【摘要】：目的:觀察辛通顆粒治療風(fēng)熱犯肺型小兒腺樣體肥大的臨床療效,評(píng)估該方的有效性。同時(shí)觀察患兒服藥過程中是否出現(xiàn)不良反應(yīng),初步評(píng)估該方藥物的安全性。方法:選取符合納入標(biāo)準(zhǔn)的病患72例,以隨機(jī)單盲法平均分為觀察組和對(duì)照組,觀察組口服辛通顆粒,對(duì)照組外用糠酸莫米松鼻噴霧劑,兩組均連續(xù)治療15天,綜合評(píng)估兩組患兒治療前后癥狀、體征及輔助檢查等的變化,統(tǒng)計(jì)分析,評(píng)估臨床療效。結(jié)果:選取的72例患者中,有12例(被剔除和脫落)未被納入最終研究,對(duì)試驗(yàn)前兩組患者的各項(xiàng)資料經(jīng)對(duì)比后,差異無(wú)統(tǒng)計(jì)學(xué)意義,具有可比性,可以開始臨床研究。(1)連續(xù)15天治療后兩組患兒的證候積分均低于治療前,前后積分對(duì)比,差別均有統(tǒng)計(jì)學(xué)意義(P0.05),提示觀察組、對(duì)照組的治療均為有效;(2)觀察組和對(duì)照組的總有效率分別為90%、70%,差別有統(tǒng)計(jì)學(xué)意義(P0.05),提示觀察組的總有效率優(yōu)于對(duì)照組;(3)治療后觀察組證候總積分、主要積分、次要積分均低于對(duì)照組,差別有統(tǒng)計(jì)學(xué)意義(P0.05),提示在改善總體證候、主要證候、次要證候方面,觀察組的療效優(yōu)于對(duì)照組;(4)兩組患兒治療后,打鼾、張口呼吸、鼻塞、咽部異物感、咽后壁淋巴濾泡增生、大便干結(jié)單項(xiàng)積分差別有統(tǒng)計(jì)學(xué)意義(P0.05),提示觀察組在改善打鼾、張口呼吸、鼻塞、咽部異物感、咽后壁淋巴濾泡增生、大便干結(jié)方面的療效優(yōu)于對(duì)照組;(5)兩組患兒治療后,扁桃體腫大單項(xiàng)積分差別無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),提示在改善扁桃體腫大方面兩組療效相當(dāng);(6)兩組患兒治療期間均未出現(xiàn)不良反應(yīng)。結(jié)論:通過對(duì)辛通顆粒治療小兒腺樣體肥大風(fēng)熱犯肺型的臨床研究,表明該方治療小兒腺樣體肥大風(fēng)熱犯肺型療效肯定,且未發(fā)現(xiàn)不良反應(yīng),口服安全有效,值得進(jìn)一步臨床推廣應(yīng)用。
[Abstract]:Aim: to observe the clinical effect of Xintong granule on adenoid hypertrophy in children with wind-heat invasion of lung type and to evaluate the effectiveness of Xintong granule. At the same time, the adverse reactions were observed and the safety of the prescription was preliminarily evaluated. Methods: a total of 72 patients who met the inclusion criteria were randomly divided into two groups: the observation group and the control group. The observation group was treated with xintong granule and the control group was treated with momethasone furoate nasal spray for 15 days. The changes of symptoms, signs and adjuvant examinations before and after treatment were comprehensively evaluated, and the clinical efficacy was evaluated by statistical analysis. Results: of the 72 selected patients, 12 (excluded and dropped) were not included in the final study. After comparing the data of the two groups before the trial, the difference was not statistically significant and comparable. Clinical study can be started. (1) after 15 consecutive days of treatment, the syndrome scores of the two groups were lower than those before treatment, the difference between the scores before and after treatment was statistically significant (P0.05), indicating that the observation group, The treatment of the control group is effective; (2) the total effective rate of the observation group and the control group is 90%, the difference is statistically significant (P0.05), indicating that the total effective rate of the observation group is better than that of the control group; (3) the total syndrome integral, the main integral of the observation group after treatment. Secondary scores were lower than the control group, the difference was statistically significant (P0.05), suggesting that in improving the overall syndrome, main syndrome, secondary syndrome, the observation group is better than the control group; (4) after treatment, the two groups of children snoring, open mouth breathing, nasal obstruction, Foreign body sensation in pharynx, hyperplasia of lymphoid follicle in posterior wall of pharynx, single score of dry knot of stool were significantly different (P0.05), indicating that the observation group was improving snoring, opening mouth breathing, nasal obstruction, feeling of foreign body in pharynx, hyperplasia of lymphoid follicle in posterior wall of pharynx, The curative effect of stool dry knot was better than that of the control group; (5) after treatment, there was no significant difference in the single score of tonsil enlargement between the two groups (P0.05), indicating that the two groups had the same curative effect in improving tonsillar swelling; (6) there were no adverse reactions in both groups during the treatment period. Conclusion: the clinical study on the treatment of children adenoid hypertrophy with wind-heat invading lung type by Xintong granule shows that this prescription has definite curative effect on children with adenoid hypertrophy and wind-heat invading lung type, and no adverse reaction has been found, and oral administration is safe and effective. It is worthy of further clinical application.
【學(xué)位授予單位】：云南中醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R276.1

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