蛇床子散加減方治療濕熱下注型外陰上皮非瘤樣病變的臨床療效觀察
發(fā)布時(shí)間：2018-10-23 19:51
【摘要】：目的:觀察蛇床子散加減方熏洗治療濕熱下注型外陰上皮非瘤樣病變的臨床療效,通過(guò)本研究為采用蛇床子散加減方治療外陰上皮非瘤樣病變提供可靠的臨床依據(jù),并評(píng)估蛇床子散加減方治療外陰上皮非瘤樣病變的有效性以及安全性。方法:選取2015年1月至2017年1月于江蘇省中醫(yī)院婦科門診就診,符合納入標(biāo)準(zhǔn)的外陰上皮非瘤樣病變患者30例,予蛇床子散加減方熏洗治療,按照自身治療前后對(duì)照原則,評(píng)價(jià)蛇床子散加減方治療外陰上皮非瘤樣病變的臨床療效。依據(jù)本病的病變特點(diǎn)、中藥外洗的治療特點(diǎn),并結(jié)合導(dǎo)師多年的臨床經(jīng)驗(yàn),采用蛇床子散加減方每天1劑,熏洗外陰,14天為1個(gè)療程。結(jié)果:患者癥狀總積分,治療后與治療前相比,差異有統(tǒng)計(jì)學(xué)意義(P0.05);治療后患者瘙癢、皮膚彈性及顏色、病損范圍積分與治療前相比,均有明顯改善,差異有統(tǒng)計(jì)學(xué)意義(P0.05),且以瘙癢癥狀改善最為顯著;治療后,各癥狀隨著治療時(shí)間的延長(zhǎng),均有明顯改善,其中瘙癢癥狀在第一、二療程改善最明顯;治療后皮膚彈性及顏色均在第三、四療程改善最明顯;治療后病損面積改善在最后兩個(gè)療程改善最明顯;不同病程患者之間的癥狀改善情況比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);中度患者治療后癥狀改善程度優(yōu)于輕度患者(P0.05);6個(gè)療程后,30例患者中,痊愈7例,痊愈率23.33%;顯效15例,顯效率50.00%;好轉(zhuǎn)6例,好轉(zhuǎn)率20.00%;無(wú)效2例,無(wú)效率6.67%,無(wú)不良反應(yīng)發(fā)生,總有效率為93.33%。結(jié)論:中藥熏洗治療外陰上皮非瘤樣病變安全無(wú)創(chuàng)可靠,經(jīng)過(guò)臨床病例觀察,蛇床子散加減方治療外陰上皮非瘤樣病變有很好的臨床療效,無(wú)不良反應(yīng)及過(guò)敏反應(yīng)發(fā)生,值得進(jìn)一步推廣應(yīng)用于臨床。
[Abstract]:Objective: to observe the clinical effect of Cnidium powder plus subtractive prescription fumigation in the treatment of non-tumor-like lesions of vulvar epithelium, and to provide a reliable clinical basis for the treatment of non-tumor-like lesions of vulvar epithelium by using Cnidium powder plus subtraction prescription. To evaluate the efficacy and safety of Cnidium Powder plus or minus prescription in the treatment of vulvar epithelial non-tumor-like lesions. Methods: from January 2015 to January 2017, 30 cases of vulvar epithelial nontumor-like lesions were selected from gynecological outpatient clinic of Jiangsu Provincial Hospital of traditional Chinese Medicine, treated by fumigation and washing of Cnidium Powder plus or minus prescription, and according to the principle of self-control before and after treatment. To evaluate the clinical effect of Cnidium Powder plus subtraction in the treatment of non-tumor-like lesions of vulvar epithelium. According to the pathological characteristics of the disease, the characteristics of external washing of traditional Chinese medicine and the clinical experience of teachers for many years, one dose of the prescription of adding and decreasing the powder of Cnidium cnidii was used to fumigate and wash the vulva for 14 days as a course of treatment. Results: the total score of symptoms after treatment was significantly higher than that before treatment (P0.05), and the patients' pruritus, skin elasticity and color, and the score of lesion range were significantly improved after treatment. The difference was statistically significant (P0.05), and the most significant improvement was the pruritus symptoms; after treatment, the symptoms were obviously improved with the prolongation of treatment time, among which, the pruritus symptoms were improved most obviously in the first and second courses of treatment. After treatment, the skin elasticity and color were significantly improved in the third and fourth courses of treatment; the improvement of lesion area was most obvious in the last two courses of treatment; the improvement of symptoms among patients with different course of disease was compared. The difference was not statistically significant (P0.05); the degree of improvement of symptoms after treatment in moderate patients was better than that in mild patients (P0.05); after 6 courses of treatment, 7 cases were cured, and the cure rate was 23.33%; 15 cases were markedly effective, the effective rate was 50.005%; 6 cases improved, the improvement rate was 20.00%; 2 cases were ineffective. The total effective rate was 93.33. Conclusion: fumigation and washing of traditional Chinese medicine is safe and noninvasive in the treatment of nontumor-like lesions of vulvar epithelium. The clinical observation shows that Cnidium nididii Powder plus subtractive prescription has a good clinical effect in the treatment of non-tumor-like lesions of vulvar epithelium without adverse reactions and allergic reactions. It is worth further popularizing and applying in clinic.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R271.9
