【摘要】：目的:本課題通過(guò)對(duì)非感染性腹瀉(脾胃虛弱證)的臨床研究,探究調(diào)脾固腸湯對(duì)非感染性腹瀉(脾胃虛弱證)的臨床療效以及安全性。進(jìn)一步驗(yàn)證中醫(yī)辨證論治理論對(duì)非感染性腹瀉的治療作用。方法:本課題采用臨床開(kāi)放試驗(yàn)研究,選擇符合中醫(yī)診斷為泄瀉(脾胃虛弱證),且符合西醫(yī)診斷為非感染性腹瀉的患者。參照納入標(biāo)準(zhǔn),入選80例非感染性腹瀉患者,隨機(jī)分成治療組40例以及對(duì)照組40例。治療組口服調(diào)脾固腸湯,(太子參30g、茯苓30g、粉葛30g、懷山藥30g、炒薏苡仁30g、蓮子15g、防風(fēng)15g、炒白術(shù)15g、半枝蓮15g、仙鶴草10g、車前草10g--均選用云南省中醫(yī)醫(yī)院中藥房煎藥機(jī)統(tǒng)一煎藥),150ml/次,3次/日,每日1劑;對(duì)照組予以口服參苓白術(shù)顆粒治療,1日3次,每次1袋(6g),口服。兩組患者都以治療2周(開(kāi)始與結(jié)束作為治療介點(diǎn))作為觀察治療療程。均以服用藥2周后,再分別觀察、記錄:(1)分別記錄兩組患者的療效指標(biāo)(治療前、后)。(2)兩組患者治療前后的安全性指標(biāo)。結(jié)果:本課題選取研究病例為80例,當(dāng)中包含治療組40例(實(shí)際39例);及對(duì)照組40例(實(shí)際39例)。最終治療組因未按規(guī)定時(shí)間就診的,脫落1例;對(duì)照組中經(jīng)審核,不符合治療方案的,剔除1例。結(jié)果顯示:治療組和對(duì)照組的總有效率分別為92.3%,71.8%,經(jīng)比較差異有顯著性(P0.05)統(tǒng)計(jì)學(xué)意義;兩組患者在治療期間(一個(gè)療程2周)內(nèi),血尿便常規(guī)、肝功、腎功及心電圖觀察,均未發(fā)現(xiàn)異常改變,提示治療安全性可靠。結(jié)論:調(diào)脾固腸湯在改善非感染性腹瀉(脾胃虛弱證)的臨床證候方面確有療效,參苓白術(shù)顆粒有效;治療組中藥調(diào)脾固腸湯在改善大便次數(shù)、糞便性質(zhì)、腸鳴證候方面優(yōu)于對(duì)照組。而在改善食少納呆、脘腹悶痛、神疲倦怠試驗(yàn)組與對(duì)照組無(wú)差異性,且未發(fā)現(xiàn)明顯的副作用,可以將其作為治療非感染性腹瀉(脾胃虛弱證)的用藥選擇及參考。
[Abstract]:Objective: to investigate the clinical efficacy and safety of Tiaopi Guchang decoction in treating non-infectious diarrhea (deficiency of spleen and stomach). Further verify the therapeutic effect of TCM syndrome differentiation theory on non-infectious diarrhea. Methods: open clinical trial was used to select the patients with diarrhea (spleen and stomach weakness syndrome) and non infectious diarrhea diagnosed by western medicine. According to the inclusion criteria, 80 patients with non-infectious diarrhea were randomly divided into treatment group (n = 40) and control group (n = 40). In the treatment group, 30 g of Radix Pseudostellariae, 30g of Poria cocos, 30g of Pink Pueraria, 30g of yam, 30g of Coix seed, 15g of Fangfeng, 15g of Atractylodes macrocephala, 15g of Scutellaria davidii, 10g of Herba Cassia were taken orally in the treatment group. Plantain 10g-all selected traditional Chinese Medicine Hospital of Yunnan Province decoction machine unified decoction), 150ml/ times, 3 times a day, 1 dose per day; The control group was treated with Shenling Atractylodes granules, 3 times a day, 1 bag (6 g), orally. Both groups were treated for 2 weeks. After taking the drug for 2 weeks, we observed and recorded: (1) the efficacy index (before and after). (2) of the two groups of patients were recorded before and after treatment. Results: there were 80 cases in this study, including 40 cases in the treatment group (39 cases) and 40 cases in the control group (39 cases). In the final treatment group, 1 case dropped out because of not seeing a doctor in accordance with the prescribed time, and 1 case was excluded in the control group after examination, which did not conform to the treatment plan. The results showed that the total effective rates of the treatment group and the control group were 92.3% and 71.8, respectively. The difference was statistically significant (P0.05). There were no abnormal changes in hematuria routine, liver function, renal function and electrocardiogram during the treatment period (a course of 2 weeks) in both groups, indicating that the treatment was safe and reliable. Conclusion: Tiaopi Guchang decoction is effective in improving the clinical symptoms of non-infectious diarrhea (spleen and stomach deficiency syndrome), and Shenling Baizhu granule is effective. The treatment group was superior to the control group in improving defecation times, fecal properties and bowel syndrome. However, there was no difference between the experimental group and the control group in improving food intake, stomachache, and fatigue, and no obvious side effects were found, which could be used as a drug choice and reference for the treatment of non-infectious diarrhea (spleen and stomach weakness syndrome).
【學(xué)位授予單位】：云南中醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R259

