【摘要】：目的觀察大柴胡湯加味對急危重癥患者應(yīng)激狀態(tài)下腸道屏障功能的影響。方法將102例急危重癥患者隨機(jī)分為對照組和觀察組各51例,對照組給予常規(guī)腸胃復(fù)蘇治療,觀察組在對照組治療基礎(chǔ)上給予大柴胡湯加味胃管灌注,早晚各1次,直至排氣恢復(fù)。觀察2組治療前及治療7 d后腸功能障礙評分及血二胺氧化酶(DAO)、腸脂肪酸結(jié)合蛋白(IFABP)、尿乳果糖/甘露醇(L/M)水平變化情況,統(tǒng)計(jì)2組腹腔器官感染及腸道細(xì)菌全身感染發(fā)生率。結(jié)果治療7 d后,2組腸功能障礙評分≤1分比例均明顯高于治療前(P均0.05),而≥3分比例則明顯低于治療前(P均0.05),且觀察組≤1分比例明顯高于對照組(P0.05),≥3分比例明顯低于對照組(P0.05);2組DAO均明顯升高(P均0.05),IFABP、L/M均明顯降低(P均0.05),且觀察組各指標(biāo)改善情況明顯優(yōu)于對照組(P均0.05)。觀察組腹腔器官感染及腸道細(xì)菌全身感染發(fā)生率均明顯低于對照組(P均0.05)。結(jié)論大柴胡湯加味治療急危重癥患者應(yīng)激狀態(tài)下腸道屏障功能可明顯改善腸道功能障礙,減輕腸道炎性反應(yīng),并有效降低感染發(fā)生率,可在臨床推廣應(yīng)用。
[Abstract]:Objective to observe the effect of Dachaihu decoction on intestinal barrier function in acute and critical patients. Methods 102 patients were randomly divided into control group (n = 51) and observation group (n = 51). The control group was treated with routine gastrointestinal resuscitation. The observation group was treated with Dachaihu decoction plus modified gastric tube on the basis of the treatment in the control group, one time in the morning and evening. Until the exhaust recovers. The scores of intestinal dysfunction and the levels of serum diamine oxidase (DAO),) intestinal fatty acid binding protein (IFABP), lactulose / mannitol (L / M), were observed before and 7 days after treatment in the two groups. The incidence of celiac organ infection and enterobacterial bacterial systemic infection were counted. Results after 7 days of treatment, the proportion of intestinal dysfunction score 鈮，

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