【摘要】：目的:用丹萎片和陽性藥物利腦心膠囊做對比,治療老年慢性穩(wěn)定型勞累性心絞痛痰瘀互阻型的患者,評價丹蔞片治療老年慢性穩(wěn)定型勞累性心絞痛痰瘀互阻型的臨床效果及用藥安全性。材料與方法:將2014年12月至2015年12月我院收治的46例老年慢性穩(wěn)定型勞累性心絞痛患者用隨機數表的方法隨機分為丹蔞片治療組(23例)和陽性藥物對照組(23例)。陽性對照組患者在常規(guī)西藥治療基礎上加利腦心膠囊,丹蔞片治療組患者在使用西藥治療的基礎上加用丹萎片進行治療,療程為2個月。分別于治療前后檢測肝功能、腎功能、凝血五項、血常規(guī)、尿常規(guī)、便常規(guī)、心電圖。對比分析兩組患者在改善心絞痛癥狀方面的臨床療效。試驗期間觀察的指標包括,治療前后心絞痛癥狀評分(疼痛程度、發(fā)作次數、持續(xù)時間、硝酸甘油用量)、中醫(yī)癥候評分(包括胸悶、胸痛、心悸、氣短、唇色紫暗、神疲乏力、體胖、多痰、身體困重)、平板運動試驗的Duke評分及西雅圖量心絞痛量表積分。用統(tǒng)計學方法統(tǒng)計處理各觀察指標的統(tǒng)計學意義。結果:在緩解心絞痛癥狀方面,治療組患者治療的總有效率為82.6%,對照組患者治療的總有效率為56.5%,二者相比差異顯著((p=0.004,p0.05),有統(tǒng)計學意義;在中醫(yī)癥候評分比較方面,治療組患者治療的總有效率為91.3%,對照組患者治療的總有效率為21%,二者相比差異顯著((p=0.000,p0.05),有統(tǒng)計學意義;比較兩組治療前后平板運動的Duke評分,治療組治療前后p=0.025,對照組治療前后p=0.397,治療組優(yōu)于對照組;兩組治療后西雅圖心絞痛量表積分比較,p=0.00,p0.05,有統(tǒng)計學意義,治療組優(yōu)于對照組。兩組患者治療均未出現(xiàn)某項安全指標的異常。結論:丹萎片治療老年痰瘀互阻型性慢性穩(wěn)定性心絞痛可取得顯著的臨床療效,有效緩解心絞痛癥狀,改善中醫(yī)臨床癥候,運動耐量情況及西雅圖心絞痛積分情況。而且具有較高的用藥安全性,能有效的改善患者的生活質量。
[Abstract]:Objective: to treat elderly patients with chronic stable angina pectoris with phlegm and blood stasis obstruction by using Danwei tablet and positive drug Liniaoxin capsule. To evaluate the efficacy and safety of Danlou tablet in treating senile chronic stable angina pectoris with phlegm and blood stasis obstruction. Materials and methods: from December 2014 to December 2015, 46 elderly patients with chronic stable angina pectoris were randomly divided into two groups: treatment group (n = 23) and control group (n = 23). The patients in the positive control group were treated with Linaoxin capsule on the basis of routine western medicine, and the patients in the treatment group were treated with Danwei tablet on the basis of western medicine. The course of treatment was 2 months. Liver function, kidney function, coagulation, blood routine, urine routine, stool routine and electrocardiogram were detected before and after treatment. Comparative analysis of the two groups of patients in improving the symptoms of angina pectoris clinical efficacy. The indexes observed during the trial included scores of angina pectoris symptoms before and after treatment (degree of pain, number of episodes, duration, dosage of nitroglycerin), scores of TCM symptoms (including chest tightness, chest pain, palpitations, shortness of breath, dark purple lips, fatigue and fatigue). Body fat, phlegm, body weight), the Duke score of treadmill exercise test and the score of Seattle angina pectoris scale. Statistical method was used to deal with the statistical significance of each observation index. Results: the total effective rate was 82.6 in the treatment group and 56.5 in the control group. The difference between the two groups was significant (p0.004 / p0.05). The total effective rate of the treatment group was 91.3 and that of the control group was 21. The difference between the two groups was significant (P < 0.05). The Duke scores of treadmill exercise before and after treatment were compared between the two groups. Before and after treatment, the treatment group was better than the control group in p0. 025, the control group was better than the control group before and after treatment, and the score of Seattle angina pectoris scale was significantly higher in the two groups after treatment than that in the control group. There was no abnormal safety index in both groups. Conclusion: Danwei tablet can obtain remarkable clinical curative effect in treating senile chronic stable angina pectoris of phlegm and blood stasis mutual obstruction. It can effectively relieve the symptoms of angina pectoris improve the clinical symptoms exercise tolerance and the score of Seattle angina pectoris. Moreover, it has higher drug safety and can effectively improve the quality of life of patients.
【學位授予單位】：遼寧中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259
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本文編號：2290404