紅花注射液關節(jié)腔沖洗結合鉤針治療膝骨性關節(jié)炎的臨床療效觀察
發(fā)布時間：2019-01-03 06:23
【摘要】：目的通過采用紅花注射液關節(jié)腔沖洗結合鉤針治療膝關節(jié)骨性關節(jié)炎,依據(jù)Lysholm膝關節(jié)評分、膝關節(jié)HSS評分法評價其臨床療效,總結分析紅花注射液關節(jié)腔沖洗結合鉤針治療膝關節(jié)骨性關節(jié)炎的臨床療效。方法采用臨床隨機對照法進行研究,選擇2014年11月至2015年5月就診于山西省中西醫(yī)結合醫(yī)院疼痛科且符合納入標準的膝關節(jié)骨性關節(jié)炎住院患者,臨床收集90例,年齡50—80歲,并依據(jù)患者就診順序按Doll’s隨機數(shù)字表法分為生理鹽水沖洗組(A組)、紅花注射液關節(jié)腔沖洗組(B組)、紅花注射液關節(jié)腔沖洗結合鉤針治療組(C組),A組為對照組,B組和C組為試驗組,每組各30例。治療前依據(jù)Lysholm膝關節(jié)評分、膝關節(jié)HSS評分法進行治療前評分,完善相關輔助檢查后對符合納入標準的患者分別采用上述三種方法進行治療,各治療兩次。患者治療結束后一周及出院1月后隨訪,依據(jù)Lysholm膝關節(jié)評分、膝關節(jié)HSS評分法進行評分。臨床研究的數(shù)據(jù)資料采用SPSS 17.0統(tǒng)計軟件分析,對所獲數(shù)據(jù)采用完全隨機的多組樣本均數(shù)比較,使用單因素方差分析法(ANOVA),數(shù)據(jù)以x±S表示,以P0.05為有差異性,具有統(tǒng)計學意義。若數(shù)據(jù)呈正態(tài)分布,方差齊,且各組數(shù)值之間有統(tǒng)計學意義,用LSD檢驗進行多重比較分析;若方差不齊,在有統(tǒng)計學意義的基礎上,采用Tamhane’s T2檢驗進行多重比較。結果(1)三組在患者年齡、性別、病程、單雙膝關節(jié)數(shù)量方面比較,經(jīng)方差分析檢驗,P0.05,差異無統(tǒng)計學意義;(2)三組患者治療前Lysholm膝關節(jié)評分、膝關節(jié)HSS評分比較,經(jīng)方差分析檢驗,P0.05,差異無統(tǒng)計學意義;(3)三組患者治療前病情嚴重程度比較,經(jīng)方差分析檢驗,P0.05,差異無統(tǒng)計學意義;(4)治療后1周及治療后1月與治療前對比,依據(jù)Lysholm膝關節(jié)評分、膝關節(jié)HSS評分法比較,經(jīng)方差分析檢驗,三組P值均0.05,差異有統(tǒng)計學意義;(5)治療后1周三組之間進行療效對比,A組與B組相比,經(jīng)方差分析檢驗,P0.05,差異無統(tǒng)計學意義,A組與C組相比,P0.05,差異有統(tǒng)計學意義,B組與C組相比,P0.05,差異有統(tǒng)計學意義;(6)治療后1月三組之間進行療效對比,經(jīng)方差分析檢驗,依據(jù)Lysholm膝關節(jié)評分,A組與B組相比,P0.05,差異無統(tǒng)計學意義,A組與C組相比,P0.05,差異有統(tǒng)計學意義,B組與C組相比,P0.05,差異有統(tǒng)計學意義;而依據(jù)膝關節(jié)HSS評分,三組之間對比,P值均0.05,差異有統(tǒng)計學意義;(7)治療后1周及治療后1月三組之間總體療效對比,經(jīng)方差分析檢驗,P0.05,差異具有統(tǒng)計學意義,可以認為三組療效有差異,而C組總體療效均優(yōu)于A組和B組。結論紅花注射液關節(jié)腔沖洗結合鉤針治療膝骨性關節(jié)炎較單純采用關節(jié)腔沖洗相比,取得較好臨床療效,是治療KOA安全有效、療效確切的方法。
[Abstract]:Objective to evaluate the clinical efficacy of safflower injection combined with crochet needle in the treatment of knee osteoarthritis according to Lysholm knee score and knee joint HSS score. To summarize and analyze the clinical effect of safflower injection combined with crochet needle in the treatment of knee osteoarthritis. Methods from November 2014 to May 2015, 90 patients with knee osteoarthritis, who were admitted to the pain Department of Shanxi Integrated Chinese and Western Medicine Hospital and met the inclusion criteria, were selected from a randomized controlled clinical study. The patients aged 50-80 years were randomly divided into two groups: saline irrigation group (group A) and safflower injection joint cavity irrigation group (group B) according to the Doll's sequence. Safflower injection combined with crochet needle treatment group (group C), A as control group, B group and C group as experimental group, 30 cases in each group). According to the Lysholm knee joint score and the knee joint HSS score before treatment, the patients who met the inclusion criteria were treated with the above three methods respectively, two times each after the improvement of relevant auxiliary examination. The patients were followed up one week after treatment and one