喉源性咳嗽發(fā)病影響因素的初步調(diào)查研究
發(fā)布時(shí)間：2019-03-19 09:19
【摘要】：目的:對(duì)喉源性咳嗽的患者進(jìn)行發(fā)病影響因素的初步調(diào)查研究,為今后喉源性咳嗽流行病學(xué)大樣本研究及臨床更好地防治喉源性咳嗽提供參考依據(jù)。方法:選擇符合喉源性咳嗽診斷標(biāo)準(zhǔn)的患者200例作實(shí)驗(yàn)組,正常人100例作對(duì)照組,通過病史、臨床癥狀體征的數(shù)據(jù)采集、外周血常規(guī)、纖維鼻咽喉鏡檢查、胸部X線片檢查、C-反應(yīng)蛋白及吸入性變應(yīng)原篩查等指標(biāo)的檢測,填寫調(diào)查問卷表,建立數(shù)據(jù)庫,懫用SPSS19.0統(tǒng)計(jì)軟件進(jìn)行所有資料的統(tǒng)計(jì)學(xué)分析,得出結(jié)論。結(jié)果:1.在200例實(shí)驗(yàn)組中,男性92例(46%),女性108例(54%)。年齡40歲患者104例(52%),年齡≥40歲患者96例(48%),嗜煙酒者32例(16%),因受涼誘發(fā)者132例(66%),因感冒誘發(fā)者86例(43%),因過度勞累誘發(fā)者95例(47.5%),因食辛辣刺激食物導(dǎo)致者82例(41%),塵螨過敏所致者116例(58%)。在100例對(duì)照組中,男性56例(56%),女性44例(44%)。年齡40歲者54例(54%),年齡≥40歲者46例(46%),嗜煙酒者13例(13%),近一個(gè)月有受涼病史者8例(8%),有感冒病史者10例(10%),有過度勞累者12例(12%),喜食辛辣刺激食物者13例(13%),塵螨過敏者14例(14%)。通過采用二分類非條件Logistic回歸進(jìn)行單因素分析,結(jié)果顯示:受涼、感冒、過度勞累、喜食刺激辛辣食物、塵螨過敏經(jīng)比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),說明受涼、感冒、過度勞累、喜食辛辣刺激食物、塵螨過敏可能是喉源性咳嗽患病的影響因素。然后將受涼、感冒、過度勞累、喜食辛辣刺激食物、塵螨過敏等可能影響因素進(jìn)行二分類非條件Logistic回歸多因素分析,結(jié)果同樣顯示:受涼、感冒、過度勞累、喜食辛辣刺激食物、塵螨過敏與喉源性咳嗽的發(fā)病有相關(guān)性,且從回歸系數(shù)上看,與喉源性咳嗽的發(fā)病均呈正相關(guān)。2.在喉源性咳嗽發(fā)病影響因素的初步調(diào)查研究過程中,隨機(jī)選擇88名患者進(jìn)行血清肺炎支原體抗體檢測,結(jié)果無意中發(fā)現(xiàn)有41名患者呈陽性反應(yīng),陽性率達(dá)46.59%。隨后在正常人中隨機(jī)選擇25人作對(duì)照組進(jìn)行血清肺炎支原體抗體檢測,檢出率為8%。且經(jīng)統(tǒng)計(jì)學(xué)分析,結(jié)果顯示:肺炎支原體因素經(jīng)比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),證實(shí)了喉源性咳嗽的發(fā)病與肺炎支原體感染有一定的相關(guān)性。結(jié)論:在此次喉源性咳嗽發(fā)病影響因素的初步調(diào)查研究中發(fā)現(xiàn)受涼、感冒、過度勞累、喜食辛辣刺激食物、塵螨過敏、肺炎支原體感染等因素,皆可誘發(fā)喉源性咳嗽病,差異顯著;而性別、年齡與喉源性咳嗽發(fā)病無關(guān),吸煙或飲酒等因素與喉源性咳嗽發(fā)病也無明顯相關(guān)性。因此,在臨床衛(wèi)生宣教工作中須鼓勵(lì)大家盡可能避開影響因素,降低喉源性咳嗽之發(fā)病率及縮短喉源性咳嗽之療程。
[Abstract]:Aim: to investigate the influential factors of laryngeal cough in patients with laryngogenic cough, and to provide reference basis for future epidemiological large samples of laryngeal cough and clinical prevention and treatment of laryngogenic cough. Methods: 200 patients who met the diagnostic criteria of laryngogenic cough were selected as experimental group and 100 normal persons as control group. The data collection of clinical symptoms and signs, peripheral blood routine examination, fibernasopharyngoscope and chest X-ray examination were carried out through medical history, clinical symptoms and signs, routine examination of peripheral blood. C-reactive protein and inhalant allergen screening were tested, questionnaire forms were filled out, database was established, and all data were analyzed by SPSS19.0 statistical software, and conclusions were drawn. Results: 1. Of the 200 cases, 92 (46%) were male and 108 (54%) were female. 104 cases (52%) were 40 years old, 96 cases (48%) were over 40 years old, 32 cases (16%) were smoking and drinking, 132 cases (66%) were induced by cold, 86 cases (43%) were caused by cold. 95 cases (47.5%) were induced by overwork, 82 cases (41%) were caused by spicy food, 116 cases (58%) were caused by dust mite allergy. In 100 cases of control group, 56 cases (56%) were male and 44 cases (44%) were female. 54 cases (54%) were 40 years old, 46 cases (46%) were over 40 years old, 13 cases (13%) were smoking and drinking, 8 cases (8%) had history of cold in the last month, 10 cases (10%) had history of cold. There were 12 cases (12%) with overwork, 13 cases (13%) with acrid food stimulation and 14 cases (14%) with allergies to dust mites. Single factor analysis was carried out by using two classification non-conditional Logistic regression. The results showed that cold, overwork, preference to eat stimulating spicy food, dust mite allergy were statistically significant (P0.05), indicating that cold, cold. Overwork, love to eat spicy food, dust mite allergy may be a risk factor for laryngogenic cough. Then the factors such as cold, overwork, food stimulation, dust mite allergy and so on were analyzed by Logistic regression. The results also showed that cold, overwork, and so on, could affect the factors of cold, overwork, and so on, and the results were as follows: cold, overwork, and so on. There was a positive correlation between allergies of dust mites and laryngogenic cough, and the regression coefficient showed that there was a positive correlation between allergies of dust mites and laryngogenic cough. 