本文選題：事件相關(guān)電位 + 計(jì)算加工�。� 參考：《華中科技大學(xué)》2009年碩士論文

【摘要】：【研究背景】 計(jì)算是人們?nèi)粘Ｉ钪凶钪匾乃季S活動(dòng)之一,涉及了多種認(rèn)知加工環(huán)節(jié),如感知覺(jué)、判斷、比較和推理等,能比較深入地反映個(gè)體的腦認(rèn)知水平。計(jì)算能力與個(gè)體的智商水平亦密切相關(guān),也是智力測(cè)驗(yàn)的重要測(cè)查內(nèi)容,如中國(guó)修訂韋氏成人智力量表(WAIS-RC)中即包括算術(shù)、數(shù)字廣度和數(shù)字符號(hào)三個(gè)分測(cè)驗(yàn)。計(jì)算能力下降是顱腦外傷的傷者在臨床就診及法醫(yī)學(xué)鑒定時(shí)的常見(jiàn)表現(xiàn)和主訴之一,可對(duì)傷者的日常生活、職業(yè)勞動(dòng)及社會(huì)交往造成嚴(yán)重影響,客觀評(píng)定計(jì)算能力的受損程度對(duì)于評(píng)價(jià)腦外傷后智能障礙的嚴(yán)重程度具有重要意義。目前,計(jì)算能力的檢測(cè)一般通過(guò)提問(wèn)、心算和筆算等方式來(lái)完成,這些檢查方法均依賴于被試的主動(dòng)性與合作程度。法醫(yī)學(xué)鑒定時(shí),傷者受軀體情況、賠償心理和精神狀態(tài)等因素的影響,往往配合性較差,測(cè)驗(yàn)結(jié)果常與其傷后的實(shí)際能力水平不相符,限制了WAIS-RC等神經(jīng)心理學(xué)測(cè)驗(yàn)技術(shù)在法醫(yī)學(xué)領(lǐng)域的應(yīng)用價(jià)值。因此,建立符合法醫(yī)學(xué)鑒定工作需要的計(jì)算能力客觀檢測(cè)方法具有重要的實(shí)用性和現(xiàn)實(shí)意義。 事件相關(guān)電位(event-related potential, ERP)是用于檢測(cè)認(rèn)知加工過(guò)程中腦活動(dòng)的一種無(wú)創(chuàng)性檢測(cè)方法,記錄到的瞬間電勢(shì)變化與刺激(如一個(gè)詞、一種聲音或者一個(gè)圖像等)的發(fā)生有鎖時(shí)關(guān)系,具有很高的時(shí)間分辨率。近年來(lái),一些研究者嘗試采用ERP技術(shù)來(lái)探索數(shù)量加工的電生理機(jī)制、運(yùn)算能力的發(fā)展機(jī)制,并發(fā)現(xiàn)了一些與數(shù)字加工有關(guān)的特異性ERP成分,但在法醫(yī)學(xué)領(lǐng)域應(yīng)用ERP技術(shù)來(lái)評(píng)估計(jì)算加工能力在國(guó)內(nèi)外均未見(jiàn)文獻(xiàn)報(bào)道。本研究嘗試建立符合臨床法醫(yī)學(xué)鑒定及ERP檢測(cè)要求的計(jì)算加工刺激范式,探索計(jì)算加工相關(guān)的特異性ERP成分,以期為顱腦外傷后計(jì)算能力障礙的檢測(cè)提供客觀的電生理參考指標(biāo)。 【目的】采用后續(xù)判斷比較任務(wù)范式(算式圖片與答案圖片間隔呈現(xiàn)),編制包含加、減、乘、除運(yùn)算的算術(shù)刺激序列進(jìn)行檢測(cè),比較健康志愿者與顱腦外傷志愿者所誘發(fā)的ERP成分的特征和差異,并探討ERP各成分與WAIS-RC檢測(cè)結(jié)果的相關(guān)性。 【方法】利用37導(dǎo)Neuroscan ERP儀器對(duì)46例正常志愿者(對(duì)照組)以及11例重型顱腦外傷志愿者(外傷組)分別進(jìn)行聽(tīng)覺(jué)Oddball范式、計(jì)算加工后續(xù)判斷比較任務(wù)范式的ERP檢測(cè)及WAIS-RC測(cè)驗(yàn),分別比較與計(jì)算加工相關(guān)的ERP各成分的波幅和潛伏期、頭皮分布特征及其與經(jīng)典聽(tīng)覺(jué)P300成分和WAIS-RC測(cè)驗(yàn)結(jié)果的相關(guān)性。 【結(jié)果】 1.外傷組WAIS-RC各分測(cè)驗(yàn)的粗分、量表分、言語(yǔ)智商、操作智商及總智商的均值均明顯低于對(duì)照組,有極顯著差異(P㩳0.01); 2.外傷組聽(tīng)覺(jué)P300分化欠佳,潛伏期較對(duì)照組延長(zhǎng),且波幅較低,N2潛伏期與對(duì)照組比較有顯著性差異(P㩳0.05),P3波幅和潛伏期也有極顯著差異(P㩳0.01); 3.計(jì)算加工范式的刺激呈現(xiàn)后頂枕部各記錄點(diǎn)(CZ、P3、P4等)可獲得分化明顯ERP波形,其中最穩(wěn)定的記錄點(diǎn)在CZ點(diǎn); 4.不同性別被試的計(jì)算加工ERP波形各成分波幅、潛伏期均無(wú)顯著性差異; 5.對(duì)照組檢測(cè)發(fā)現(xiàn)算式、正確結(jié)果,錯(cuò)誤結(jié)果三種刺激均可引出相似波形,該波形由n1、p2、n2和p3四個(gè)子成分構(gòu)成。正確結(jié)果引出波形中p2、n2子成分較錯(cuò)誤結(jié)果波形分化差,算式引出波形中n2、p3子成分較錯(cuò)誤結(jié)果分化差。錯(cuò)誤結(jié)果波形p2、n2、p3的潛伏期較正確結(jié)果延長(zhǎng),差異有極顯著性(P0.01)。錯(cuò)誤結(jié)果的n2、p3的潛伏期較算式延長(zhǎng),差異有顯著性(P0.05);算式的n2、p3的潛伏期較正確結(jié)果延長(zhǎng),差異有顯著性(P0.05); 6.外傷組各刺激引出的波形與對(duì)照組相似,波形分化較對(duì)照組差。各成分波幅均比對(duì)照組明顯降低,尤其正確結(jié)果和錯(cuò)誤結(jié)果的p3波幅明顯降低,差異有極顯著性(P0.01),各成分潛伏期與對(duì)照組相比均有延長(zhǎng),其中正確結(jié)果的n2、p3潛伏期的差異在兩組有極顯著性(P0.01),錯(cuò)誤結(jié)果的和算式的p2潛伏期在兩組也有極顯著差異,算式的p3潛伏期在兩組有極顯著差異; 7.計(jì)算錯(cuò)誤結(jié)果引出的p3潛伏期與總智商呈明顯負(fù)相關(guān)(r=-0.44,P㩳0.01),高于聽(tīng)覺(jué)靶刺激誘發(fā)的p3潛伏期與總智商的相關(guān)程度; 8.采用聽(tīng)覺(jué)P300潛伏期推斷智商模型只能解釋智商變異的5%,單獨(dú)納入計(jì)算錯(cuò)誤結(jié)果P3潛伏期指標(biāo)推斷智商模型能解釋智商變異的17.2%;聯(lián)合視覺(jué)P300和計(jì)算錯(cuò)誤結(jié)果p3指標(biāo)則可以解釋智商變異的18.8%。 【結(jié)論】計(jì)算加工刺激序列可誘發(fā)穩(wěn)定的ERP成分,算式、正確結(jié)果,錯(cuò)誤結(jié)果三種刺激所引出p3的波幅和潛伏期與計(jì)算加工能力密切相關(guān),即計(jì)算能力越差,p3的潛伏期越長(zhǎng),波幅越小;該成分以頂枕部的記錄點(diǎn)(Cz點(diǎn))記錄可靠。其中計(jì)算錯(cuò)誤結(jié)果引出的p3潛伏期與WAIS-RC總智商呈明顯負(fù)相關(guān),高于聽(tīng)覺(jué)靶刺激誘發(fā)的p3潛伏期與總智商的相關(guān)程度,采用計(jì)算加工ERP刺激范式來(lái)檢測(cè)顱腦損傷后的認(rèn)知功能障礙比聽(tīng)覺(jué)Oddball范式引出P300更為準(zhǔn)確,具有一定法醫(yī)學(xué)應(yīng)用價(jià)值。
[Abstract]:[research background]
