【摘要】：目的:研究非緩解期Graves病患者與正常人的中醫(yī)體質(zhì)分布規(guī)律,以期在未出現(xiàn)Graves病時(shí),發(fā)現(xiàn)Graves病的高危體質(zhì),調(diào)整失衡的體質(zhì),以避免或者減少Graves病和相關(guān)并發(fā)癥的發(fā)生。方法:甲亢組納入非緩解期Graves病患者共300例,正常組納入正常人102例,分別填寫甲亢體質(zhì)調(diào)查表及正常人體質(zhì)調(diào)查表,通過體質(zhì)調(diào)查表來判定的體質(zhì)類型,并且記錄受試者的一般情況、患病情況、甲狀腺功能。研究非緩解期Graves病患者、正常人體質(zhì)分布規(guī)律,以及體質(zhì)與患者甲狀腺腫大程度、突眼、粒細(xì)胞減少、甲亢肝損害、甲狀腺激素、甲狀腺相關(guān)抗體之間是否有相關(guān)關(guān)系。結(jié)果:1.正常人組,平和質(zhì)出現(xiàn)頻次最多(43.6%);氣虛質(zhì)其次(13.9%);甲亢組,氣虛質(zhì)出現(xiàn)頻次最多(23.8%);陰虛質(zhì)其次(17.6%);平和質(zhì)(13.2%);氣郁質(zhì)(12.1%),兩組的體質(zhì)類型分布具有顯著性差異(χ2=96.38,P0.001)。2.甲亢患者中,單一體質(zhì)106例(35.3%),復(fù)合體質(zhì)194例(64.7%),以復(fù)合體質(zhì)為主。甲亢發(fā)病率女性高于男性,男:女為1:2.48,年齡分布在21~30歲之間的最多,高發(fā)年齡為20~50歲。3.正常人組與甲亢初發(fā)組、治療后病程2年組、治療后病程≥2年組體質(zhì)頻次之間的差異均有統(tǒng)計(jì)學(xué)意義(p0.001);體質(zhì)甲亢初發(fā)組、治療后病程2年組、治療后病程≥2年組三者體質(zhì)頻次之間的差異無統(tǒng)計(jì)學(xué)意義(p0.05)。4.突眼組和無突眼組體質(zhì)頻次之間的差異有顯著的統(tǒng)計(jì)學(xué)意義(p0.01),甲狀腺腫大Ⅱ度組和≥Ⅱ度組、粒細(xì)胞減少組和無粒細(xì)胞減少組、肝損害組和無肝損害組體質(zhì)頻次之間的差異無統(tǒng)計(jì)學(xué)意義(p0.05),TGAb、TRAb、TMAb各分段組的體質(zhì)頻次之間的差異無統(tǒng)計(jì)學(xué)意義(p0.05)。5.向前逐步法logistic回歸分析:年齡與氣虛質(zhì)成正相關(guān)(P0.05,OR值為1.023;95%C.I:1.003-1.004),突眼與陰虛質(zhì)成正相關(guān)(P0.05,OR值為2.068;95%C.I:1.114-3.838),甲狀腺腫大與氣郁質(zhì)成正相關(guān)(P0.05,OR值為1.843;95%C.I:1.015-3.349)。結(jié)論:1.正常組,平和質(zhì)最多、氣虛質(zhì)次之;甲亢組主要體質(zhì)為氣虛質(zhì)、陰虛質(zhì)、氣郁質(zhì)、平和質(zhì),以兼夾體質(zhì)為主,兩組的體質(zhì)分布不同。2.非緩解期Graves病發(fā)病率女性高于男性,年齡分布在21~30歲之間的最多,高發(fā)年齡為20~50歲。3.年齡與氣虛質(zhì)成正相關(guān),突眼與陰虛質(zhì)成正相關(guān),甲狀腺腫大與氣郁質(zhì)成正相關(guān)。
[Abstract]:Objective: to study the distribution of TCM physique in patients with non-remission Graves's disease and normal people in order to find the high risk constitution of Graves disease and adjust the unbalanced constitution in order to avoid or reduce the occurrence of Graves disease and related complications. Methods: a total of 300 patients with non-remission Graves's disease were included in the hyperthyroidism group and 102 normal persons were included in the normal group. The general condition, illness and thyroid function of the subjects were recorded. To study the distribution of constitution in patients with non-remission Graves's disease and the relationship between constitution and goitre degree, exophthalmos, granulocytosis, hyperthyroidism liver damage, thyroid hormone and thyroid-associated antibody. Results: 1. In the normal group, the frequency of calmness (43.6%), deficiency of qi (13.9%), hyperthyroidism (23.8%), deficiency of yin (17.6%), calmness (13.2%) were the most frequent. There was a significant difference in the distribution of physical types between the two groups (蠂 ~ (2) P ~ (96.38) P _ (0.001). Among the patients with hyperthyroidism, 106 (35.3%) had a single constitution and 194 (64.7%) had a compound constitution. The incidence of hyperthyroidism in women was higher than that in men (1: 2.48 for men). The most common age was between 21 and 30 years old, and the high incidence rate was 20 to 50 years old. There were significant differences in physical fitness frequency between the normal group and the hyperthyroidism group, the course of disease 2 years after treatment and the course 鈮，

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