2. In the course of preliminary investigation on the influencing factors of laryngeal cough, 88 patients were randomly selected for detection of mycoplasma pneumoniae antibody in serum. The results showed that 41 patients showed positive reaction, the positive rate was 46.59%. Then 25 healthy subjects were randomly selected as control group for detection of mycoplasma pneumoniae antibody, the detection rate was 8%. By statistical analysis, the results showed that the mycoplasma pneumoniae factors were significantly different (P0.05), which confirmed that the incidence of laryngogenic cough and Mycoplasma pneumoniae infection had a certain correlation. Conclusion: in the preliminary investigation of the influencing factors of laryngeal cough, it was found that cold, overwork, food stimulation, dust mite allergy, mycoplasma pneumoniae infection and other factors could induce laryngogenic cough, and that the disease was caused by cold, overwork, acrid food, dust mite allergy, mycoplasma pneumoniae infection, and so on. The difference was significant. There was no significant correlation between sex, age and laryngogenic cough. Smoking or drinking had no significant correlation with laryngogenic cough. Therefore, people should be encouraged to avoid the influence factors, reduce the incidence of laryngogenic cough and shorten the course of treatment of laryngogenic cough.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R276.1
[Abstract]:Aim: to investigate the influential factors of laryngeal cough in patients with laryngogenic cough, and to provide reference basis for future epidemiological large samples of laryngeal cough and clinical prevention and treatment of laryngogenic cough. Methods: 200 patients who met the diagnostic criteria of laryngogenic cough were selected as experimental group and 100 normal persons as control group. The data collection of clinical symptoms and signs, peripheral blood routine examination, fibernasopharyngoscope and chest X-ray examination were carried out through medical history, clinical symptoms and signs, routine examination of peripheral blood. C-reactive protein and inhalant allergen screening were tested, questionnaire forms were filled out, database was established, and all data were analyzed by SPSS19.0 statistical software, and conclusions were drawn. Results: 1. Of the 200 cases, 92 (46%) were male and 108 (54%) were female. 104 cases (52%) were 40 years old, 96 cases (48%) were over 40 years old, 32 cases (16%) were smoking and drinking, 132 cases (66%) were induced by cold, 86 cases (43%) were caused by cold. 95 cases (47.5%) were induced by overwork, 82 cases (41%) were caused by spicy food, 116 cases (58%) were caused by dust mite allergy. In 100 cases of control group, 56 cases (56%) were male and 44 cases (44%) were female. 54 cases (54%) were 40 years old, 46 cases (46%) were over 40 years old, 13 cases (13%) were smoking and drinking, 8 cases (8%) had history of cold in the last month, 10 cases (10%) had history of cold. There were 12 cases (12%) with overwork, 13 cases (13%) with acrid food stimulation and 14 cases (14%) with allergies to dust mites. Single factor analysis was carried out by using two classification non-conditional Logistic regression. The results showed that cold, overwork, preference to eat stimulating spicy food, dust mite allergy were statistically significant (P0.05), indicating that cold, cold. Overwork, love to eat spicy food, dust mite allergy may be a risk factor for laryngogenic cough. Then the factors such as cold, overwork, food stimulation, dust mite allergy and so on were analyzed by Logistic regression. The results also showed that cold, overwork, and so on, could affect the factors of cold, overwork, and so on, and the results were as follows: cold, overwork, and so on. There was a positive correlation between allergies of dust mites and laryngogenic cough, and the regression coefficient showed that there was a positive correlation between allergies of dust mites and laryngogenic cough. 2. In the course of preliminary investigation on the influencing factors of laryngeal cough, 88 patients were randomly selected for detection of mycoplasma pneumoniae antibody in serum. The results showed that 41 patients showed positive reaction, the positive rate was 46.59%. Then 25 healthy subjects were randomly selected as control group for detection of mycoplasma pneumoniae antibody, the detection rate was 8%. By statistical analysis, the results showed that the mycoplasma pneumoniae factors were significantly different (P0.05), which confirmed that the incidence of laryngogenic cough and Mycoplasma pneumoniae infection had a certain correlation. Conclusion: in the preliminary investigation of the influencing factors of laryngeal cough, it was found that cold, overwork, food stimulation, dust mite allergy, mycoplasma pneumoniae infection and other factors could induce laryngogenic cough, and that the disease was caused by cold, overwork, acrid food, dust mite allergy, mycoplasma pneumoniae infection, and so on. The difference was significant. There was no significant correlation between sex, age and laryngogenic cough. Smoking or drinking had no significant correlation with laryngogenic cough. Therefore, people should be encouraged to avoid the influence factors, reduce the incidence of laryngogenic cough and shorten the course of treatment of laryngogenic cough.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R276.1
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