Calculation is one of the most important thinking activities in people's daily life. It involves a variety of cognitive processing links, such as perception, judgment, comparison and reasoning, which can reflect the level of individual brain cognition. The calculation ability is closely related to the intelligence quotient level of the individual, and it is also an important survey content of the intelligence test, such as the Chinese Revision of Wechsler's formation. The human intelligence scale (WAIS-RC) consists of three subtests including arithmetic, digital breadth and digital symbol. The decline of computational ability is one of the common manifestations and complaints in the clinical and forensic identification of the traumatic brain injury. It can have a serious impact on the daily life, occupational labor and social interaction of the injured, and objectively assess the calculation ability. The degree of loss is of great significance for evaluating the severity of mental disorders after brain injury. At present, the detection of the ability of the brain is usually done by asking questions, mental calculation and writing, all of which depend on the initiative and degree of cooperation of the subjects. In forensic identification, the injured are subject to physical condition, compensation for psychological and mental state, etc. The effect of the hormone is often poor, and the result of the test is often not consistent with the actual level after the injury. It restricts the application value of WAIS-RC and other neuropsychological test techniques in the field of forensic medicine. Therefore, it is of great practical and practical significance to establish the objective testing method of computational ability in accordance with the forensic identification work.
Event-related potential (ERP) is a noninvasive detection method used to detect brain activity during cognitive processing. The transient potential changes recorded by the event have a lock time relationship with the occurrence of stimuli (such as a word, a sound or an image, etc.), with a high time resolution. In recent years, some researchers have tried. ERP technology is used to explore the electrophysiological mechanism of quantitative processing, the development mechanism of operational ability, and some specific ERP components related to digital processing, but the application of ERP technology in the field of forensic medicine to evaluate the computational processing ability is not reported at home and abroad. In order to provide an objective electrophysiological reference index for the detection of the impairment of computational ability after craniocerebral trauma, the required computational processing stimulus paradigm was measured to explore the specific ERP components related to calculation and processing.
[Objective] to use the follow-up judgment to compare the task paradigm (the interval between the calculated picture and the answer picture), to compile the arithmetic stimulus sequence including addition, subtraction, multiplication and operation, to compare the characteristics and differences of ERP components induced by healthy volunteers and craniocerebral trauma volunteers, and to explore the correlation between the components of ERP and the results of WAIS-RC detection.
[Methods] the auditory Oddball paradigm was performed on 46 normal volunteers (control group) and 11 cases of severe craniocerebral trauma volunteers (trauma group) with 37 Neuroscan ERP instruments. The ERP detection and WAIS-RC test of the task paradigm were calculated, and the amplitude and latency of each component of ERP related to processing were compared. Distribution of scalp and its correlation with classical auditory P300 components and WAIS-RC test results.
[results]
1. the scores of gross scores, scores of verbal IQ, IQ and total IQ of WAIS-RC in each group were significantly lower than those in the control group (P? 0.01).