month after discharge. According to Lysholm knee score and knee joint HSS score. The data of clinical study were analyzed by SPSS 17.0 statistical software. The data were compared with each other by random multi-group sample mean. The (ANOVA), data of single factor variance analysis was expressed as x 鹵S, and the difference was P0.05. It has statistical significance. If the data is normal distribution, the variance is homogeneous, and there is statistical significance among the values of each group, the LSD test is used to carry out multiple comparative analysis; if the variance is not uniform, on the basis of statistical significance, the Tamhane's T2 test is used to carry out multiple comparisons. Results (1) there was no significant difference among the three groups in age, sex, course of disease and the number of single and double knee joints. The variance analysis showed that there was no significant difference between the three groups in age, sex, course of disease and the number of single and double knee joints. (2) there was no significant difference in Lysholm knee joint score and knee joint HSS score between the three groups before treatment (P 0.05). (3) there was no significant difference in the severity of the disease between the three groups before treatment (P 0.05). (4) 1 week after treatment and 1 month after treatment compared with before treatment, according to Lysholm knee joint score, knee joint HSS score comparison, by variance analysis test, the three groups P value were 0.05, the difference was statistically significant; (5) there was no significant difference between group A and group B by ANOVA test (P0.05), the difference between group A and group C (P0.05) was statistically significant, the difference between group A and group C was statistically significant, and the difference between group B and group C was statistically significant. P0.05, the difference was statistically significant. (6) after 1 month of treatment, the curative effect was compared among the three groups. According to the Lysholm knee joint score, there was no significant difference between group A and group B (P0.05, P 0.05, P 0.05). The difference was statistically significant, compared with group C, P 0.05, the difference was statistically significant. According to the HSS score of knee joint, there were significant differences among the three groups (P = 0.05). (7) the total curative effect of group C was better than that of group A and B after 1 week of treatment and 1 month after treatment. The variance analysis showed that the difference was statistically significant (P0.05), and the total curative effect of group C was better than that of group A and B. Conclusion the safflower injection combined with crochet needle in the treatment of knee osteoarthritis has a better clinical effect than that of simple joint cavity washing. It is a safe and effective method for the treatment of KOA.
