棄杖膠囊治療腎虛血瘀型股骨頭缺血性壞死的臨床觀察
發(fā)布時間：2019-03-18 20:00
【摘要】：目的通過對棄杖膠囊治療腎虛血瘀型股骨頭缺血性壞死的患者進行臨床相關(guān)研究,證明棄杖膠囊對腎虛血瘀型股骨頭缺血性壞死患者臨床上治療有效。方法根據(jù)該課題的相關(guān)納入標準,收集篩選在2014年6月-2015年12月期間就診于黑龍江省中醫(yī)醫(yī)院骨傷科,由骨傷科中醫(yī)專家滕義和教授門診接診的股骨頭缺血性壞死的患者,初診患者總計160例,其中106例符合,按照隨機數(shù)字表和患者先后就診時間分為治療組和對照組,每組53例包含著(ARCO I期、II期、IIIA期),中醫(yī)辨證是腎虛血瘀型,其中治療組患者服用棄杖膠囊,對照組患者服用仙靈骨葆膠囊,年齡選取在35-55歲,男女均可入組,使其除在分組不同外,其余均無顯著性差異(包括性別,年齡,體重,基礎(chǔ)疾病等方面)。觀察兩組用藥3個月之后,記錄治療組和對照組的患者疼痛VAS評分和Harris髖關(guān)節(jié)功能評分以及MRI壞死指數(shù)三個指標相關(guān)數(shù)據(jù)。根據(jù)兩組數(shù)據(jù)進行統(tǒng)計學(xué)分析P0.05,評價棄杖膠囊對腎虛血瘀型股骨頭缺血性壞死的療效,進而總結(jié)對比分析來揭露補腎祛瘀接骨法對治療股骨頭缺血性壞死疾病存在的機理。對入組的兩組患者疼痛VAS評分和Harris髖關(guān)節(jié)功能評分以及MRI壞死指數(shù)進行收集記錄,再建立數(shù)據(jù)庫,應(yīng)用SPSS17.0forwindows統(tǒng)計軟件,計量資料采用均數(shù)±標準差(x±s)表示,多組數(shù)據(jù)使用單因素方差分析方法(F檢驗)。結(jié)果治療結(jié)束后,兩組患者疼痛VAS評分、Harris髖關(guān)節(jié)功能評分、MRI壞死指數(shù)與治療前進行組內(nèi)比較,三項指標均有統(tǒng)計學(xué)意義(P0.05)。治療后的組間比較,疼痛VAS評分、MRI壞死指數(shù)具有統(tǒng)計學(xué)意義(P0.05),而Harris髖關(guān)節(jié)功能評分沒有統(tǒng)計學(xué)意義(P0.05),提示治療組改善疼痛和減少壞死體積優(yōu)于對照組,而在改善Harris髖關(guān)節(jié)功能兩組差異不顯著,兩組在治療前后股骨頭壞死的分期上沒有顯著性差異(即P0.05),提示兩組對患者影像學(xué)分期沒有明顯治療意義。治療組顯效9例、有效30例、無效11例,有效率78%;而對照組顯效7例、有效27例、無效16例,有效率68%,提示治療組有效率高于對照組。結(jié)論1.棄杖膠囊對腎虛血瘀型股骨頭缺血性壞死臨床治療改善疼痛評分有效。2.棄杖膠囊在改善腎虛血瘀型股骨頭缺血性壞死Harris髖關(guān)節(jié)功能評分有效。3.棄杖膠囊治療前后影像學(xué)分期上沒有明顯效果,而僅僅在減少壞死體積上有治療意義。
[Abstract]:Aim to study the clinical effect of Juzhu capsule on avascular necrosis of femoral head of kidney deficiency and blood stasis type, and to prove that it is effective in treating avascular necrosis of femoral head of kidney deficiency and blood stasis type. Methods according to the inclusion criteria of the subject, the patients with avascular necrosis of the femoral head who were treated in the Department of Orthopaedics of Heilongjiang Province traditional Chinese Medicine Hospital from June 2014 to December 2015 were collected and selected. The patients were divided into treatment group and control group according to the random number table and the time of visit, 53 cases in each group included (ARCO I stage, II stage, IIIA stage). The syndrome differentiation of TCM was kidney deficiency and blood stasis type, and the syndrome differentiation of TCM was kidney deficiency and blood stasis type, and the patients were divided into treatment group and control group according to the random number table. The patients in the treatment group and the control group took Xianling Gubao capsule. The age was 35 years old and 55 years old. Both men and women could be admitted into the group, so that there was no significant difference (including sex, age, weight, etc.), except in the different groups, the other groups had no significant difference (including sex, age, body weight). Basic diseases, etc.) The pain VAS score, Harris hip function score and MRI necrosis index were recorded in the treatment group and the control group 3 months after the treatment of the treatment group and the control group. 3 months later, the pain score, the hip joint function score and the MRI necrosis index were recorded. According to the data of the two groups, a statistical analysis of P0.05 was carried out to evaluate the curative effect of abandoned stick capsule on avascular necrosis of the femoral head of kidney deficiency and blood stasis type. The mechanism of the treatment of avascular necrosis of femoral head by tonifying the kidney and removing blood stasis and connecting bone was revealed. The pain VAS score, Harris hip function score and MRI necrosis index were collected and recorded in the two groups. Then a database was established. The data were expressed by mean 鹵standard deviation (xtable s) using SPSS17.0forwindows statistical software. One-way variance analysis (F-test) was used for multiple sets of data. Results after treatment, the pain VAS score, Harris hip function score and MRI necrosis index were significantly different between the two groups before and after treatment (P0.05). After treatment, the pain VAS score and MRI necrosis index had statistical significance (P0.05), but the Harris hip function score had no statistical significance (P0.05), suggesting that the treatment group was better than the control group in improving pain and reducing necrosis volume. However, there was no significant difference between the two groups in improving the hip function of Harris, and there was no significant difference in the stage of femoral head necrosis before and after treatment between the two groups (P0.05), suggesting that the two groups had no significant therapeutic significance in the imaging stage of the patients. In the treatment group, 9 cases were effective, 30 cases were effective, 11 cases were ineffective, and the effective rate was 78%, while that in the control group was 7 cases, 27 cases and 16 cases, and the effective rate was 68%, which indicated that the effective rate in the treatment group was higher than that in the control group. Conclusion 1. The clinical treatment of avascular necrosis of femoral head with kidney deficiency and blood stasis type is effective in improving pain score. 2. It is effective in improving Harris hip function score of avascular necrosis of femoral head with kidney deficiency and blood stasis type. 3. It has no obvious effect on imaging stages before and after treatment, but only has therapeutic significance in reducing necrotic volume.
