【摘要】：目的:觀察速效降脂舒肝湯治療非酒精性脂肪肝的臨床療效。方法:78例非酒精性脂肪性肝炎患者隨機(jī)分為對照組和觀察組,每組39例。對照組給予多烯磷脂酰膽堿膠囊,觀察組在對照組治療基礎(chǔ)上給予速效降脂舒肝湯。治療結(jié)束后,比較兩組血脂、肝功能以及肝纖維化指標(biāo)的變化,觀察肝臟B超和肝臟及脾臟CT檢查的變化,并比較臨床療效。結(jié)果:與治療前比較,兩組總膽固醇(total cholesterol,TC)、三酰甘油(triacylglycerol,TG)以及低密度脂蛋白(low density lipoprotein,LDL)水平降低(P0.01),高密度脂蛋白(high density lipoprotein,HDL)水平升高(P0.01),總膽紅素(total bilirubin,TBIL)、γ-谷氨酰轉(zhuǎn)肽酶(gamma-glutamyl transpeptidase,γ-GT)、丙氨酸轉(zhuǎn)氨酶(alanine aminotransferase,ALT)以及天門冬氨酸氨基轉(zhuǎn)移酶(aspartate amino transferase,AST)水平均降低(P0.01),血清層黏蛋白(laminin,LN)、透明質(zhì)酸(hyaluronic acid,HA)、Ⅲ型前膠原(procollagen III,PCⅢ)以及Ⅳ型膠原(collagen type IV,Ⅳ-C)水平均降低(P0.01),肝臟B超積分降低(P0.01),肝脾CT比值升高(P0.01);與對照組比較,觀察組TC、TG以及LDL水平較低(P0.01),HDL水平較高(P0.01),TBIL、γ-GT、ALT以及AST水平均較低(P0.01),LN、HA、PCⅢ以及Ⅳ-C水平均較低(P0.01),肝臟B超積分較低(P0.01),肝脾CT比值較高(P0.01);對照組有效率為48.72%,觀察組有效率為76.92%,兩組有效率比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:速效降脂舒肝湯治療非酒精性脂肪性肝炎臨床療效顯著,能抑制肝纖維化,改善肝臟影像學(xué)及肝功能。
[Abstract]:Objective: to observe the clinical effect of quick-acting Jiangzhi Shugan decoction on non-alcoholic fatty liver. Methods: 78 patients with non-alcoholic fatty hepatitis were randomly divided into control group and observation group with 39 cases in each group. The control group was given Polyene phosphatidylcholine capsule, and the observation group was given the quick-acting Jiangzhi Shugan decoction on the basis of the treatment in the control group. After the treatment, the changes of serum lipids, liver function and hepatic fibrosis were compared between the two groups, and the changes of liver B-ultrasound and CT examination of liver and spleen were observed, and the clinical efficacy was compared. Results: compared with before treatment, the levels of total cholesterol (total cholesterol,TC), triglyceride (triacylglycerol,TG) and low density lipoprotein (low density lipoprotein,LDL) were decreased (P0.01) and high density lipoprotein (high density lipoprotein,) in both groups. Increased levels of HDL, total bilirubin (total bilirubin,TBIL), gamma-glutamyl transpeptidase, 緯 GT), alanine aminotransferase (alanine aminotransferase,ALT) and aspartate aminotransferase (aspartate amino transferase, The levels of serum laminin (laminin,LN), hyaluronic acid (hyaluronic acid,HA), type 鈪，

本文編號(hào)：2394003