【摘要】：目的：觀察糖尿病腎病中醫(yī)證型規(guī)律,及初步探討其與腎功能、尿蛋白、血糖和血脂的相關(guān)性。方法：對(duì)335例DN患者的分期、中醫(yī)主證和標(biāo)證進(jìn)行分析統(tǒng)計(jì),并檢測(cè)24h尿蛋白定量、血尿素氮(BUN)、血肌酐(SCr)、糖化血紅蛋白(HbAlc)、總膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)。結(jié)果：臨床前期136例,早期102例,臨床期55例,終末期42例,其中臨床前期及早期患者中均為氣陰兩虛證發(fā)生率最高,其次為陰虛燥熱證,均未出現(xiàn)陰陽(yáng)兩虛證；臨床期、終末期患者中陰陽(yáng)兩虛證發(fā)生率上升至首位,分別占63.64%、80.95%。陰虛燥熱證和氣陰兩虛證患者的尿蛋白、BUN和SCr差異無統(tǒng)計(jì)學(xué)意義(p0.05)。而與陰虛燥熱證和氣陰兩虛證相比較,陰陽(yáng)兩虛證患者的尿蛋白、BUN、SCr、TC、TG、LDL-C明顯升高,差異有統(tǒng)計(jì)學(xué)意義(p＜0.01),但糖化血紅蛋白與中醫(yī)證型無關(guān)；與瘀血證比較,痰濕證及水濕證的尿蛋白、BUN、SCr、TC、 TG、LDL-C水平明顯升高,差異有統(tǒng)計(jì)學(xué)意義(p0.05或p0.01)。水濕證患者SCr水平高于痰濕證,二者相比較差異有統(tǒng)計(jì)學(xué)意義(p0.01)。結(jié)論：DN演變規(guī)律陰虛燥熱-氣陰兩虛-陰陽(yáng)兩虛。糖尿病腎病患者的尿蛋白、BUN、SCr、TC、TG、LDL-C水平與中醫(yī)證型可能存在一定的相關(guān)性。
[Abstract]:Objective: to investigate the relationship between diabetic nephropathy and renal function, urine protein, blood glucose and blood lipid. Methods: the staging, TCM main syndrome and standard syndrome of 335 patients with DN were analyzed and statistically analyzed, and 24 hours urine protein quantification, blood urea nitrogen (BUN), serum creatinine, (SCr), glycosylated hemoglobin, (HbAlc), total cholesterol (TC), were detected. Triglyceride (TG), low density lipoprotein (LDL-C). Results: 136 cases of pre-clinical stage, 102 cases of early stage, 55 cases of clinical stage and 42 cases of end-stage. In the clinical stage, the incidence of yin and yang deficiency syndrome increased to the first place, accounting for 63.64% and 80.955cm respectively. There was no significant difference in urine protein, BUN and SCr between patients with deficiency of Yin and deficiency of Qi and Yin (p0. 05). Compared with the syndrome of deficiency of Yin and deficiency of Qi and Yin, the urine protein and BUN,SCr,TC,TG,LDL-C of the patients with Yin and Yang deficiency were significantly increased (p < 0. 01), but glycosylated hemoglobin was not related to the type of TCM syndrome. Compared with blood stasis syndrome, the level of urine protein and BUN,SCr,TC, TG,LDL-C in phlegm-dampness syndrome and water-dampness syndrome were significantly increased (p0. 05 or p0. 01). The level of SCr in patients with water dampness syndrome was higher than that in phlegm dampness syndrome, and the difference was statistically significant (p 0.01). Conclusion: the law of DN evolution is deficiency of yin and heat, deficiency of qi and yin, deficiency of yin and yang. The level of urinary protein and BUN,SCr,TC,TG,LDL-C in diabetic nephropathy patients may be correlated with TCM syndrome type.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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