【摘要】：目的:通過流行病學(xué)調(diào)查,了解沈陽(yáng)市某大型國(guó)企職工高尿酸血癥患病率,研究發(fā)病人群年齡特點(diǎn),分析其相關(guān)危險(xiǎn)因素,探究其中醫(yī)體質(zhì)分型病因病機(jī)特點(diǎn)。材料與方法:研究對(duì)象選自在2016年9月至2016年12月參加公司體檢的沈陽(yáng)市某大型國(guó)企車身組裝車間1297名職工,經(jīng)流行病學(xué)調(diào)查,符合入選研究標(biāo)準(zhǔn)的高尿酸血癥患者216例。根據(jù)中華中醫(yī)藥學(xué)會(huì)《中醫(yī)體質(zhì)分類與判定》標(biāo)準(zhǔn)歸納入選病例的中醫(yī)體質(zhì)分型。采用SPSS17.0統(tǒng)計(jì)軟件處理相關(guān)數(shù)據(jù),各中醫(yī)體質(zhì)分型間比較用秩和檢驗(yàn),高尿酸血癥的相關(guān)危險(xiǎn)因素用多因素Logistic回歸分析,P0.05為差異有統(tǒng)計(jì)學(xué)意義。結(jié)果:1.經(jīng)流行病學(xué)調(diào)查發(fā)現(xiàn),高尿酸血癥患者216例,患病率為16.95%,均為男性,年齡為(32.77±3.91)歲,血尿酸水平為(515.85±69.93)ummol/L.2.HUA患者中醫(yī)體質(zhì)各辯證分型分布情況:濕熱質(zhì)68例(31.48%)、血瘀質(zhì)63例(29.16%)、痰濕質(zhì)47例(21.75%)、平和質(zhì)38例(17.59%)。3.HUA患者采用中醫(yī)藥干預(yù)例數(shù)為43例,干預(yù)率為19.9%。采用西藥干預(yù)例數(shù)為29例,干預(yù)率為13.4%。4.經(jīng)多因素Logisitc回歸分析得出,高嘌呤飲食(OR=1.737,OR95%CI:1.153-2.615)、TG(OR=1.258,OR95%CI:0.966-1.638)、LDL-C(OR=1.811,OR95%CI:1.390-2.358)與HUA的發(fā)生具有顯著相關(guān)性(P0.05),是HUA的危險(xiǎn)因素。結(jié)論:1.該大型國(guó)企職工HUA患病率有上升趨勢(shì),而且中青年發(fā)病人數(shù)較往年增加。2.HUA患者中醫(yī)體質(zhì)分型分布由高到低依次為次為濕熱質(zhì)、血瘀質(zhì)、痰濕質(zhì)、平和質(zhì)。3.在HUA患者中,使用中藥或藥膳干預(yù)HUA多于使用西藥干預(yù)。4.高嘌呤飲食、TG、LDL-C是HUA的危險(xiǎn)因素,HUA患者今后應(yīng)控制高嘌呤食物攝入、定期監(jiān)測(cè)血脂、血尿酸水平。
[Abstract]:Objective: to investigate the prevalence of hyperuricemia in workers of a large state-owned enterprise in Shenyang through epidemiological investigation, to study the age characteristics of the affected population, to analyze the related risk factors, and to explore the etiology and pathogenesis of TCM physique classification. Materials and methods: from September 2016 to December 2016, 1297 employees of a large state-owned enterprise body assembly workshop in Shenyang were enrolled in the physical examination. According to the epidemiological investigation, 216 patients with hyperuricemia were enrolled in the study. According to the criteria of TCM constitution classification and judgment, the selected cases were classified. SPSS17.0 statistical software was used to process the relevant data. The rank sum test was used to compare the physique types of TCM and the risk factors of hyperuricemia were analyzed by multivariate Logistic regression analysis. The difference was statistically significant (P0.05). Results: 1. The epidemiological investigation showed that 216 patients with hyperuricemia had a prevalence rate of 16.955.They were all males with an age of (32.77 鹵3.91) years. The level of serum uric acid was (515.85 鹵69.93). The distribution of TCM physique in ummol/L.2.HUA patients was as follows: 68 cases (31.48%) of dampness and heat, 63 cases (29.16%) of blood stasis, 47 cases (21.75%) of phlegm dampness. 38 cases (17.59%) were mild, 43 cases were treated with traditional Chinese medicine (TCM), the intervention rate was 19.9%. 29 cases were treated with western medicine, the intervention rate was 13. 4. 4. Multivariate Logisitc regression analysis showed that high purine diet (OR=1.737,OR95%CI:1.153-2.615), TG (OR=1.258,OR95%CI:0.966-1.638), LDL-C (OR=1.811,) OR95%CI:1.390-2.358) was significantly correlated with the occurrence of HUA (P 0.05) and was a risk factor for HUA. Conclusion: 1. The prevalence rate of HUA in the workers of this large state-owned enterprise is on the rise, and the number of young and middle-aged patients has increased compared with previous years. The distribution of TCM physique type of 2.HUA patients from high to low is dampness and heat, blood stasis, phlegm and dampness, and calmness. 3. In patients with HUA, intervention of HUA with traditional Chinese medicine or medicinal meal was more than intervention with western medicine. 4. 4. High purine diet, TG,LDL-C is the risk factor of HUA, HUA patients should control high purine food intake, regular monitoring of blood lipids and serum uric acid levels.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R259

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