【摘要】：目的:通過對化濁安神方治療原發(fā)性失眠痰熱擾心證的臨床觀察,為中醫(yī)藥治療此類疾病提供新思路,并從血濁理論的角度對該病病因病機(jī)以及治法方藥進(jìn)行探討。方法:選取來自山東中醫(yī)藥大學(xué)附屬醫(yī)院腦病科門診,符合篩選條件的原發(fā)性失眠痰熱擾心證的患者60例,隨機(jī)分為兩組,每組30例。分別標(biāo)記為試驗(yàn)組和對照組。兩組在進(jìn)行臨床觀察前在性別、年齡、失眠嚴(yán)重程度、匹茲堡睡眠質(zhì)量指數(shù)、中醫(yī)證候評分上均無顯著性差異(P0.05)。試驗(yàn)組予以化濁安神方,對照組予以黃連溫膽湯方,必要時予以西藥暫時治療。服用3周藥物后,停藥1周后,分別觀察其治療前后失眠改善程度、中醫(yī)證候評分、匹茲堡睡眠質(zhì)量指數(shù)的變化。結(jié)果:服用3周藥物后,停藥1周觀察:1.試驗(yàn)組和對照組患者中醫(yī)證候均得到改善,且試驗(yàn)組較對照組明顯占優(yōu)勢(P0.01);2.試驗(yàn)組和對照組患者主觀睡眠時間均有所延長,試驗(yàn)組主觀入睡時間延長優(yōu)于對照組(P0.01);3.試驗(yàn)組和對照組患者入睡所需時間均有所縮短,試驗(yàn)組入睡所需時間明顯少于對照組(P0.01);4.試驗(yàn)組和對照組患者臨床癥狀均得到改善,且試驗(yàn)組臨床癥狀改善情況明顯優(yōu)于對照組(P0.01)。5.在試驗(yàn)組與對照組服用藥物過程中,兩組患者均未出現(xiàn)明顯重大不良事件,安全性指標(biāo)檢查未出現(xiàn)異常。結(jié)論:化濁安神方對改善原發(fā)性失眠痰熱擾心證有較好的效果,可改善患者中醫(yī)證候、減少患者入睡時間、增加主觀睡眠時間、提升睡眠質(zhì)量,且無不良反應(yīng)。
[Abstract]:Objective: through clinical observation of Huazhuo Anshen prescription in treating primary insomnia and phlegm heat disturbing heart syndrome, to provide a new way for TCM to treat this kind of disease, and to discuss the etiology and pathogenesis of this disease and the prescription of treatment from the point of view of blood turbid theory. Methods: sixty patients with primary insomnia, phlegm and heat disturbance were selected from the Department of Encephalopathy, affiliated Hospital of Shandong University of traditional Chinese Medicine, and were randomly divided into two groups, 30 cases in each group. They were labeled as experimental group and control group respectively. There was no significant difference in sex age insomnia severity Pittsburgh sleep quality index and TCM syndrome score between the two groups before clinical observation (P0.05). The experimental group was treated with Huazhuo Anshen recipe, the control group with Huanglian Wendan decoction, and the control group with temporary treatment with western medicine. After taking drugs for 3 weeks and stopping for 1 week, the improvement degree of insomnia, TCM syndrome score and Pittsburgh sleep quality index were observed before and after treatment. Results: after 3 weeks treatment, 1 week observation: 1. Experimental group and control group patients with TCM syndrome were improved, and the test group was significantly superior to the control group (P0.01); 2. The subjective sleep time of the test group and the control group were prolonged, and the subjective sleep time of the test group was longer than that of the control group (P0.01). The time required to fall asleep in both the experimental group and the control group was shorter than that in the control group (P0.01). The clinical symptoms of both the experimental group and the control group were improved, and the improvement of the clinical symptoms in the experimental group was significantly better than that in the control group (P0.01). There were no significant adverse events and no abnormal safety indexes in both groups. Conclusion: Huazhuo Anshen prescription has good effect on improving the syndrome of phlegm and heat disturbing heart in patients with primary insomnia. It can improve the syndrome of TCM, reduce the time of falling asleep, increase the time of subjective sleep, improve the quality of sleep, and have no adverse reactions.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R256.23

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 唐晴;王蓉;席凡捷;張亭亭;高茹;蔣運(yùn)蘭;;失眠的中醫(yī)研究進(jìn)展[J];中國療養(yǎng)醫(yī)學(xué);2015年04期

2 王愛潔;隋在云;劉瑾;李曉晶;;中藥川芎的藥代動力學(xué)研究新進(jìn)展[J];遼寧中醫(yī)藥大學(xué)學(xué)報(bào);2015年04期

3 孔平;;牡丹皮的化學(xué)成分分析研究概況[J];化工管理;2015年06期

4 劉廣學(xué);李敬林;;李敬林辨證治療不寐證經(jīng)驗(yàn)[J];山東中醫(yī)雜志;2014年04期

5 杜輝;李桂俠;呂學(xué)玉;汪衛(wèi)東;;失眠的心理生理發(fā)病機(jī)制探討[J];世界中醫(yī)藥;2013年05期

6 李艷蓉;吳紹從;;不寐從五臟分型論治[J];中醫(yī)臨床研究;2013年09期

7 黃義松;;劉泰辨證分期治療不寐[J];實(shí)用中醫(yī)內(nèi)科雜志;2013年03期

8 莊慧魁;;腦血辨證對不寐病機(jī)的認(rèn)識[J];中國中醫(yī)藥現(xiàn)代遠(yuǎn)程教育;2012年10期

9 范秀芳;梁政亭;張星平;;中醫(yī)不寐五神分型與四診分型在五臟定位上的一致性比較[J];中醫(yī)藥學(xué)報(bào);2011年06期

10 趙江麗;趙婷;張敏;仰榴青;吳向陽;白石琦;馮偉偉;李鵬霄;;半夏不同溶劑提取物鎮(zhèn)靜催眠活性比較[J];安徽農(nóng)業(yè)科學(xué);2011年35期

相關(guān)會議論文 前1條

1 趙忠新;彭華;;主觀性失眠的研究進(jìn)展[A];第2屆中國睡眠醫(yī)學(xué)論壇論文匯編[C];2007年

相關(guān)重要報(bào)紙文章 前1條

1 衣曉峰;;不寐癥辨證論治三要點(diǎn)[N];中國中醫(yī)藥報(bào);2010年

相關(guān)碩士學(xué)位論文 前1條

1 王雀良;慢性心理生理性失眠患者睡眠紡錘波特征的對照研究[D];暨南大學(xué);2011年

，

本文編號：2273903