【摘要】：目的:運(yùn)用關(guān)聯(lián)規(guī)則分析方法挖掘和分析緊張型頭痛中醫(yī)用藥特點(diǎn)及配伍規(guī)律,為臨床用藥提供參考,開(kāi)拓用藥思路。方法:搜集2000年-2014年符合納入標(biāo)準(zhǔn)的文獻(xiàn)中中醫(yī)藥治療緊張型頭痛的方劑,選用內(nèi)治方劑作為數(shù)據(jù)集,運(yùn)用SPSS Clementine 12.0數(shù)據(jù)挖掘軟件對(duì)其藥物進(jìn)行關(guān)聯(lián)規(guī)則分析,選用關(guān)聯(lián)規(guī)則Apriori算法建立數(shù)據(jù)挖掘模型,最小支持度為10%,最小置信度為80%,并運(yùn)用Web節(jié)點(diǎn)對(duì)藥物配伍組合進(jìn)行展示。結(jié)果:符合標(biāo)準(zhǔn)的治療緊張型頭痛方劑共162首,所用藥物共171味,總頻次2308次,使用頻數(shù)在20次以上的藥物共40味,共使用1646次,占藥物使用總頻數(shù)的71.33%。其中解表藥應(yīng)用頻次最高,為517次,占總頻次的22.40%,其后依次為:補(bǔ)虛藥、活血化瘀藥、平肝熄風(fēng)藥、清熱藥、安神藥、理氣藥、化痰止咳平喘藥、利水滲濕藥、祛風(fēng)濕藥等。共得到符合條件的藥物關(guān)聯(lián)規(guī)則393條,其中包含川芎的規(guī)則最多,為282條,規(guī)則支持度大于30.00%的規(guī)則有:白芍→川芎、柴胡→川芎、當(dāng)歸→川芎、白芷→川芎、葛根→川芎、天麻→川芎、柴胡+白芍→川芎、當(dāng)歸+白芍→川芎、白芷+白芍→川芎、當(dāng)歸+柴胡→川芎。結(jié)論:緊張型頭痛的治療以風(fēng)藥為主,臨床上風(fēng)藥與風(fēng)藥,風(fēng)藥與白芍、活血化瘀藥等常相須為用。川芎為治療緊張型頭痛的要藥,其配伍較為靈活。關(guān)聯(lián)規(guī)則分析,可用于方劑數(shù)據(jù)庫(kù)中藥物配伍規(guī)律的挖掘研究,從而為臨床用藥提供依據(jù)和思路。
[Abstract]:Objective: to explore and analyze the characteristics and compatibility of traditional Chinese medicine (TCM) for tension headache by using association rule analysis method, to provide reference for clinical use of drugs and to develop the thinking of drug use. Methods: the prescriptions of traditional Chinese medicine (TCM) for the treatment of tension-type headache, which met the inclusion standard from 2000 to 2014, were collected. The internal prescription was selected as the data set, and the association rules of the drugs were analyzed by using SPSS Clementine 12.0 data mining software. The association rule Apriori algorithm is used to build a data mining model with a minimum support of 10 and a minimum confidence of 80. The combination of drug compatibility is demonstrated by Web node. Results: a total of 162 prescriptions were used to treat tension headache. The total frequency was 2308 times. 40 kinds of drugs were used more than 20 times, 1646 times, accounting for 71.33% of the total frequency of drug use. Among them, the antidote is the most frequently used, 517 times, accounting for 22.40 times of the total frequency, followed by: tonifying medicine, activating blood circulation and removing stasis medicine, calming the liver and eliminating wind medicine, clearing away heat medicine, tranquilizing spirit medicine, regulating qi medicine, eliminating phlegm and relieving cough and relieving asthma medicine, promoting water and seepage medicine, Antirheumatic medicine, etc. A total of 393 drug association rules were obtained, including 282 rules containing Chuanxiong, including Ligusticum lanceolata, Radix Bupleurum, Radix angelicae dahurica, Chuanxiong chuanxiong, and Radix angelicae dahuricae. Radix Puerariae, Gastrodia elata, Radix Bupleurum, Radix angelicae Alba, Radix angelicae Alba, Conclusion: the main treatment of tension headache is wind medicine, wind medicine and white peony root, promoting blood circulation and removing blood stasis. Chuanxiong for the treatment of tension headache, its compatibility is more flexible. The analysis of association rules can be used to mine the law of drug compatibility in prescription database, thus providing the basis and train of thought for clinical use of drugs.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R277.7

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