【摘要】：目的探討阿爾茨海默病(AD)證候變化與疾病指標(biāo)認(rèn)知功能變化的相關(guān)性。方法招募阿爾茨海默病患者進(jìn)行證候橫斷面調(diào)查并進(jìn)行24周隨訪研究。年齡40~85歲,分認(rèn)知正常,輕度認(rèn)知損害和癡呆3組。認(rèn)知功能評(píng)估使用簡(jiǎn)易精神狀態(tài)檢查(MMSE)和阿爾茨海默病評(píng)價(jià)量表-認(rèn)知部分(ADAS-cog),以臨床醫(yī)生整體印象加照料者補(bǔ)充的癡呆證候變化總體印象量表(CGICS)作為證候評(píng)價(jià)方法。結(jié)果共383位受試者,對(duì)73例AD患者進(jìn)行隨訪,46例(63%)完成24周隨訪。證候量表的克朗巴赫系數(shù)為0.836,組內(nèi)相關(guān)系數(shù)為0.652(P0.001),具有中等重測(cè)信度(r=0.561,P=0.004)。腎虛和髓減證隨時(shí)間變化,其中腎虛證變化與ADAS-cog變化相關(guān)(r=0.401,P=0.003)。結(jié)論腎虛為代表的證候變化與AD認(rèn)知結(jié)局具有相關(guān)性,腎虛證候分?jǐn)?shù)的變化能反映認(rèn)知功能的變化,在一定程度上可作為AD結(jié)局指標(biāo)。
[Abstract]:Objective to investigate the correlation between the changes of (AD) syndrome and cognitive function of Alzheimer's disease. Methods patients with Alzheimer's disease were recruited for cross-sectional investigation and 24-week follow-up study. The patients aged 40 to 85 years were divided into 3 groups: normal cognition, mild cognitive impairment and dementia. Cognitive function assessment was performed with simple mental state examination (MMSE) and Alzheimer's disease assessment scale (ADAS-cog). General impression scale (CGICS) was used to evaluate the symptoms of dementia. Results A total of 383 subjects were followed up in 73 patients with AD. 46 patients (63%) were followed up for 24 weeks. The Cronbach coefficient of syndrome scale was 0.836, the intra-group correlation coefficient was 0.652 (P0. 001), and had a moderate retest reliability (r = 0. 561, P = 0. 004). The changes of kidney deficiency and medullary depression were correlated with the changes of ADAS-cog (r = 0.401, P < 0. 003). Conclusion the changes of syndromes represented by kidney deficiency are correlated with the cognitive outcome of AD. The change of the score of syndrome of kidney deficiency can reflect the changes of cognitive function and can be used as the outcome index of AD to some extent.
【作者單位】： 北京中醫(yī)藥大學(xué)東直門醫(yī)院腦病三科;北京中醫(yī)藥大學(xué)循證醫(yī)學(xué)中心;中國(guó)中醫(yī)科學(xué)院中醫(yī)臨床基礎(chǔ)醫(yī)學(xué)研究所;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(No.81473518、No.81573824、No.81503625) 高等學(xué)校學(xué)科創(chuàng)新引智計(jì)劃(No.B08006) 首都衛(wèi)生發(fā)展專項(xiàng)(No.2014-1-4191)
【分類號(hào)】：R277.7

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