【學位授予單位】：山西中醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R274.9
本文編號：2399004
[Abstract]:Objective to evaluate the clinical efficacy of safflower injection combined with crochet needle in the treatment of knee osteoarthritis according to Lysholm knee score and knee joint HSS score. To summarize and analyze the clinical effect of safflower injection combined with crochet needle in the treatment of knee osteoarthritis. Methods from November 2014 to May 2015, 90 patients with knee osteoarthritis, who were admitted to the pain Department of Shanxi Integrated Chinese and Western Medicine Hospital and met the inclusion criteria, were selected from a randomized controlled clinical study. The patients aged 50-80 years were randomly divided into two groups: saline irrigation group (group A) and safflower injection joint cavity irrigation group (group B) according to the Doll's sequence. Safflower injection combined with crochet needle treatment group (group C), A as control group, B group and C group as experimental group, 30 cases in each group). According to the Lysholm knee joint score and the knee joint HSS score before treatment, the patients who met the inclusion criteria were treated with the above three methods respectively, two times each after the improvement of relevant auxiliary examination. The patients were followed up one week after treatment and one month after discharge. According to Lysholm knee score and knee joint HSS score. The data of clinical study were analyzed by SPSS 17.0 statistical software. The data were compared with each other by random multi-group sample mean. The (ANOVA), data of single factor variance analysis was expressed as x 鹵S, and the difference was P0.05. It has statistical significance. If the data is normal distribution, the variance is homogeneous, and there is statistical significance among the values of each group, the LSD test is used to carry out multiple comparative analysis; if the variance is not uniform, on the basis of statistical significance, the Tamhane's T2 test is used to carry out multiple comparisons. Results (1) there was no significant difference among the three groups in age, sex, course of disease and the number of single and double knee joints. The variance analysis showed that there was no significant difference between the three groups in age, sex, course of disease and the number of single and double knee joints. (2) there was no significant difference in Lysholm knee joint score and knee joint HSS score between the three groups before treatment (P 0.05). (3) there was no significant difference in the severity of the disease between the three groups before treatment (P 0.05). (4) 1 week after treatment and 1 month after treatment compared with before treatment, according to Lysholm knee joint score, knee joint HSS score comparison, by variance analysis test, the three groups P value were 0.05, the difference was statistically significant; (5) there was no significant difference between group A and group B by ANOVA test (P0.05), the difference between group A and group C (P0.05) was statistically significant, the difference between group A and group C was statistically significant, and the difference between group B and group C was statistically significant. P0.05, the difference was statistically significant. (6) after 1 month of treatment, the curative effect was compared among the three groups. According to the Lysholm knee joint score, there was no significant difference between group A and group B (P0.05, P 0.05, P 0.05). The difference was statistically significant, compared with group C, P 0.05, the difference was statistically significant. According to the HSS score of knee joint, there were significant differences among the three groups (P = 0.05). (7) the total curative effect of group C was better than that of group A and B after 1 week of treatment and 1 month after treatment. The variance analysis showed that the difference was statistically significant (P0.05), and the total curative effect of group C was better than that of group A and B. Conclusion the safflower injection combined with crochet needle in the treatment of knee osteoarthritis has a better clinical effect than that of simple joint cavity washing. It is a safe and effective method for the treatment of KOA.
【學位授予單位】：山西中醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R274.9
【參考文獻】
相關期刊論文 前10條
1 扈曉佳;殷莎;袁婷婷;王玉玨;黃珍茹;陸陽;;紅花的化學成分及其藥理活性研究進展[J];藥學實踐雜志;2013年03期
2 鄭吉元;姜勁挺;安文博;張偉平;;中醫(yī)配合輸液式關節(jié)沖洗治療膝骨性關節(jié)炎[J];中國中醫(yī)骨傷科雜志;2013年04期
3 張歡;張立偉;;紅花黃色素抗氧化活性研究[J];化學研究與應用;2012年05期
4 秦杏坤;柳慶坤;薛會茹;李亞貞;胡英改;趙建偉;;亞硫酸鹽和雌激素及炎癥因子在老年女性膝骨關節(jié)炎血清與關節(jié)液中的水平及意義[J];河北醫(yī)藥;2012年06期
5 農澤寧;;針刀治療慢性軟組織損傷的研究進展[J];微創(chuàng)醫(yī)學;2011年05期
6 徐萬群;石磊;顧華麗;蔡尚郎;;紅花黃色素對急性冠狀動脈綜合征病人炎癥因子影響[J];青島大學醫(yī)學院學報;2011年05期
7 金鳴;裴崇強;臧寶霞;王麟;;羥基紅花黃色素A緩解血小板激活因子誘導的內皮細胞炎癥因子表達升高作用的研究[J];心肺血管病雜志;2011年05期
8 郭浩山;劉剛;安龍;徐金華;楊廣環(huán);;丹參粉針溶液脈沖沖洗治療膝骨性關節(jié)炎療效觀察[J];臨床合理用藥雜志;2011年30期
9 陳為堅;靳安民;陳奕雄;段楊;胡孔和;;關節(jié)鏡下清理與鉆孔減壓術治療膝關節(jié)骨性關節(jié)炎[J];中國矯形外科雜志;2011年03期
10 李振榮;;關節(jié)沖洗液的研究進展[J];護理研究;2011年04期
，本文編號：2399004
本文鏈接：http://sikaile.net/zhongyixuelunwen/2399004.html
最近更新
教材專著
