【摘要】：目的:本課題應(yīng)用十全大補(bǔ)湯配合艾灸(膈俞穴、三陰交穴)療法對(duì)NSCLC化療后骨髓抑制(脾腎虧虛型)進(jìn)行臨床觀察,以明確其療效,治療患者化療后引起的骨髓抑制(脾腎虧虛型),延長(zhǎng)患者生存期及改善其生活質(zhì)量。方法:本課題將選取2015年3月——2015年12月長(zhǎng)春中醫(yī)藥大學(xué)附屬醫(yī)院腫瘤血液科住院NSCLC化療后I度骨髓抑制患者60例,隨機(jī)分成兩組,治療組及對(duì)照組均為30例,采用平行對(duì)照的試驗(yàn)方法。治療組用十全大補(bǔ)湯合并艾灸(膈俞穴、三陰交穴)療法,對(duì)照組單純使用十全大補(bǔ)湯治療。治療組:用十全大補(bǔ)湯水煎劑,每日一劑,早晚服用。艾灸療法采用艾柱灸膈俞、三陰交兩穴,每次每穴3壯,每天一次。上法配合使用15天,并分別于治療前1天,治療第7天,治療第15天測(cè)定血常規(guī)以監(jiān)測(cè)骨髓抑制程度。對(duì)照組:用十全大補(bǔ)湯水煎劑,每日一劑,早晚服用。療程15天,并分別于治療前1天,治療第7天,治療第15天測(cè)定血常規(guī)以監(jiān)測(cè)骨髓抑制程度。在治療前后,同時(shí)對(duì)中醫(yī)臨床癥狀、KPS評(píng)分狀況進(jìn)行比較。經(jīng)相關(guān)統(tǒng)計(jì)學(xué)軟件(spss.16.0)分析,對(duì)其療效做出客觀的評(píng)價(jià)。結(jié)果:本研究實(shí)際入組病例為60例。血象變化:治療組外周血象中白細(xì)胞及中性粒細(xì)胞計(jì)數(shù)指標(biāo)均明顯優(yōu)于對(duì)照組。中醫(yī)癥狀改善情況:治療組總有效率為86.67%;對(duì)照組總有效率為66.67%,治療組在中醫(yī)癥狀改善上有明顯提高。生活質(zhì)量改善情況:根據(jù)治療后KPS評(píng)分結(jié)果,治療組在改善人體功能狀態(tài)方面療效更好。結(jié)論:1、通過(guò)應(yīng)用十全大補(bǔ)湯配合艾灸(膈俞穴、三陰交穴)療法的治療,可以明顯改善NSCLC化療后I度骨髓抑制患者的血象,并改善臨床癥狀。2、藥、灸合用的療效優(yōu)勢(shì)不僅表現(xiàn)為化療后骨髓抑制的改善,還表現(xiàn)為患者生活質(zhì)量的提高及生存期的延長(zhǎng)等。此外,此療法療效顯著,具有深遠(yuǎn)的研究?jī)r(jià)值及開(kāi)發(fā)前景。
[Abstract]:Objective: to observe the effect of Shiquan Dabu decoction combined with moxibustion (Geshu point, Sanyinjiao point) on bone marrow depression (deficiency of spleen and kidney) after NSCLC chemotherapy. The bone marrow depression (deficiency of spleen and kidney) caused by chemotherapy can prolong the survival time and improve the quality of life of the patients. Methods: from March 2015 to December 2015, 60 patients with degree I bone marrow suppression after NSCLC chemotherapy were randomly divided into two groups: 30 patients in the treatment group and 30 in the control group, in the department of tumor hematology, affiliated Hospital of Changchun University of traditional Chinese Medicine, from March 2015 to December 2015. A parallel controlled test was used. The treatment group was treated with Shiquan Da Bu decoction combined with moxibustion (Geshu point, Sanyinjiao point), while the control group was treated with Shiquan Da Bu decoction. The treatment group: take the decoction, one dose daily, morning and evening. Moxibustion therapy is used to moxibustion Geshu, Sanyinjiao two points, each point 3 strong, once a day. Combined therapy was used for 15 days, and blood routine was measured on day 15 before treatment and on day 7 to monitor the degree of bone marrow depression. The control group: take the decoction once a day and take it in the morning and evening. The course of treatment was 15 days, and the blood routine was measured on day 15, 1 day before treatment, 7 days before treatment and 15 days after treatment to monitor the degree of bone marrow suppression. At the same time, the KPS scores of TCM clinical symptoms were compared before and after treatment. The curative effect was evaluated objectively by correlation statistical software (spss.16.0). Results: there were 60 cases in this study. The changes of hematology: the leukocytes and neutrophils in peripheral blood of the treatment group were better than that of the control group. The improvement of TCM symptoms: the total effective rate of the treatment group was 86.67 and the total effective rate of the control group was 66.67. The improvement of the TCM symptoms in the treatment group was obviously improved. The improvement of quality of life: according to the KPS score after treatment, the treatment group has better effect in improving the function of human body. Conclusion: by applying Shiquan Da Bu Tang and moxibustion therapy (Geshu point, Sanyinjiao point), the hematology of patients with degree I bone marrow depression after NSCLC chemotherapy can be obviously improved, and the clinical symptoms. The advantages of combined moxibustion were not only the improvement of bone marrow suppression after chemotherapy, but also the improvement of patients' quality of life and the prolongation of survival time. In addition, the therapeutic effect is significant, and has a profound research value and development prospects.
【學(xué)位授予單位】：長(zhǎng)春中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R273

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