[Abstract]:Objective: to observe the clinical effect of Cnidium powder plus subtractive prescription fumigation in the treatment of non-tumor-like lesions of vulvar epithelium, and to provide a reliable clinical basis for the treatment of non-tumor-like lesions of vulvar epithelium by using Cnidium powder plus subtraction prescription. To evaluate the efficacy and safety of Cnidium Powder plus or minus prescription in the treatment of vulvar epithelial non-tumor-like lesions. Methods: from January 2015 to January 2017, 30 cases of vulvar epithelial nontumor-like lesions were selected from gynecological outpatient clinic of Jiangsu Provincial Hospital of traditional Chinese Medicine, treated by fumigation and washing of Cnidium Powder plus or minus prescription, and according to the principle of self-control before and after treatment. To evaluate the clinical effect of Cnidium Powder plus subtraction in the treatment of non-tumor-like lesions of vulvar epithelium. According to the pathological characteristics of the disease, the characteristics of external washing of traditional Chinese medicine and the clinical experience of teachers for many years, one dose of the prescription of adding and decreasing the powder of Cnidium cnidii was used to fumigate and wash the vulva for 14 days as a course of treatment. Results: the total score of symptoms after treatment was significantly higher than that before treatment (P0.05), and the patients' pruritus, skin elasticity and color, and the score of lesion range were significantly improved after treatment. The difference was statistically significant (P0.05), and the most significant improvement was the pruritus symptoms; after treatment, the symptoms were obviously improved with the prolongation of treatment time, among which, the pruritus symptoms were improved most obviously in the first and second courses of treatment. After treatment, the skin elasticity and color were significantly improved in the third and fourth courses of treatment; the improvement of lesion area was most obvious in the last two courses of treatment; the improvement of symptoms among patients with different course of disease was compared. The difference was not statistically significant (P0.05); the degree of improvement of symptoms after treatment in moderate patients was better than that in mild patients (P0.05); after 6 courses of treatment, 7 cases were cured, and the cure rate was 23.33%; 15 cases were markedly effective, the effective rate was 50.005%; 6 cases improved, the improvement rate was 20.00%; 2 cases were ineffective. The total effective rate was 93.33. Conclusion: fumigation and washing of traditional Chinese medicine is safe and noninvasive in the treatment of nontumor-like lesions of vulvar epithelium. The clinical observation shows that Cnidium nididii Powder plus subtractive prescription has a good clinical effect in the treatment of non-tumor-like lesions of vulvar epithelium without adverse reactions and allergic reactions. It is worth further popularizing and applying in clinic.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R271.9
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