【學(xué)位授予單位】：黑龍江省中醫(yī)藥科學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R274.9
，
本文編號：2443186
[Abstract]:Aim to study the clinical effect of Juzhu capsule on avascular necrosis of femoral head of kidney deficiency and blood stasis type, and to prove that it is effective in treating avascular necrosis of femoral head of kidney deficiency and blood stasis type. Methods according to the inclusion criteria of the subject, the patients with avascular necrosis of the femoral head who were treated in the Department of Orthopaedics of Heilongjiang Province traditional Chinese Medicine Hospital from June 2014 to December 2015 were collected and selected. The patients were divided into treatment group and control group according to the random number table and the time of visit, 53 cases in each group included (ARCO I stage, II stage, IIIA stage). The syndrome differentiation of TCM was kidney deficiency and blood stasis type, and the syndrome differentiation of TCM was kidney deficiency and blood stasis type, and the patients were divided into treatment group and control group according to the random number table. The patients in the treatment group and the control group took Xianling Gubao capsule. The age was 35 years old and 55 years old. Both men and women could be admitted into the group, so that there was no significant difference (including sex, age, weight, etc.), except in the different groups, the other groups had no significant difference (including sex, age, body weight). Basic diseases, etc.) The pain VAS score, Harris hip function score and MRI necrosis index were recorded in the treatment group and the control group 3 months after the treatment of the treatment group and the control group. 3 months later, the pain score, the hip joint function score and the MRI necrosis index were recorded. According to the data of the two groups, a statistical analysis of P0.05 was carried out to evaluate the curative effect of abandoned stick capsule on avascular necrosis of the femoral head of kidney deficiency and blood stasis type. The mechanism of the treatment of avascular necrosis of femoral head by tonifying the kidney and removing blood stasis and connecting bone was revealed. The pain VAS score, Harris hip function score and MRI necrosis index were collected and recorded in the two groups. Then a database was established. The data were expressed by mean 鹵standard deviation (xtable s) using SPSS17.0forwindows statistical software. One-way variance analysis (F-test) was used for multiple sets of data. Results after treatment, the pain VAS score, Harris hip function score and MRI necrosis index were significantly different between the two groups before and after treatment (P0.05). After treatment, the pain VAS score and MRI necrosis index had statistical significance (P0.05), but the Harris hip function score had no statistical significance (P0.05), suggesting that the treatment group was better than the control group in improving pain and reducing necrosis volume. However, there was no significant difference between the two groups in improving the hip function of Harris, and there was no significant difference in the stage of femoral head necrosis before and after treatment between the two groups (P0.05), suggesting that the two groups had no significant therapeutic significance in the imaging stage of the patients. In the treatment group, 9 cases were effective, 30 cases were effective, 11 cases were ineffective, and the effective rate was 78%, while that in the control group was 7 cases, 27 cases and 16 cases, and the effective rate was 68%, which indicated that the effective rate in the treatment group was higher than that in the control group. Conclusion 1. The clinical treatment of avascular necrosis of femoral head with kidney deficiency and blood stasis type is effective in improving pain score. 2. It is effective in improving Harris hip function score of avascular necrosis of femoral head with kidney deficiency and blood stasis type. 3. It has no obvious effect on imaging stages before and after treatment, but only has therapeutic significance in reducing necrotic volume.
【學(xué)位授予單位】：黑龍江省中醫(yī)藥科學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R274.9
，
本文編號：2443186
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