2. of the trauma group, the auditory P300 was poorly differentiated, the latency was longer than the control group, and the amplitude was lower. The latency of N2 was significantly different from the control group (P? 0.05), and the amplitude and latency of P3 were also significantly different (P? 0.01).
3. after calculating the stimulus presentation of the processing paradigm, the dominant occipital recording points (CZ, P3, P4, etc.) can get the obvious ERP waveform, and the most stable recording point is at CZ point.
4. there was no significant difference in the amplitude of each component in the ERP waveform calculated by different gender subjects.
5. control group detection formula, correct results, error results can lead to three kinds of stimulation can lead to the similar waveform, the waveform consists of N1, P2, N2 and P3 four components. The correct results lead to the waveform P2, N2 sub component than the wrong result waveform differentiation, the formula leads to the waveform N2, the P3 sub component is worse than the error results. Error results waveform P2, N2, P3. The incubation period was longer than that of the correct result (P0.01). The latency of N2 in the wrong result was longer than that of the calculation formula (P0.05), and the latency of N2 and P3 was longer than that of the correct result (P0.05).
6. the waveform of each stimulus in the trauma group was similar to the control group, and the waveform differentiation was worse than the control group. The amplitude of each component was significantly lower than the control group. The P3 amplitude of the correct results and the wrong results was significantly reduced, and the difference was very significant (P0.01). The latent period of each component was prolonged compared with the control group, of which the correct results were in the N2, P3 incubation period. The difference between the two groups was very significant (P0.01), and the P2 latency of the error results and the calculating formula also showed significant difference in the two groups, and the P3 latency of the calculation formula was very significant in the two groups.
7. the P3 latency was negatively correlated with the total IQ (r=-0.44, P? 0.01), which was higher than that induced by auditory target stimulation and the degree of correlation between the latency of P3 and the total IQ.
8. using the auditory P300 latency infer that the IQ model can only explain 5% of the IQ variation, and separate the calculated error results from the P3 latency index to infer that the IQ model can explain the IQ variation by 17.2%; the combined visual P300 and the calculated error results can explain the 18.8%. of the IQ variation.
[Conclusion] the calculated processing stimulation sequence can induce stable ERP components, calculation formula, correct results, and error results of three stimuli. The amplitude and latency of P3 are closely related to the calculation and processing ability. That is, the worse the computational ability, the longer the P3 latency is, the smaller the amplitude; the composition is reliable with the record point of the top pillow (Cz point). Among them, the calculation error is wrong. The P3 latency caused by false results is negatively correlated with the total IQ of WAIS-RC. It is higher than the correlation between the latency of P3 induced by auditory target stimulation and the total IQ. It is more accurate to use the calculated ERP stimulation paradigm to detect the cognitive impairment after brain injury than that of the auditory Oddball paradigm, which is of certain forensic application value.

