【摘要】：目的:通過觀察清熱除濕散治療小兒濕疹(濕熱浸淫證)的臨床總有效率,包括靶皮損程度、瘙癢程度及相關(guān)中醫(yī)證候的情況,評價中醫(yī)的內(nèi)外合治法用于臨床實(shí)踐,治療小兒濕疹的臨床療效。方法:選取符合標(biāo)準(zhǔn)的3-9歲90例小兒濕疹患者為研究對象,按就診先后順序,將符合選取條件的病例采用隨機(jī)分組的方法,分為每組30例,即治療組、對照組1和對照組2,共3組。分別給予:中藥外洗加中藥散劑清熱除濕散口服治療、中藥外洗加中成藥龍膽瀉肝顆�？诜委�、單純中藥外洗治療。記錄性別、年齡、病程、主癥(靶皮損程度、瘙癢程度)及兼癥(中醫(yī)證候)等一般情況。三組患者均采取以1周為1個療程,治療2個療程后進(jìn)行療效評價。觀察癥狀積分改善情況,并于治療前和治療后進(jìn)行詳細(xì)記錄。治療2個療程后進(jìn)行療效判斷,采用SPSS20.0軟件處理分析數(shù)據(jù)。結(jié)果:1.治療組、對照組1和對照組2三組患者在性別、年齡、病程等情況的構(gòu)成比比較上均無顯著性差異(P0.05),具有可比性,可以進(jìn)行本次臨床研究。2.主癥積分(靶皮損程度、瘙癢程度):治療2個療程后,三組患兒的靶皮損程度、瘙癢程度積分均有顯著差異(P0.05),表明治療組主癥積分改善優(yōu)于對照組1,對照組1優(yōu)于對照組2。3.兼癥積分(中醫(yī)證候):治療2個療程后,三組患兒中醫(yī)證候積分均有顯著差異(P0.05),表明治療組中醫(yī)證候積分改善優(yōu)于對照組1,對照組1優(yōu)于對照組2。4.此次共完成90例濕疹患兒的臨床觀察,治療組采用清熱解毒止癢外洗方加中藥散劑清熱除濕散沖服治療,在治療2個療程后,治療組總有效率為86.67%,對照組1為70.00%,對照組2為33.33%。三組有效率有差異,表明治療組(中藥外洗加中藥散劑)優(yōu)于對照組1(中藥外洗加中成藥),對照組1優(yōu)于對照組2(單純外洗方治療)。治療組患兒,臨床痊愈 9 例(30%)、顯效 11 例(36.67%)、有效 6 例(20%)、無效 4 例(13.33%),總有效率86.67%;對照組1采用清熱解毒止癢外洗方加中成藥龍膽瀉肝顆粒沖服治療,臨床痊愈3例(10%)、顯效6例(20%)、有效12例(40%)、無效9例(30%),總有效率70%;對照組2單純使用清熱解毒止癢外洗方治療患兒,臨床痊愈1例(3.33%)、顯效0例(0%)、有效9例(30%)、無效20例(66.67%),總有效率33.33%,三組患者療效比較存在顯著性差異(P0.05)。結(jié)論:1.清熱除濕散治療小兒濕疹(濕熱浸淫證)具有顯著療效.2.清熱除濕散治療小兒濕疹(濕熱浸淫證)未見明顯毒副作用,是安全可靠的臨床療法。
[Abstract]:Objective: to observe the total effective rate of clearing away heat and removing dampness powder in treating children eczema, including the degree of target skin damage, the degree of pruritus and related TCM syndromes, and to evaluate the clinical practice of internal and external treatment of TCM. Treatment of eczema in children. Methods: 90 cases of eczema patients aged 3-9 years were selected as the study objects. According to the order of visit, the selected cases were randomly divided into each group (30 cases), that is, treatment group (30 cases). Control group 1 and control group 2, total 3 groups. Respectively: Chinese medicine external washing plus traditional Chinese medicine powder Qingre dehumidification oral treatment, traditional Chinese medicine external washing plus Chinese patent medicine Gentian Xiegan granule oral treatment, simple Chinese medicine external washing treatment. Gender, age, course of disease, main symptoms (target lesions, pruritus) and concurrent symptoms (TCM syndrome) were recorded. All the three groups were treated with 1 week as a course of treatment and evaluated after 2 courses of treatment. Observe the improvement of symptom score and record it before and after treatment. After 2 courses of treatment, the curative effect was judged and the data were analyzed by SPSS20.0 software. The result is 1: 1. Treatment group, control group 1 and control group 2 patients in sex, age, course of disease and other conditions in the composition of comparison no significant difference (P0.05), comparable, can be carried out this clinical study. 2. The main symptom score (target lesion degree, pruritus degree): after two courses of treatment, there were significant differences in the target skin lesion degree and the pruritus degree integral between the three groups (P0.05), which indicated that the improvement of the main symptom score in the treatment group was better than that in the control group (1). Control group 1 was better than control group 2. 3. Syndrome integral (TCM syndrome): after 2 courses of treatment, the three groups of children with TCM syndrome score were significantly different (P0.05), indicating that the treatment group TCM syndrome integral improvement is better than the control group 1, control group 1 is better than the control group 2.4. A total of 90 cases of children with eczema were observed in this study. The treatment group was treated by clearing heat, detoxifying, relieving itching and external washing prescription plus traditional Chinese medicine powder, clearing away heat and removing dampness. After two courses of treatment, the total effective rate of the treatment group was 86.67. Control group 1 was 70.00g and control group 2 33.33. The effective rate of the three groups was different, which indicated that the treatment group (Chinese medicine external washing plus Chinese medicine powder) was better than the control group 1 (traditional Chinese medicine external washing plus Chinese patent medicine), the control group 1 was superior to the control group 2 (simple external washing prescription treatment). In the treatment group, 9 cases (30%) were clinically cured, 11 cases (36.67%) were markedly effective, 6 cases (20%) were effective, 4 cases (13.33%) were ineffective. The total effective rate was 86.67%. The control group (1) was treated with Qingrejiedu antipruritic external washing prescription plus Longdan Xiegan granule, the traditional Chinese patent medicine. 3 cases were cured (10%), 6 cases were effective (20%), 12 cases were effective (40%), 9 cases were ineffective (30%). The total effective rate was 70%. In control group 2, 1 case (3.33%) was cured, 0 cases (0%) had remarkable effect, 9 cases (30%) were effective, 20 cases (66.67%) were ineffective, the total effective rate was 33.33%, and only one case (3.33%) was cured, 9 cases (30%) were effective, 20 cases (66.67%) were ineffective, and the total effective rate was 33.33%. There was significant difference among the three groups (P0.05). Conclusion: 1. Clearing heat and removing dampness powder has remarkable curative effect in treating children eczema (damp heat immersion syndrome). 2. Clearing heat and removing dampness powder is a safe and reliable clinical therapy for the treatment of children eczema.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R275.9

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