【摘要】：目的：觀測溫腎通絡(luò)止痛方三方對(duì)腎陽虛原發(fā)性骨質(zhì)疏松癥(Osteoporosis, OP)的治療效果,篩選出最佳的處方。方法：本研究采用隨機(jī)對(duì)照的原則,選擇符合納入標(biāo)準(zhǔn)的腎陽虛型原發(fā)性骨質(zhì)疏松患者32例,隨機(jī)分為溫腎通絡(luò)止痛方治療組A(A方8例)、治療組B(B方8例)、治療組C(C方8例)及對(duì)照組(8例),3個(gè)治療組分別予溫腎通絡(luò)止痛方治療,對(duì)照組采用基礎(chǔ)治療,4組治療時(shí)間均為2個(gè)月,對(duì)4組治療前、治療1月,2月的臨床癥狀及骨密度進(jìn)行數(shù)理統(tǒng)計(jì)分析,以觀察療效并篩選出最優(yōu)處方。結(jié)果：治療1月后溫腎通絡(luò)止痛方A組有效率62.5%,治療組B有效率75%,治療組C有效率87.5%,明顯優(yōu)于對(duì)照組有效率37.5%,比較組間差異有統(tǒng)計(jì)學(xué)意義。治療2月后治療組A顯效率0%、有效率100%,治療組B顯效率37.5%,有效率100%,治療組C顯效率12.5%、有效率100%,明顯優(yōu)于對(duì)照組顯效率0%,有效率75%,組間比較有顯著差異。治療組B顯效率明顯優(yōu)于治療組A和C。4組治療后,腰脊疼痛、腰膝酸軟無力、畏寒肢冷、下肢抽筋、步履艱難等癥狀均有好轉(zhuǎn),臨床癥狀積分明顯下降,且治療2月后治療組A、B、C與對(duì)照組相比有統(tǒng)計(jì)學(xué)差異(P0.05),治療組B與A、C比較有統(tǒng)計(jì)學(xué)差異(P0.05),明顯較優(yōu),治療前后骨密度改變無統(tǒng)計(jì)學(xué)意義(P0.05),治療前后血、尿、糞常規(guī)、肝腎功能、心電圖等安全性指標(biāo)未見明顯異常,各組用藥后未見明顯不良反應(yīng)。結(jié)論：溫腎通絡(luò)止痛方B治療腎陽虛原發(fā)性骨質(zhì)疏松癥療效更顯,能維持骨密度,改善臨床癥狀,無不良反應(yīng),能有效防治腎陽虛型骨質(zhì)疏松癥。
[Abstract]:Objective: to observe the therapeutic effect of Wenshen Tongluo Zhitong recipe on (Osteoporosis, OP) of primary osteoporosis due to deficiency of kidney-yang. Methods: in this study, 32 patients with primary osteoporosis of kidney-yang deficiency type were randomly divided into two groups: A (A prescription (n = 8) and B (B prescription (n = 8). The treatment group (8 cases) and the control group (8 cases) were treated with Wenshen Tongluo Zhitong recipe, the control group was treated with basic treatment, the 4 groups were treated for 2 months, and the 4 groups were treated for 1 month before treatment. The clinical symptoms and bone mineral density in 2 months were analyzed by mathematical statistics to observe the curative effect and to select the best prescription. Results: after one month of treatment, the effective rate of Wenshen Tongluo Zhitong Fang (group A) was 62.5, the effective rate of treatment group B was 75, and the effective rate of treatment group C was 87.5, which was obviously better than that of control group (37.5%). The difference between the two groups was statistically significant. After two months of treatment, the treatment group showed an effective rate 0 and an effective rate of 100. The treatment group B showed an effective rate of 37.5 and the effective rate was 100. The treatment group C showed an effective rate of 12.5 and the effective rate was 100. The effective rate was 100, which was obviously better than that of the control group. The markedly effective rate was 0, and the effective rate was 75. There were significant differences between groups. The effective rate of treatment group B was obviously better than that of group A and group C.4 after treatment, the pain of lumbar spine, weakness of waist and knee, chills of cold limbs, cramps of lower limbs, and treadmill were all improved, and the clinical symptom score was obviously decreased. After 2 months of treatment, there was a statistical difference between the treatment group and the control group (P0.05), and the treatment group B and Agna C had statistical difference (P0.05), which was significantly better than that of the control group (P0.05), and the treatment group B was significantly better than the control group (P0.05). Before and after treatment there was no significant change in bone mineral density (P0.05). Before and after treatment blood urine fecal routine liver and kidney function electrocardiogram and other safety indicators were not significantly abnormal. Conclusion: Wenshen Tongluo Zhitong recipe B is more effective in the treatment of primary osteoporosis due to deficiency of kidney yang. It can maintain bone mineral density, improve clinical symptoms, have no adverse reactions, and can effectively prevent and treat osteoporosis of kidney yang deficiency type.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 吳立文;;溫腎法運(yùn)用淺論[J];云南中醫(yī)雜志;1985年03期

