【摘要】：該研究旨在闡明維藥阿里紅的藥效物質(zhì)基礎(chǔ)。采用各種現(xiàn)代色譜手段(MCI,ODS,硅膠等柱色譜以及半制備高效液相色譜)從阿里紅甲醇提取物中分離得到2個(gè)新的羊毛甾烷型三萜酸成分,通過一維,二維核磁共振、高分辨質(zhì)譜等波譜手段鑒定其結(jié)構(gòu)為12β,15α-dihydroxy-24-methyl-3,23-dioxo-lanosta-7,9(11)-dien-26-oic acid(1),3α,12β-dihydroxy-24-methyl-7,23-dioxo-lanosta-8-en-26-oic acid(2)。體外抗炎和細(xì)胞毒活性測(cè)試顯示,化合物1和2均未表現(xiàn)出抑制LPS誘導(dǎo)RAW264.7細(xì)胞NO的產(chǎn)生,以及抑制肝癌細(xì)胞HepG2生長的活性。
[Abstract]:The purpose of this study is to elucidate the pharmacodynamic basis of the Uygur drug Ali Hong. Two new lanosterol triterpene acids were isolated from the methanol extract of Ali Hong by various modern chromatographic methods (MCI, ODS, silica gel and semi-preparative high performance liquid chromatography). The compounds were identified by one-dimensional, two-dimensional nuclear magnetic resonance and high resolution mass spectrometry. Its structure was 12beta, 15a-dihydroxy-24-methyl-3, 23-dioxo-lanosta-7, 9 (11) -dien-26-oic acid (1), 3a, 12beta-dihydroxy-24-methyl-7, 23-dioxo-lanosta-8-en-26-oic acid (2). In vitro anti-inflammatory and cytotoxicity tests showed that compounds 1 and 2 did not inhibit LPS-induced NO production in RAW264.7 cells and inhibited NO production in liver cancer cells. The activity of pG2 growth.
【作者單位】： 中國科學(xué)院干旱區(qū)植物資源化學(xué)重點(diǎn)實(shí)驗(yàn)室新疆特有藥用資源利用重點(diǎn)實(shí)驗(yàn)室中國科學(xué)院新疆理化技術(shù)研究所;中國科學(xué)院大學(xué);
【基金】：千人計(jì)劃新疆項(xiàng)目
【分類號(hào)】：R29

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