本文選題：N-(-甲氧基羰基--甲基丙基)--(-氟戊基)吲唑--甲酰胺 + 合成大麻素��； 參考：《藥學(xué)學(xué)報(bào)》2017年11期

【摘要】：本文研究新型毒品5F-AMB在體外肝微粒體模型中的代謝物。在體外人肝微粒體孵育模型中加入5F-AMB以模擬在人體的代謝過程,并利用超高效液相色譜高分辨質(zhì)譜聯(lián)用技術(shù)(UPLC-HR-MS)分析代謝發(fā)生位點(diǎn)及代謝途徑。結(jié)果顯示,5F-AMB在人肝微粒體模型中共產(chǎn)生9種代謝物,其主要代謝途徑為酯鍵水解、酯鍵水解合并脫氟氧化、酯鍵水解合并戊烷基鏈羥化和酯鍵水解合并吲唑環(huán)羥化。以上結(jié)果表明該方法簡便快捷,推薦5F-AMB的酯鍵水解、酯鍵水解合并脫氟氧化、酯鍵水解合并戊烷基鏈羥化和酯鍵水解合并吲唑環(huán)羥化代謝物為合適的潛在尿液標(biāo)志物。
[Abstract]:The metabolites of new drug 5F-AMB in vitro liver microsomal model were studied.5F-AMB was added to human liver microsomal incubation model in vitro to simulate the metabolic process in human body. UPLC-HR-MS was used to analyze the metabolic sites and pathways.The results showed that 9 metabolites were produced in human liver microsomal model. The main metabolic pathways were ester bond hydrolysis, ester bond hydrolysis combined with defluorination, ester bond hydrolysis combined with pentane chain hydroxylation and ester bond hydrolysis combined with indazole hydroxylation.The results show that this method is simple and fast. It is recommended that the hydrolysis of ester bond, hydrolysis of ester bond combined with defluorination, hydrolysis of ester bond combined with hydroxylation of pentane chain and hydrolysis of ester bond combined with indazole cyclohydroxylation metabolite are suitable potential urine markers.
【作者單位】： 公安部禁毒情報(bào)技術(shù)中心;
【基金】：國家重點(diǎn)研究與發(fā)展計(jì)劃資助項(xiàng)目(2016YFC0800903)
【分類號(hào)】：D919.4
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本文編號(hào)：1743308