【摘要】：目的觀察腎炎消白顆粒治療原發(fā)性腎小球腎炎蛋白尿的臨床療效,為臨床治療腎小球腎炎蛋白尿提供可行有效的方法,為臨床用藥提供良好的依據(jù)。方法選黑龍江省中醫(yī)醫(yī)院腎病科門(mén)診2014年5月~2015年12月滿(mǎn)足條件的慢性腎小球腎炎患者90例,隨機(jī)分成治療組與對(duì)照組,每組各45例,治療組在給予常規(guī)治療基礎(chǔ)上加用腎炎消白顆粒,對(duì)照組在常規(guī)治療基礎(chǔ)上服用腎炎康復(fù)片,每4周為1個(gè)療程,觀察3個(gè)療程,分別在治療前后檢測(cè)相關(guān)指標(biāo),并分析指標(biāo)的變化及意義。結(jié)果在整個(gè)試驗(yàn)的各時(shí)間點(diǎn)時(shí),治療組與對(duì)照組各項(xiàng)指標(biāo)(24小時(shí)尿蛋白定量、中醫(yī)癥候積分、尿微量白蛋白/尿肌酐、尿足細(xì)胞含量)均變化明顯,有統(tǒng)計(jì)學(xué)意義(p0.01)。試驗(yàn)4周與12周時(shí),治療組與對(duì)照組患者兩組療效相當(dāng),無(wú)統(tǒng)計(jì)學(xué)意義(p0.05);8周時(shí)各指標(biāo)亦均下降,其中治療組24小時(shí)尿蛋白定量有效率、尿微量白蛋白/尿肌酐有效率較對(duì)照組變化明顯,有統(tǒng)計(jì)學(xué)意義(p0.05);12周時(shí),治療組24小時(shí)尿蛋白定量較對(duì)照組下降明顯,有統(tǒng)計(jì)學(xué)意義(p0.05);未出現(xiàn)肝腎功能損害。結(jié)論腎炎消白顆粒能減少慢性腎小球腎炎患者24小時(shí)尿蛋白定量;降低尿微量白蛋白/尿肌酐;減少尿中足細(xì)胞的含量;改善患者的臨床癥狀,提高患者的生活質(zhì)量;治療組有效率有優(yōu)于對(duì)照組的趨勢(shì)。
[Abstract]:Objective to observe the clinical efficacy of Shenyan Xiaobai granule in the treatment of primary glomerulonephritis proteinuria, to provide a feasible and effective method for the clinical treatment of glomerulonephritis proteinuria, and to provide a good basis for clinical use of drugs. Methods from May 2014 to December 2015, 90 patients with chronic glomerulonephritis were randomly divided into treatment group (n = 45) and control group (n = 45). On the basis of routine treatment, the treatment group was treated with Shenyan Xiaobai granule, and the control group was treated with nephritis rehabilitation tablet on the basis of routine treatment. The treatment group was treated with one course of treatment every 4 weeks, and three courses of treatment were observed, and the related indexes were detected before and after treatment. And analyze the change and significance of the index. Results at each time point of the whole experiment, the indexes of the treatment group and the control group (24 hours urine protein quantity, TCM symptom score, urinary microalbumin / urine creatinine, urine podocyte content) all changed obviously. There was statistical significance (p 0.01). At the 4th week and 12th week, the curative effect of the treatment group and the control group was the same, but there was no significant difference between the treatment group and the control group (p0.05). At the 8th week, the indexes also decreased. The effective rate of 24 hours urine protein quantification in the treatment group was significantly higher than that of the control group (p0.05). The effective rate of urinary microalbumin / creatinine in the treatment group was significantly higher than that in the control group (p0.05). At 12 weeks, the urine protein quantity in the treatment group was significantly lower than that in the control group (p0.05), and no damage of liver and kidney function was found in the treatment group. Conclusion Shenyanxiaobai granule can reduce 24 hours urinary protein quantity, reduce urinary microalbumin / urinary creatinine, decrease the content of podocyte in urine, improve clinical symptoms and improve the quality of life of patients with chronic glomerulonephritis. The effective rate of the treatment group was better than that of the control group.
【學(xué)位授予單位】：黑龍江省中醫(yī)藥科學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R277.5
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本文編號(hào)：2353339