【摘要】：目的:觀察豁痰通痹湯對(duì)冠心病PCI術(shù)后痰瘀痹阻證患者血脂水平、心絞痛癥狀、中醫(yī)癥候積分的影響,評(píng)價(jià)豁痰通痹湯的臨床療效。方法:根據(jù)標(biāo)準(zhǔn)入選冠心病PCI術(shù)后痰瘀痹阻證患者共60例,隨機(jī)分為對(duì)照組、治療組各30例。對(duì)照組給予西醫(yī)常規(guī)治療,治療組則為西醫(yī)常規(guī)治療+豁痰通痹湯,療程均為3個(gè)月。觀察治療前后兩組患者血脂水平、心絞痛癥狀以及中醫(yī)證候積分的變化情況。結(jié)果:(1)血脂指標(biāo):經(jīng)治療,兩組病例的血脂水平(TG、TC、HDL-C、LDL-C)均明顯改善(治療組:1.73±0.74,4.38±0.94,1.23±0.31,3.11±0.76vs0.96±0.29,2.86±0.51,1.53±0.44,1.36±0.34;對(duì)照組:1.88±0.82,4.67±0.86,1.18±0.31,3.11±0.72vs1.32±0.66,3.40±0.82,1.46±0.53,1.62±0.42),與治療前相比有極顯著統(tǒng)計(jì)學(xué)差異(P0.01);治療后,治療組病例 TC(2.86±0.51vs3.40±0.82)、LDL-C(1.36±0.34vs1.62±0.42)療效顯著優(yōu)于對(duì)照組(P0.01),TG(0.96±0.29vs1.32±0.66)療效較對(duì)照組好(P0.05),而HDL-C(1.53±0.44vs1.62±0.42)療效較對(duì)照組無(wú)顯著差異。(2)心絞痛療效:治療組和對(duì)照組均能改善患者心絞痛癥狀,治療組的總有效率為90%,對(duì)照組的總有效率為83.3%,治療組稍優(yōu)于對(duì)照組,但無(wú)統(tǒng)計(jì)學(xué)差異(P0.05)。(3)中醫(yī)癥候積分:兩組患者在治療前后中醫(yī)癥候積分(治療組:25.87±3.17vs9.93± 1.80,對(duì)照組:25.57±2.58vs 13.03±2.36)具有極顯著統(tǒng)計(jì)學(xué)差異(P0.01);治療組積分(9.93±1.80vs13.03±2.36)改善情況優(yōu)于對(duì)照組,具有統(tǒng)計(jì)學(xué)意義(P0.05);治療組在改善胸悶不適(1.87±1.04vs 2.53±1.04)和嘔惡痰涎(0.87±1.01vs1.60±1.10)的積分方面優(yōu)于對(duì)照組(P0.05)。(4)安全性指標(biāo):治療期間兩組患者血常規(guī)及肝腎功能檢查均未見明顯異常改變;兩組病例均無(wú)肌肉酸痛、過(guò)敏等不良反應(yīng);兩組患者均無(wú)致命性出血、支架內(nèi)血栓等事件發(fā)生。結(jié)論:在常規(guī)西醫(yī)治療的基礎(chǔ)上加用豁痰通痹湯,可進(jìn)一步改善冠心病PCI術(shù)后患者血脂水平、改善中醫(yī)癥候積分,其有效性及安全性值得肯定。
[Abstract]:Objective: to observe the effect of Huatan Tongbi decoction on blood lipid level, angina pectoris symptom and TCM symptom score in patients with phlegm stasis obstruction syndrome after coronary heart disease (PCI), and to evaluate the clinical curative effect of Huatan Tongbi decoction. Methods: according to the standard, 60 patients with phlegm and stasis obstruction after PCI were randomly divided into control group (n = 30) and treatment group (n = 30). The control group was treated with routine western medicine, the treatment group was treated with traditional western medicine, the course of treatment was 3 months. The changes of blood lipid level, angina pectoris symptom and TCM syndromes were observed before and after treatment. 緇撴灉:(1)琛，

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