【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2009
【分類號(hào)】：D919

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6 王杰審計(jì)署駐濟(jì)南特派辦計(jì)算機(jī)審計(jì)處;ERP系統(tǒng)審計(jì)應(yīng)用的幾點(diǎn)思考[N];中國(guó)審計(jì)報(bào);2009年

7 沈俊杰;ERP預(yù)算規(guī)劃初探[N];中國(guó)冶金報(bào);2009年

8 羅瓊;勘探南方ERP系統(tǒng)正式上線[N];中國(guó)石化報(bào);2008年

9 彭敏;中小企業(yè)ERP：告別悲觀 理性成長(zhǎng)[N];電腦商報(bào);2008年

10 記者阮緒波;公司ERP系統(tǒng)全面上線運(yùn)行[N];華北電力報(bào);2009年

相關(guān)博士學(xué)位論文 前10條

1 楊智勇;ERP實(shí)施評(píng)價(jià)若干問(wèn)題研究[D];天津大學(xué);2009年

2 方安儒;面向中國(guó)企業(yè)ERP系統(tǒng)應(yīng)用的實(shí)證研究[D];哈爾濱工業(yè)大學(xué);2010年

3 代碧波;企業(yè)ERP實(shí)施知識(shí)管理績(jī)效評(píng)價(jià)研究[D];哈爾濱工程大學(xué);2012年

4 李玲;煤礦企業(yè)ERP模式研究[D];遼寧工程技術(shù)大學(xué);2010年

5 尹剛;多事件ERP成份分解算法研究及應(yīng)用[D];電子科技大學(xué);2010年

6 崔樹(shù)杰;基于ERP系統(tǒng)的我國(guó)石油供應(yīng)鏈成本管理問(wèn)題研究[D];北京交通大學(xué);2011年

7 祁凱;面向制造業(yè)ERP的企業(yè)建模研究[D];哈爾濱理工大學(xué);2011年

8 唐佩雄;基于平衡計(jì)分卡的決策支持系統(tǒng)研究[D];暨南大學(xué);2009年

9 車穎;計(jì)算無(wú)關(guān)模型驅(qū)動(dòng)的ERP系統(tǒng)重構(gòu)關(guān)鍵技術(shù)研究[D];哈爾濱工業(yè)大學(xué);2011年

10 曹碧華;數(shù)字及其單位加工的發(fā)展和ERP研究[D];西南大學(xué);2012年

相關(guān)碩士學(xué)位論文 前10條

1 吳靜銘;計(jì)算加工ERP在法醫(yī)學(xué)鑒定中的初步研究[D];華中科技大學(xué);2009年

2 吳靜銘;計(jì)算加工ERP在法醫(yī)學(xué)鑒定中的初步研究[D];華中科技大學(xué);2009年

3 吳海軍;企業(yè)ERP系統(tǒng)實(shí)施效益預(yù)評(píng)估[D];北京郵電大學(xué);2010年

4 宋培坤;制造企業(yè)ERP實(shí)施過(guò)程研究[D];天津大學(xué);2010年

5 趙宇;ERP系統(tǒng)在遼寧出版集團(tuán)出版管理中的整合應(yīng)用[D];電子科技大學(xué);2010年

6 馮建軍;人力資源管理系統(tǒng)在ERP中的實(shí)施與應(yīng)用[D];電子科技大學(xué);2009年

7 徐哲;曙光公司ERP系統(tǒng)應(yīng)用分析[D];東北大學(xué);2008年

8 劉兆軍;ERP軟件實(shí)施中的會(huì)計(jì)業(yè)務(wù)流程重組研究[D];東北大學(xué);2007年

9 榮芳;石化企業(yè)ERP項(xiàng)目的風(fēng)險(xiǎn)管理研究[D];中國(guó)海洋大學(xué);2009年

10 郭欣;大型石化企業(yè)電子商務(wù)與ERP集成的實(shí)踐與探索[D];天津大學(xué);2010年

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