【摘要】：目的評價中藥治療廣泛耐藥肺結(jié)核(XDR-TB)患者的臨床療效。方法選取2013年11月至2015年11月來自6家結(jié)核病定點診療單位的XDR-TB患者80例,將所有患者隨機分為4組,每組20例。益肺通絡(luò)方組給予益肺通絡(luò)方顆粒劑沖服,每次18.54 g,每日2次;抗癆清肺方組給予抗癆清肺方顆粒劑沖服每次15.08 g,每日2次;益肺通絡(luò)方合并霧化組在益肺通絡(luò)方組治療基礎(chǔ)上聯(lián)合霧化益肺精白方安瓿裝水劑,每次10 ml,每次5~10 min;抗癆清肺方合并霧化組在抗癆清肺方治療基礎(chǔ)上聯(lián)合霧化益肺精白方安瓿裝水劑,每次10 ml,每次5~10 min。各組均連續(xù)治療12個月。觀察并比較各組患者治療后的治療轉(zhuǎn)歸情況、病灶吸收程度及中醫(yī)證候療效。結(jié)果治療結(jié)束后完全符合研究方案的患者共計61例,其治療成功率為23.0%,總死亡率為6.5%,肺部病灶吸收率為37.7%,中醫(yī)證候總有效率達63.9%,以上各指標各組間比較差異均無統(tǒng)計學意義(P0.05)。61例患者在治療過程中均無藥物不良反應發(fā)生。結(jié)論中藥治療XDR-TB可有效促進痰菌陰轉(zhuǎn)及肺部病灶吸收,有效改善患者臨床癥狀。
[Abstract]:Objective to evaluate the clinical efficacy of traditional Chinese medicine (TCM) in the treatment of extensively resistant pulmonary tuberculosis (XDR-TB). Methods from November 2013 to November 2015, 80 patients with XDR-TB were randomly divided into 4 groups, 20 patients in each group. Yifei Tongluo decoction group was given Yifei Tongluo granule, 18.54 g per day, 2 times a day, the anti-tuberculosis Qingfei prescription group was given anti-tuberculosis Qingfei granule 15.08 g, twice a day. Yifei Tongluo recipe combined with atomization group combined with atomization of Baifang ampoule containing water on the basis of treatment of Yifei Tongluo recipe group, 10 ml, 10 min; anti-tuberculosis Qingfei prescription combined with atomization group combined with anti-tuberculosis Qingfei prescription on the basis of treatment of anti-tuberculosis Qingfei prescription combined with atomization of Yifei essence white square ampoule containing water, 10 ml, each time 5 minutes 10 min. All groups were treated continuously for 12 months. To observe and compare the therapeutic outcome, the degree of focus absorption and the curative effect of TCM syndrome. Results A total of 61 patients with complete compliance with the study program after treatment were included. The successful rate of treatment was 23.0, the total mortality was 6.5, the absorption rate of pulmonary focus was 37.7 and the total effective rate of TCM syndromes was 63.9. There was no significant difference among the above indexes (P0.05) .61 patients had no adverse drug reactions in the course of treatment. Conclusion Chinese medicine can effectively promote sputum negative transformation and pulmonary focus absorption, and improve the clinical symptoms of patients with XDR-TB.
【作者單位】： 長沙市中心醫(yī)院;武漢市醫(yī)療救治中心;麗水市中醫(yī)院;福建省福州肺科醫(yī)院;郴州市第二人民醫(yī)院;衡陽市第三人民醫(yī)院;
【基金】：國家衛(wèi)生和計劃生育委員會中醫(yī)藥防治重大傳染病項目(2013ZX10005004)
【分類號】：R259

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