糖痹消治療糖尿病周圍神經(jīng)病變臨床療效觀察
發(fā)布時間：2018-12-23 08:04
【摘要】：目的:本試驗研究旨在觀察臨床經(jīng)驗方糖痹消在治療糖尿病周圍神經(jīng)病變的有效性和安全性,為糖尿病周圍神經(jīng)病變的治療提供臨床依據(jù)。材料與方法:選取60例營口市中醫(yī)院糖尿病門診患者,確診為糖尿病周圍神經(jīng)病變,且依據(jù)《糖尿病中醫(yī)防治指南》辨證屬氣虛血瘀證型。將患者分為試驗組與對照組,其中試驗組30例,對照組30例。試驗組給予基礎(chǔ)降糖治療聯(lián)合糖痹消水煎劑100ml日三次口服;對照組給予基礎(chǔ)降糖治療聯(lián)合甲鈷胺膠囊0.5mg日三次口服,療程四周,觀察試驗組和對照組的中醫(yī)證候積分,Toronto積分,血脂,血糖的變化。結(jié)果:1.治療結(jié)束后,兩組Toronto積分間療效的綜合比較,試驗組的總有效率90%,對照組的總有效率為73.33%,兩組比較有顯著性差異,結(jié)果具有統(tǒng)計學(xué)意義(P0.05),試驗組優(yōu)于對照組。2.治療結(jié)束后,兩組中醫(yī)證候積分療效的綜合比較,試驗組的總有效率為86.67%,對照組的總有效率為63.33%,兩組相比,差異顯著。結(jié)果具有統(tǒng)計學(xué)意義(P0.05),試驗組優(yōu)于對照組。3.兩組Toronto積分比較,兩組較治療前有改善,差異具有統(tǒng)計學(xué)意義(P0.05),治療后試驗組與對照組比較,差異顯著(P0.05)。4.兩組中醫(yī)癥狀積分比較,兩組較治療前有改善,差異具有統(tǒng)計學(xué)意義(P0.05),治療后試驗組與對照組比較,存在明顯差異(P0.05)。5.治療結(jié)束后,試驗組和對照組在空腹血糖、餐后兩小時血糖、血脂方面無明顯差異(P0.05)。6.治療結(jié)束后,在ALT,AST,尿素,肌酐方面,試驗組和對照組無統(tǒng)計學(xué)差異(P0.05)。結(jié)論:1.“糖痹消復(fù)方”能夠有效改善糖尿病周圍神經(jīng)病變患者的臨床癥狀,降低糖尿病患者的周圍神經(jīng)病變Toronto評分和中醫(yī)證候積分,且安全性良好。
[Abstract]:Objective: to observe the efficacy and safety of Fangtang Bixiao in the treatment of diabetic peripheral neuropathy and to provide clinical basis for the treatment of diabetic peripheral neuropathy. Materials and methods: 60 patients with diabetes mellitus in Yingkou traditional Chinese Medicine Hospital were diagnosed as diabetic peripheral neuropathy, and according to the guidelines for the Prevention and treatment of Diabetes in TCM, the syndrome differentiation belonged to qi deficiency and blood stasis syndrome. The patients were divided into experimental group (30 cases) and control group (30 cases). The experimental group was given basic hypoglycemic therapy combined with Tangbixiao decoction 100ml three times a day oral; The control group was given basic hypoglycemic therapy combined with megalobalamin capsule 0.5mg three times a day for four weeks. The changes of TCM syndrome score, Toronto score, blood lipid and blood glucose were observed in the experimental group and the control group. Results: 1. After the treatment, the total effective rate of the experimental group was 90, and the total effective rate of the control group was 73.33. There was a significant difference between the two groups, the results were statistically significant (P0.05). The experimental group was superior to the control group. 2. After the treatment, the total effective rate of the experimental group was 86.67 and that of the control group was 63.333.The difference between the two groups was significant. The results were statistically significant (P0.05). The experimental group was better than the control group. Compared with the two groups, the Toronto scores of the two groups were improved, the difference was statistically significant (P0.05), and the difference between the experimental group and the control group was significant (P0.05) after treatment (P0.05). Two groups of TCM symptom scores, the two groups were improved before treatment, the difference was statistically significant (P0.05), after treatment, there was a significant difference between the experimental group and the control group (P0.05). After treatment, there was no significant difference in fasting blood glucose, 2 hours postprandial blood glucose and blood lipid between the experimental group and the control group (P0.05). After treatment, there was no significant difference in ALT,AST, urea and creatinine between the test group and the control group (P0.05). Conclusion: 1. "Tangbixiao compound" can effectively improve the clinical symptoms of patients with diabetic peripheral neuropathy, reduce the Toronto score and TCM syndromes score of diabetic patients with peripheral neuropathy, and the safety is good.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R259;R277.7
