基于GLP-1的作用機(jī)制對(duì)“連術(shù)消渴方”治療痰熱互結(jié)型消渴�。�2型糖尿病）的臨床研究
發(fā)布時(shí)間：2018-11-19 19:39
【摘要】：目的:通過(guò)對(duì)66例痰熱互結(jié)型消渴病(2型糖尿病(T2DM))患者的臨床療效觀察,初步評(píng)價(jià)連術(shù)消渴方治療消渴病的作用機(jī)制及是否安全,為中醫(yī)藥治療消渴病提供了新的方向。方法:隨機(jī)選取開(kāi)封市中醫(yī)院內(nèi)分泌科門診符合診斷標(biāo)準(zhǔn)的T2DM患者66例。所有病人均給予糖尿病基礎(chǔ)知識(shí)宣教,制定合理的飲食及運(yùn)動(dòng)治療處方。在基礎(chǔ)治療前提下,停用原口服降糖藥物兩周后,改為連術(shù)消渴方顆粒劑每日一劑分兩次水沖服用�？梢愿鶕�(jù)實(shí)際情況對(duì)藥物劑量增減。觀察周期為一個(gè)月。觀察治療前后患者的臨床癥狀、空腹及餐后2h血糖(FPG、2h PG)、果糖胺(FMN)、胰高血糖素樣肽-1(GLP-1)、總膽固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)等的變化。結(jié)果:1.治療前后中醫(yī)癥候總療效為95.3%。患者的癥狀積分治療后較治療期下降明顯(P0.05)。2.治療后患者的FPG、2h PG、FMN水平較治療前明顯改善(P0.05)。3.患者治療后的FGLP-1、2h GLP-1水平較治療前升高,統(tǒng)計(jì)有顯著差異(P0.05)。4.治療后患者的TC、TG、LDL-C水平較治療前降低,統(tǒng)計(jì)學(xué)有差異(P0.05),HDL-C水平在治療后比治療前明顯升高(P0.05)。5.治療過(guò)程中患者的血、尿、糞常規(guī)檢驗(yàn)以及肝腎功能檢驗(yàn)都未出現(xiàn)明顯的異常。結(jié)論:連術(shù)消渴方能很好地改善痰熱互結(jié)型消渴病患者的癥狀和體征,能夠使GLP-1水平升高,可以降低FPG、2h PG、FMN水平,能夠有效調(diào)節(jié)脂代謝紊亂。并考慮連術(shù)消渴方的降糖作用可能與GLP-1的水平升高有關(guān)。
[Abstract]:Objective: to evaluate the mechanism and safety of Lianchuxiaoke prescription in treating diabetes mellitus (T2DM) by observing the clinical curative effect of 66 patients with type 2 diabetes mellitus (T2DM). It provides a new direction for the treatment of dysentery with traditional Chinese medicine (TCM). Methods: 66 patients with T2DM were randomly selected from the Department of Endocrinology of Kaifeng Chinese Medicine Hospital. All patients were given basic knowledge of diabetes education, the formulation of rational diet and exercise treatment prescriptions. Under the premise of basic treatment, after stopping the oral hypoglycemic drugs for two weeks, Lianchuxiaoke granule was taken twice a day by water. The dosage can be increased or decreased according to the actual situation. The observation period is one month. The clinical symptoms, FPG,2h PG), fructosamine (FMN), glucagon like peptide-1 (GLP-1), total cholesterol (TC), triglyceride (TG), were observed before and after treatment. Changes of high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C). The result is 1: 1. The total curative effect of TCM symptom before and after treatment was 95. 3%. The symptom score of the patients decreased significantly after treatment than in the treatment period (P0.05). The FPG,2h PG,FMN level of patients after treatment was significantly improved compared with that before treatment (P0.05). The level of FGLP-1,2h GLP-1 after treatment was significantly higher than that before treatment (P0.05). The level of TC,TG,LDL-C in patients after treatment was lower than that before treatment, there was statistical difference (P0.05), the level of HDL-C after treatment was significantly higher than that before treatment (P0.05). There were no significant abnormalities in blood, urine, feces and liver-kidney function. Conclusion: Lianchuxiaoke prescription can effectively improve the symptoms and signs of patients with phlegm-heat syndrome, increase the level of GLP-1, decrease the level of FPG,2h PG,FMN, and regulate the disorder of lipid metabolism effectively. The hypoglycemic effect of Lianzhouxiaoke prescription may be related to the increase of GLP-1 level.
【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R255.4
[Abstract]:Objective: to evaluate the mechanism and safety of Lianchuxiaoke prescription in treating diabetes mellitus (T2DM) by observing the clinical curative effect of 66 patients with type 2 diabetes mellitus (T2DM). It provides a new direction for the treatment of dysentery with traditional Chinese medicine (TCM). Methods: 66 patients with T2DM were randomly selected from the Department of Endocrinology of Kaifeng Chinese Medicine Hospital. All patients were given basic knowledge of diabetes education, the formulation of rational diet and exercise treatment prescriptions. Under the premise of basic treatment, after stopping the oral hypoglycemic drugs for two weeks, Lianchuxiaoke granule was taken twice a day by water. The dosage can be increased or decreased according to the actual situation. The observation period is one month. The clinical symptoms, FPG,2h PG), fructosamine (FMN), glucagon like peptide-1 (GLP-1), total cholesterol (TC), triglyceride (TG), were observed before and after treatment. Changes of high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C). The result is 1: 1. The total curative effect of TCM symptom before and after treatment was 95. 3%. The symptom score of the patients decreased significantly after treatment than in the treatment period (P0.05). The FPG,2h PG,FMN level of patients after treatment was significantly improved compared with that before treatment (P0.05). The level of FGLP-1,2h GLP-1 after treatment was significantly higher than that before treatment (P0.05). The level of TC,TG,LDL-C in patients after treatment was lower than that before treatment, there was statistical difference (P0.05), the level of HDL-C after treatment was significantly higher than that before treatment (P0.05). There were no significant abnormalities in blood, urine, feces and liver-kidney function. Conclusion: Lianchuxiaoke prescription can effectively improve the symptoms and signs of patients with phlegm-heat syndrome, increase the level of GLP-1, decrease the level of FPG,2h PG,FMN, and regulate the disorder of lipid metabolism effectively. The hypoglycemic effect of Lianzhouxiaoke prescription may be related to the increase of GLP-1 level.
【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R255.4
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