻混合物。 其次，利用項(xiàng)目組自有知識(shí)產(chǎn)權(quán)技術(shù)（發(fā)明專利申請(qǐng)?zhí)?01210320035.4），以涂層防護(hù)性能為主要考核指標(biāo)，實(shí)現(xiàn)了對(duì)PLLA濃度、浸涂次數(shù)和浸涂溫度等主要工藝參數(shù)的優(yōu)化；基于PLLA涂覆研究結(jié)果，對(duì)MgO/PLLA和Mg(OH)_2/PLLA復(fù)合材料涂覆技術(shù)進(jìn)行了較為系統(tǒng)的研究，探明了MgO和Mg(OH)_2添加量對(duì)涂覆效果尤其是涂層耐蝕性的影響規(guī)律，鎖定了其最佳添加量。 最后，，對(duì)典型試樣，包括陽(yáng)極極化處理前后的空白試樣，陽(yáng)極極化處理前后最佳涂覆工藝條件制備的1）PLLA涂層試樣、2）MgO/PLLA復(fù)合材料涂層試樣和3）Mg(OH)_2/PLLA復(fù)合材料涂層試樣進(jìn)行了綜合性能評(píng)價(jià)�；跍y(cè)試介質(zhì)顏色轉(zhuǎn)變的耐蝕性快速檢測(cè)、現(xiàn)代電化學(xué)動(dòng)電位極化曲線測(cè)試以及體外生物降解行為研究結(jié)果表明：1）適量MgO或Mg(OH)_2增強(qiáng)相的添加均能顯著提高PLLA涂層的降解防護(hù)性能；2）適量MgO或Mg(OH)_2增強(qiáng)相的添加有利于降低PLLA生物降解產(chǎn)生的酸化效應(yīng)；3）陽(yáng)極極化前處理有利于提高涂層的防護(hù)性能。涂層/基體結(jié)合力測(cè)試結(jié)果表明：1）涂覆狀態(tài)下，PLLA涂層、MgO/PLLA和Mg(OH)_2/PLLA復(fù)合材料涂層與基體的結(jié)合力無(wú)明顯差異，但陽(yáng)極極化前處理對(duì)增強(qiáng)涂層/基體結(jié)合力有益；2）體外生物降解測(cè)試期間，復(fù)合材料涂層與基體的結(jié)合力遠(yuǎn)優(yōu)于PLLA涂層。SEM分析結(jié)果表明：PLLA涂層及PLLA基復(fù)合材料涂層厚度均勻，結(jié)構(gòu)致密。
[Abstract]:Magnesium alloy is an ideal new biodegradable biomedical material because of its good biocompatibility, biodegradability and mechanical compatibility. The degradation of magnesium alloy is too fast and a series of secondary problems exist after implantation, so it is very important to control the biodegradation of magnesium alloy. In this paper, high purity magnesium (HP-Mg) and AZ91D magnesium alloys were studied. Poly (L-lactic acid) and PLLA matrix composites with MgO and Mg(OH)_2 as reinforcing phases were selected as coating materials. The surface modification technology of medical magnesium alloy degradable polymer composites was studied systematically. The main research work and conclusions are as follows:. Firstly, the PLLA organic solvent was screened, and the optimum solvent formulation was selected from the angles of PLLA dissolution rate, solution coating effect (coating uniformity, density and the relationship between coating thickness and density). That is, the mixed volume ratio of epichlorohydrin and acetone is 2: 1. Secondly, using the intellectual property technology of the project group (invention patent application no. 201210320035.4) and taking the protective performance of the coating as the main evaluation index, the main technological parameters such as PLLA concentration, times and temperature of the coating are optimized. Based on the results of PLLA coating, the coating technology of MgO/PLLA and Mg(OH)_2/PLLA composites was systematically studied. The effect of the amount of MgO and Mg(OH)_2 on the coating effect, especially the corrosion resistance of the coating, was investigated, and the optimum amount of the coating was locked out. Finally, for typical samples, including blank samples before and after anodic polarization treatment, The comprehensive properties of the 1D PLLA / PLLA composite coating sample and the 3Mg-OHH + 2 / PLLA composite coating sample prepared under the optimum coating conditions before and after anodic polarization treatment were evaluated. Based on the rapid corrosion resistance test of the color transformation of the medium, the corrosion resistance of the coated sample was evaluated. The results of modern electrochemical potentiodynamic polarization curve test and biodegradation behavior in vitro showed that the addition of appropriate amount of MgO or Mg(OH)_2 reinforcements could significantly improve the protective performance of PLLA coatings on degradation and degradation. The addition of appropriate amount of MgO or Mg(OH)_2 reinforcements could significantly improve the degradation protection performance of PLLA coatings. Anodic pretreatment can improve the protective performance of the coating. The results of coating / substrate adhesion test show that the coating is coated with MgO / PLLA and Mg(OH)_2/PLLA composite coatings under the condition of 1: 1). There was no significant difference in adhesion with the matrix. However, during the in vitro biodegradation test, the adhesion between composite coating and substrate was much better than that of PLLA coating. The results showed that the thickness of PLLA coating and PLLA matrix composite coating were uniform. The structure is compact.
【學(xué)位授予單位】：華南理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：TG174.46

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