本文編號：2389664
[Abstract]:Objective: to observe the efficacy and safety of Fangtang Bixiao in the treatment of diabetic peripheral neuropathy and to provide clinical basis for the treatment of diabetic peripheral neuropathy. Materials and methods: 60 patients with diabetes mellitus in Yingkou traditional Chinese Medicine Hospital were diagnosed as diabetic peripheral neuropathy, and according to the guidelines for the Prevention and treatment of Diabetes in TCM, the syndrome differentiation belonged to qi deficiency and blood stasis syndrome. The patients were divided into experimental group (30 cases) and control group (30 cases). The experimental group was given basic hypoglycemic therapy combined with Tangbixiao decoction 100ml three times a day oral; The control group was given basic hypoglycemic therapy combined with megalobalamin capsule 0.5mg three times a day for four weeks. The changes of TCM syndrome score, Toronto score, blood lipid and blood glucose were observed in the experimental group and the control group. Results: 1. After the treatment, the total effective rate of the experimental group was 90, and the total effective rate of the control group was 73.33. There was a significant difference between the two groups, the results were statistically significant (P0.05). The experimental group was superior to the control group. 2. After the treatment, the total effective rate of the experimental group was 86.67 and that of the control group was 63.333.The difference between the two groups was significant. The results were statistically significant (P0.05). The experimental group was better than the control group. Compared with the two groups, the Toronto scores of the two groups were improved, the difference was statistically significant (P0.05), and the difference between the experimental group and the control group was significant (P0.05) after treatment (P0.05). Two groups of TCM symptom scores, the two groups were improved before treatment, the difference was statistically significant (P0.05), after treatment, there was a significant difference between the experimental group and the control group (P0.05). After treatment, there was no significant difference in fasting blood glucose, 2 hours postprandial blood glucose and blood lipid between the experimental group and the control group (P0.05). After treatment, there was no significant difference in ALT,AST, urea and creatinine between the test group and the control group (P0.05). Conclusion: 1. "Tangbixiao compound" can effectively improve the clinical symptoms of patients with diabetic peripheral neuropathy, reduce the Toronto score and TCM syndromes score of diabetic patients with peripheral neuropathy, and the safety is good.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R259;R277.7
【參考文獻】
相關(guān)期刊論文 前10條
1 鄧雅婷;李競;;糖尿病周圍神經(jīng)病變綜合性治療進展[J];中國藥師;2017年02期
2 周昊玲;顏燦群;;糖尿病周圍神經(jīng)病變的研究進展[J];西南軍醫(yī);2017年01期
3 劉爽;;黃芪藥理作用的研究進展[J];北方藥學(xué);2015年12期
4 趙秋艷;;川芎鑒定及臨床應(yīng)用分析[J];中國衛(wèi)生標準管理;2015年09期
5 黃慶勇;李煌;許文;徐偉;張玉琴;褚克丹;陳嫻雯;謝施恩;;君藥天花粉對復(fù)方栝樓桂枝湯中9種成分的影響[J];中國實驗方劑學(xué)雜志;2014年12期
6 陸祖謙;丁維;;糖尿病周圍神經(jīng)病變診治進展[J];藥品評價;2013年17期
7 付慶林;饒高峰;;甲鈷胺聯(lián)合前列地爾治療2型糖尿病周圍神經(jīng)病變的療效與安全性[J];中國臨床藥理學(xué)雜志;2012年07期
8 謝寶強;周青美;;甲鈷胺與法舒地爾聯(lián)合治療糖尿病周圍神經(jīng)病變的療效[J];中國老年學(xué)雜志;2012年05期
9 施君;張文川;;糖尿病周圍神經(jīng)病變發(fā)病機制的研究進展[J];上海交通大學(xué)學(xué)報(醫(yī)學(xué)版);2012年01期
10 龐國明;閆鏞;鄭曉東;;糖尿病周圍神經(jīng)病變中醫(yī)防治指南[J];中國中醫(yī)藥現(xiàn)代遠程教育;2011年22期
，本文編號：2389664
本文鏈接：http://sikaile.net/zhongyixuelunwen/2389664.html
最近更新
教材專著
