本文關(guān)鍵詞： 局部腦血流 發(fā)射型計(jì)算機(jī) 測(cè)謊 ECD SPM　出處：《中國醫(yī)科大學(xué)》2010年碩士論文　論文類型：學(xué)位論文

【摘要】： 前言 在司法實(shí)踐中,犯罪嫌疑人(被告人)的供述、當(dāng)事人的陳述以及證人證言等主觀證據(jù)缺少相應(yīng)證據(jù)鏈條證明時(shí),通過測(cè)謊技術(shù)來證明這些主觀證據(jù)是否真實(shí)可信是至關(guān)重要的。但由于目前的測(cè)謊技術(shù)主要依靠多道生理記錄儀,根據(jù)心電、血壓、呼吸、皮膚電阻等植物神經(jīng)反應(yīng)的生理指標(biāo)間接判定被檢者是否說謊,存在假陽性或假陰性結(jié)果,其測(cè)試結(jié)果在司法訴訟中不能作為鑒定結(jié)論直接應(yīng)用。因此,確定在說謊狀態(tài)下大腦功能區(qū)的改變對(duì)今后解決測(cè)謊問題起著重要作用。 SPECT是用其具有專門探測(cè)核射線的探頭,探測(cè)體內(nèi)放射性物質(zhì)(核素藥物99mTc)的分布狀況來進(jìn)行檢查,可以觀察大腦在思維活動(dòng)時(shí)的功能區(qū)變化狀況。 本研究通過對(duì)15名受試者進(jìn)行SPECT腦功能掃描,進(jìn)而研究其在說謊與說真話狀態(tài)下腦功能區(qū)改變的不同,旨在分析說謊狀態(tài)下的神經(jīng)網(wǎng)絡(luò)。 試驗(yàn)對(duì)象與方法 一、試驗(yàn)對(duì)象 15名健康志愿者,均為右利手,男性,年齡23-28歲。所有受檢者均無精神與神經(jīng)系統(tǒng)疾病及相關(guān)病史。志愿者均在詳細(xì)了解本研究目的、內(nèi)容及步驟后自愿接受檢查。 二、試驗(yàn)方法 15名被試者每人共測(cè)3次(即靜息狀態(tài)下掃描,說真話狀態(tài)下掃描與說謊狀態(tài)下掃描),分3天進(jìn)行。每次在注藥后進(jìn)行ECT掃描,同時(shí)提問問題。問題：你母親姓什么?回答：如姓“李”(說真話)或姓“張”(說假話)。試驗(yàn)完畢后進(jìn)行確認(rèn)。具體步驟如下： 1、第一次(靜息狀態(tài)下掃描) 被試者建立靜脈通道,身體放松仰臥在掃描床上。讓被試者閉目休息,消除雜慮。靜息5分鐘開始注藥,并進(jìn)行ECT掃描。 2、第二次(說真話狀態(tài)下掃描) 被試者建立靜脈通道,身體放松仰臥在掃描床上。讓被試者閉目休息,消除雜慮。靜息5分鐘開始注藥,并進(jìn)行ECT掃描,同時(shí)提問問題。被試者即刻回答(說真話)問題。 3、第三次(說謊狀態(tài)下掃描) 被試者建立靜脈通道,身體放松仰臥在掃描床上。讓被試者閉目休息,消除雜慮。靜息5分鐘開始注藥,并進(jìn)行ECT掃描,同時(shí)提問問題。被試者即刻回答(說假話)問題。三、參數(shù)設(shè)計(jì) 采集矩陣：128×128,能峰：140keV,窗寬：±20%。采集模式：ZOOM：1.45,探頭各旋轉(zhuǎn)1800,5.6／幀,每幀采集25s,共采集64幀影像,采集時(shí)間共約需30min。統(tǒng)計(jì)學(xué)處理——SPM分析：本研究采用SPM2 (SPM2, Wollcome Department of Cognitive Neurology, London, UK)分析腦功能區(qū)變化。分析過程包括圖像轉(zhuǎn)化、圖像標(biāo)準(zhǔn)化、統(tǒng)計(jì)學(xué)分析和顯著性評(píng)估4個(gè)主要步驟。通過SPM2軟件將所有SPECT橫斷面圖像轉(zhuǎn)換成analysis7格式,在MATLAB6.1平臺(tái)上,應(yīng)用SPM2對(duì)圖像進(jìn)行處理和數(shù)據(jù)分析。首先,按SPM程序內(nèi)自帶的SPECT模板進(jìn)行圖像歸一化處理,以平均局部腦血流55ml／100ml／min水平進(jìn)行歸一化,得到調(diào)整過的腦功能區(qū)激活圖像,使之與Talairach的空間坐標(biāo)對(duì)應(yīng)。我們將調(diào)整過的數(shù)據(jù)進(jìn)行比較,即可得到一系列由數(shù)值構(gòu)成的t統(tǒng)計(jì)參數(shù)圖SPM{t},(體素差異閾值設(shè)定為10),然后將SPM{t}圖轉(zhuǎn)換成標(biāo)準(zhǔn)正態(tài)分布的Z參數(shù)圖SPM{Z},SPM{Z}上的每一個(gè)顯著差異均是通過對(duì)數(shù)據(jù)進(jìn)行t檢驗(yàn)(p=0.05)來評(píng)估的。再根據(jù)Talairach圖譜投射到相應(yīng)的大腦區(qū)域,即得到說謊時(shí)大腦的激活區(qū)。 結(jié)果 在說謊狀態(tài)下枕回、島葉、中顳葉、額中回、扣帶前回、海馬及小腦的放射性分布明顯升高。 結(jié)論 確認(rèn)說謊的腦功能區(qū)為枕回、島葉、中顳葉、額中回、扣帶前回、海馬及小腦。
[Abstract]:Preface
In judicial practice, criminal suspects (the defendant)'s testimony, statements of the parties and witness testimony and other evidence of the lack of corresponding subjective evidence chain that, through the polygraph test to prove the subjective evidence is authentic is critical. But because of the polygraph technology currently rely mainly on the polygraph, according to ECG, blood pressure, breathing skin resistance and other physiological indexes, the autonomic responses were seized indirectly determine whether there lies, false positive or false negative results, the test results in judicial proceedings can not be directly used as conclusions. Therefore, to determine the brain function in the area lying under the change in the future to solve the problem of lie detection plays an important role.
SPECT is used to detect the distribution of radioactive substances in the body (nuclide drug 99mTc) with its special probe to detect nuclear radiation. It can observe the changes of the brain in the functional area when thinking.
In this study, 15 subjects were scanned by SPECT brain function, and then studied the difference of brain functional areas in lying and telling the truth, aiming at analyzing the neural network under the condition of lying.
Test object and method
First, the test object
