【摘要】：目的:基于目前現(xiàn)有的文獻(xiàn),評(píng)價(jià)心脈通膠囊降壓療效的證據(jù)水平和強(qiáng)度,為撰寫中醫(yī)高血壓診療指南提供證據(jù)。方法:計(jì)算機(jī)檢索聯(lián)合手工檢索國(guó)內(nèi)外醫(yī)學(xué)雜志,搜集2005年1月-2016年1月發(fā)表的心脈通膠囊治療高血壓的臨床隨機(jī)對(duì)照試驗(yàn)(RCTs),限定中、英文語(yǔ)種。按照Cochrane協(xié)作等推薦的方法評(píng)價(jià)納入研究的方法學(xué)質(zhì)量,提取有效數(shù)據(jù)后,采用Revman5.3軟件進(jìn)行Meta分析。結(jié)果:共納入7個(gè)文獻(xiàn)研究,包括860例患者的臨床隨機(jī)對(duì)照試驗(yàn)。Meta分析結(jié)果顯示:單用心脈通膠囊在降壓療效方面與化學(xué)藥物相比,組間差異有顯著性;在改善證候方面優(yōu)于化學(xué)藥物,組間差異有顯著性;心脈通膠囊與化學(xué)藥物聯(lián)合應(yīng)用在降壓療效、改善血脂水平方面和化學(xué)藥物相比,組間差異有顯著性。結(jié)論:心脈通膠囊具有降壓作用,平均比尼莫地平降低收縮壓多6mmHg,降低舒張壓多5mmHg;能較好的改善患者癥狀,在證屬氣陰兩虛、肝陽(yáng)上亢、痰濁壅盛的高血壓患者治療中療效顯著;具有一定的改善血脂的作用,可以降低血清膽固醇(TC),但作用不穩(wěn)定,降低甘油三酯(TG)的作用微弱;無(wú)明顯副作用,與化學(xué)藥物聯(lián)合應(yīng)用可以降低服用降壓藥引起的頭痛、頭脹、水腫、焦慮等副作用的發(fā)生,從而提高患者的服藥依從性。GRADE證據(jù)分級(jí)為Ib級(jí)證據(jù),有選擇性的推薦。
[Abstract]:Objective: to evaluate the evidence level and strength of the antihypertensive effect of Xinmaitong capsule based on the current literature, and to provide evidence for the writing of the guidelines for the diagnosis and treatment of hypertension in traditional Chinese medicine. Methods: the Chinese and English languages of clinical randomized controlled trial of Xinmaitong capsule for the treatment of hypertension were collected from January 2005 to January 2016 by computer retrieval combined with manual retrieval of Chinese and English medical journals. According to the recommended methods of Cochrane collaboration, the quality of the methodology was evaluated, and the valid data were extracted, and the Meta analysis was carried out by using Revman5.3 software. Results: a total of 7 literature studies were conducted, including 860 clinical randomized controlled trials. The results of Meta analysis showed that there was a significant difference between the two groups in the antihypertensive effect of Monoru Maitong capsule compared with that of chemical drugs. The effect of Xinmaitong capsule combined with chemical drugs on reducing blood pressure and improving blood lipid level was significantly different from that of chemical drugs. Conclusion: Xinmaitong capsule has the effect of lowering blood pressure. Compared with nimodipine, Xinmaitong capsule can decrease systolic blood pressure and diastolic blood pressure by 6 mm / g and 5 mm / g respectively. Can improve the symptoms of patients, in the syndrome of deficiency of qi and yin, hyperactivity of liver yang, phlegm turbid in the treatment of hypertension patients have a significant effect; It can reduce serum cholesterol (TC), but its effect is unstable and triglyceride (TG) has weak effect. Without obvious side effects, combined with chemical drugs can reduce the incidence of headache, head distension, edema, anxiety and other side effects caused by antihypertensive drugs, thus improving the compliance of patients. GRADE evidence is classified as Ib grade evidence. Selective recommendation.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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