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 陳慧;高雅文;林紅;;葛根芩連湯加味治療晚期結(jié)腸癌化療相關(guān)性腸道濕熱型腹瀉46例[J];浙江中醫(yī)雜志;2014年06期

2 羅淑紅;袁征;陳曉婷;;十灰散灌腸治療急性放射性腸炎28例[J];河南中醫(yī);2014年06期

3 趙勁枝;;白頭翁湯治療腹瀉型腸易激綜合征60例觀察[J];實(shí)用中醫(yī)藥雜志;2014年05期

4 楊紹芬;;谷氨酰胺強(qiáng)化腸內(nèi)營(yíng)養(yǎng)治療非感染性腹瀉臨床療效分析[J];昆明醫(yī)科大學(xué)學(xué)報(bào);2014年05期

5 張志安;;痛瀉要方脈證研究[J];吉林中醫(yī)藥;2014年02期

6 孫曉東;陳濤;;參苓白術(shù)散治療腸易激惹綜合征脾虛濕盛型腹瀉43例[J];中國(guó)中醫(yī)藥現(xiàn)代遠(yuǎn)程教育;2014年03期

7 郭紅;陸曉忠;包清;王芳;夏秋鈺;夏鏡菁;錢志堅(jiān);;隔姜灸治療腹瀉型腸易激綜合征50例[J];內(nèi)蒙古中醫(yī)藥;2013年28期

8 李天星;李新民;;中藥葛根的研究進(jìn)展[J];湖南中醫(yī)雜志;2013年08期

9 崔竹;;艾灸神闕治療腸內(nèi)營(yíng)養(yǎng)相關(guān)性腹瀉療效觀察[J];實(shí)用中醫(yī)藥雜志;2013年08期

10 玄寧;王會(huì)玲;殷錫香;陳蕾;;針灸結(jié)合益氣升陽(yáng)健脾湯治療慢性功能性腹瀉療效觀察[J];中國(guó)冶金工業(yè)醫(yī)學(xué)雜志;2013年03期

相關(guān)碩士學(xué)位論文 前1條

1 楊照坤;泄瀉病證的古今文獻(xiàn)研究與學(xué)術(shù)源流探討[D];北京中醫(yī)藥大學(xué);2008年

，

本文編號(hào)：2346607