發(fā)布時間：2019-06-28 11:17

【摘要】：目的:通過觀察導(dǎo)師單兆偉教授在疏肝和胃護膜法基礎(chǔ)上創(chuàng)制的柴芍護膜湯加減治療肝胃不和型膽汁反流性胃炎(bile reflux gastritis,BRG)的臨床療效,為臨床治療BRG提供新的思路與方法。方法:①理論研究:分為現(xiàn)代醫(yī)學(xué)對BRG病因及發(fā)病機制、診斷、治療等的研究和祖國醫(yī)學(xué)對BRG的病名、病因病機、辨證分型與治療原則、治療等的研究;②臨床研究:制定肝胃不和型BRG的納入標(biāo)準,將符合條件的60例患者隨機分為試驗組和對照組,試驗組(30例)給予柴芍護膜湯加減,對照組(30例)給予枸櫞酸莫沙必利分散片和鋁碳酸鎂片,兩組均口服治療8周,利用SPSS16.0對患者臨床資料、癥狀評分,胃鏡下膽汁反流程度進行統(tǒng)計分析。結(jié)果:治療前,兩組進行性別、年齡、癥狀分布、膽汁反流程度分級比較,均無統(tǒng)計學(xué)差異(P均0.05),表明兩組具有可比性,且兩組均沒有出現(xiàn)不良反應(yīng)。兩組患者治療后癥狀均有不同程度的改善;對主要癥狀(脘脅脹痛或脹滿、噯氣吞酸、呃逆、惡心嘔吐、胃中嘈雜)的改善,兩組療效相當(dāng);對次要癥狀(不欲食、便溏、情緒抑郁或煩躁易怒、口干口苦)的改善方面療效存在差異(P0.05),試驗組優(yōu)于對照組。試驗組和對照組總有效率分別為86.7%和63.3%。兩組療效相比,試驗組中醫(yī)證候療效優(yōu)于對照組。結(jié)論:導(dǎo)師經(jīng)驗方柴芍護膜湯對治療肝胃不和型BRG具有良好的臨床療效,對患者整體癥狀的改善有著明顯優(yōu)勢,能更好地提高病人的整體生活質(zhì)量,具有較好的臨床應(yīng)用前景。
[Abstract]:Objective: to observe the clinical effect of Chaishao protective membrane decoction, which was created by professor Shan Zhaowei, on the basis of soothing liver and stomach protective membrane, in the treatment of hepatogastric bile reflux gastritis (bile reflux gastritis,BRG), and to provide a new idea and method for clinical treatment of BRG. Methods: 1 theoretical research: it is divided into the study of etiology and pathogenesis, diagnosis and treatment of BRG in modern medicine and the study of disease name, etiology and pathogenesis, syndrome differentiation, treatment principle and treatment of BRG in traditional Chinese medicine. 2 Clinical study: 60 patients with hepatogastric disharmony type BRG were randomly divided into experimental group (n = 30) and control group (n = 30). The experimental group (n = 30) was treated with mosapride citrate dispersible tablet and magnesium aluminum carbonate tablet for 8 weeks. The clinical data, symptom score and bile reflux degree under gastroscopy were statistically analyzed by SPSS16.0. Results: before treatment, there was no significant difference in sex, age, symptom distribution and bile reflux degree between the two groups (P 0.05), indicating that the two groups were comparable, and there were no adverse reactions between the two groups. After treatment, the symptoms of the two groups were improved to varying degrees, and the improvement of the main symptoms (epigastric distension, pain or fullness, belching and acid ingestion, hiccup, nausea and vomiting, stomach noise) was the same between the two groups; there were differences in the improvement of secondary symptoms (lack of food, loose stools, depression or irritability, bitter mouth and mouth) between the two groups (P 0.05), and the experimental group was superior to the control group in improving the secondary symptoms (lack of food, loose stools, depression or irritability, bitter mouth, dry mouth and mouth). The total effective rates of the experimental group and the control group were 86.7% and 63.3%, respectively. Compared with the two groups, the curative effect of TCM syndrome in the experimental group was better than that in the control group. Conclusion: Fangchai Shaohumembrane decoction has a good clinical effect on the treatment of liver-stomach disharmony BRG, has obvious advantages in improving the overall symptoms of the patients, can improve the overall quality of life of the patients, and has a good clinical application prospect.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R259

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