【摘要】：目的觀察丹芪祛瘀止痛顆粒治療氣虛血瘀型胃癌前病變患者的臨床療效及可能作用機(jī)制。方法將68例氣虛血瘀型胃癌前病變患者隨機(jī)分為治療組和對(duì)照組各34例。治療組給予丹芪祛瘀止痛顆粒,每次10g,每天3次。對(duì)照組給予維酶素片,每次0.8 g,每天3次。兩組療程均為3個(gè)月。治療后評(píng)價(jià)臨床療效,治療前后分別對(duì)患者中醫(yī)癥狀、胃黏膜組織病理進(jìn)行評(píng)分,并檢測(cè)胃黏膜組織中腫瘤壞死因子受體相關(guān)因子1(TRAF1)、淋巴細(xì)胞活化誘導(dǎo)受體(4-1BB)及白細(xì)胞淋巴瘤/白血病xL(Bcl-xL)的表達(dá)。結(jié)果治療組臨床療效總有效率為85.29%,對(duì)照組為58.82%,治療組明顯高于對(duì)照組(P0.05)。兩組患者治療后中醫(yī)癥狀評(píng)分、胃黏膜組織病理評(píng)分均較本組治療前明顯下降,且治療組均明顯低于對(duì)照組(P0.05或P0.01)。治療后治療組胃黏膜組織中TRAF1、4-1BB、Bcl-xL表達(dá)明顯下降,對(duì)照組TRAF1表達(dá)明顯下降,且治療組TRAF1、4-1BB、Bcl-xL表達(dá)均明顯低于對(duì)照組(P0.05或P0.01)。結(jié)論丹芪祛瘀止痛顆�？擅黠@改善氣虛血瘀型胃癌前病變患者胃黏膜組織病理情況,其機(jī)制可能與下調(diào)胃黏膜組織中TRAF1、4-1BB、Bcl-xL表達(dá)水平有關(guān)。
[Abstract]:Objective to observe the clinical effect and possible mechanism of Danqi Quyu Zhitong granule in the treatment of precancerous lesions of gastric cancer with qi deficiency and blood stasis. Methods Sixty-eight patients with precancerous lesions of gastric cancer with qi deficiency and blood stasis were randomly divided into treatment group (n = 34) and control group (n = 34). The treatment group was given Danqi Quyu Zhitong granule, 10 g each time, 3 times a day. The control group was given viritin tablets 0.8 g each time, 3 times a day. The course of treatment in both groups was 3 months. The clinical efficacy was evaluated after treatment. The symptoms of traditional Chinese medicine (TCM) and the pathology of gastric mucosa were evaluated before and after treatment. The expression of tumor necrosis factor receptor related factor 1 (TRAF1), lymphocyte activation induced receptor (4-1BB) and leukocytic lymphoma / leukemia xL (Bcl-xL) in gastric mucosa were detected. Results the total effective rate was 85.29% in the treatment group and 58.82% in the control group, which was significantly higher in the treatment group than in the control group (P 0.05). After treatment, the scores of TCM symptoms and gastric mucosa pathology in the two groups were significantly lower than those before treatment, and the scores in the treatment group were significantly lower than those in the control group (P 0.05 or P 0.01). After treatment, the expression of TRAF1,4-1BB,Bcl-xL in gastric mucosa of the treatment group was significantly decreased, the expression of TRAF1 in the control group was significantly decreased, and the expression of TRAF1,4-1BB,Bcl-xL in the treatment group was significantly lower than that in the control group (P 0.05 or P 0.01). Conclusion Danqi Quyu Zhitong granule can obviously improve the pathological situation of gastric mucosa in patients with gastric precancerous lesion of qi deficiency and blood stasis type, and its mechanism may be related to the down-regulation of TRAF1,4-1BB,Bcl-xL expression in gastric mucosa.
【作者單位】： 黑龍江省中醫(yī)藥科學(xué)院南崗分院;
【基金】：國(guó)家中醫(yī)藥管理局中醫(yī)藥科學(xué)技術(shù)研究專項(xiàng)(2016ZX05) 黑龍江省科技計(jì)劃(GC12C110) 黑龍江省博士后科研啟動(dòng)基金(LBH-Q13156)
【分類號(hào)】：R259
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本文編號(hào)：2508514