15 healthy volunteers were all right-handed men. The age of the male was 23-28 years old. All the subjects had no mental and neurological diseases or related medical history. Volunteers volunteered to know the purpose, contents and steps of the study.
Two, test method
15 subjects were measured 3 times per person (i.e. resting state scan, said scanning and lying truth under scanning), conducted in 3 days. Every time after injection ECT scan, and ask questions. Question: your mother's surname what? Answer: as the name "Li" (to tell the truth) or Zhang (lie). The test was confirmed after the specific steps are as follows:
1, first (resting state scan)
The subjects set up the venous channel, the body relaxed on the scan bed. Let the subjects close their eyes and eliminate miscellaneous concerns. Take 5 minutes to start the drug injection and carry out a ECT scan.
2, second times (when the truth is scanned)
The subjects set up venous access, and their body relaxed and supine on the scanning bed. Let subjects closed their eyes and rest to eliminate miscellaneous concerns. After 5 minutes of rest, drug injection was started, and ECT scan was performed. Meanwhile, questions were asked.
3, third (scans in the state of lying)
The subjects set up the venous channel, and the body relaxed and supine on the scanning bed. Let the subjects shut their eyes to rest and eliminate miscellaneous concerns. After 5 minutes of rest, drug injection was started, and ECT scan was performed. Meanwhile, questions were asked. Subjects answered questions immediately. (three) parameter design.
Collection: 128 * 128 matrix, the peak: 140keV, window width: + 20%. acquisition mode: ZOOM:1.45, probe the rotation of 1800,5.6 / frames, each frame acquisition 25s, were collected from 64 images, a total acquisition time is about SPM analysis of 30min. statistical analysis: This study adopts SPM2 (SPM2, Wollcome Department of Cognitive Neurology London, UK), analysis of the changes of brain function area. The analysis process including image conversion, image normalization, statistical analysis and significant assessment of 4 main steps. Through the SPM2 software will be all SPECT cross-sectional images into analysis7 format on the MATLAB6.1 platform, using SPM2 for image processing and data analysis. Firstly, according to the the SPM program included in the SPECT template image is normalized, normalized to the average local cerebral blood flow of 55ml / 100ml / min levels, activation of brain function area image adjustment, and make the Talairach The space coordinates. We compare the adjusted data can be obtained by a series of numerical components of the T statistical parameter map SPM{t} (voxel difference threshold value is 10), then convert SPM{t} drawings into Z parameter map SPM{Z} standard normal distribution, a significant difference is SPM{Z} the t test was performed on the data (p=0.05) to evaluate. According to the Talairach map projected onto the corresponding brain regions, to obtain the activation areas of the brain. When lying
Result
The radiological distribution of the hippocampus and cerebellum was significantly increased in the occipital gyrus, the insula, the middle temporal lobe, the middle frontal gyrus, the anterior cingulate gyrus, and the cerebellum.
conclusion
It is confirmed that the brain function area of lying is occipital gyrus, insula, meso temporal lobe, middle frontal gyrus, anterior cingulate gyrus, hippocampus and cerebellum.

【學(xué)位授予單位】：中國醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：D918.2

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