2 張工_g;溫腎法的臨床運(yùn)用及其配伍規(guī)律[J];江蘇中醫(yī);1993年02期

3 張光泰;溫腎榮筋湯治療進(jìn)行性肌營養(yǎng)不良16例[J];北京中醫(yī);1993年05期

4 林鴻;程曉昱;葛嵐;;溫腎益心湯治療慢性充血性心力衰竭32例療效觀察[J];山東中醫(yī)藥大學(xué)學(xué)報(bào);2012年02期

5 丁春;溫腎法在兒科的應(yīng)用[J];福建中醫(yī)藥;1994年03期

6 陳立富;溫腎暖中法治療食后瀉52例[J];浙江中醫(yī)雜志;1995年03期

7 高月平,徐嘉;溫腎疏肝、祛痰化瘀法治療盆腔子宮內(nèi)膜異位癥37例[J];南京中醫(yī)藥大學(xué)學(xué)報(bào);1996年05期

8 王學(xué)平,郭正;溫腎固澀為主治療慢性潰瘍性結(jié)腸炎[J];山東中醫(yī)雜志;1998年12期

9 萬文蓉;程紹魯;張衛(wèi);謝俊杰;葉清景;邱東升;葉姿英;吳秋燕;金海鵬;劉小雪;謝顏穎;;溫腎利氣法針?biāo)幉⒅温宰枞苑渭膊【徑馄趯?duì)患者肺功能影響的臨床研究[J];中華中醫(yī)藥學(xué)刊;2009年01期

10 林蕓;陳麗娜;袁麗萍;王華;杜娟;黃紅英;顏彥;;溫腎育宮湯治療絕經(jīng)后骨質(zhì)疏松癥25例療效觀察[J];河南中醫(yī);2012年09期

相關(guān)會(huì)議論文 前8條

1 李浩勇;梁培育;歐善際;許海波;顏毅;何書明;王聲興;;杞鹿溫腎膠囊治療陰莖勃起功能障礙的療效觀察[A];中華醫(yī)學(xué)會(huì)第八次全國男科學(xué)學(xué)術(shù)會(huì)議論文集[C];2007年

2 李建軍;黃啟輝;陳耀光;羅丹峰;;溫腎強(qiáng)心方治療慢性充血性心力衰竭28例臨床觀察[A];第六次全國中西醫(yī)結(jié)合血瘀證及活血化瘀研究學(xué)術(shù)大會(huì)論文匯編[C];2005年

3 胡曉華;彭煜;;自擬溫腎方治療Ⅱ型糖尿病患者勃起功能障礙36的臨床觀察[A];中華中醫(yī)藥學(xué)會(huì)第十一屆男科學(xué)術(shù)大會(huì)論文集[C];2011年

4 何青松;莫學(xué)德;;溫腎攝精法消除糖尿病尿糖癥體會(huì)[A];著名中醫(yī)學(xué)家吳佩衡學(xué)術(shù)思想研討暨紀(jì)念吳佩衡誕辰120周年（1888-2008）論文集[C];2009年

5 車艷楠;葉輔韜;葉君嵩;;溫腎化瘀法在老年病治療中的應(yīng)用[A];全國中醫(yī)藥防治老年病學(xué)術(shù)交流會(huì)學(xué)術(shù)論文集[C];2011年

6 張學(xué)志;;溫腎解毒話腎衰——通絡(luò)寶應(yīng)用[A];全國第二屆中醫(yī)中西醫(yī)結(jié)合腎臟病臨床進(jìn)展學(xué)術(shù)研討會(huì)論文集[C];2007年

7 李晶;;降脂溫腎活血方治療非酒精性脂肪肝的臨床觀察[A];第二十二屆全國中西醫(yī)結(jié)合消化系統(tǒng)疾病學(xué)術(shù)會(huì)議暨消化疾病診治進(jìn)展學(xué)習(xí)班論文匯編[C];2010年

8 徐e，

本文編號(hào)：2321943