【摘要】：目的:對(duì)小柴胡湯加減治療慢傳輸型便秘(腸道氣滯型)進(jìn)行臨床療效分析,并探討其機(jī)理。資料與方法:研究資料均選自于2015年1月至2016年6月就診于遼寧中醫(yī)藥大學(xué)附屬第三醫(yī)院(遼寧省肛腸醫(yī)院)確診為慢傳輸型便秘(腸道氣滯型),并符合納入標(biāo)準(zhǔn)的門診患者,共64例。按隨機(jī)數(shù)字表法將所選患者隨機(jī)分為治療組(小柴胡湯加減組)33例,對(duì)照組(木香檳榔丸組)31例。治療組予以小柴胡湯加減治療,水煎服,日3次,100ml/次;對(duì)照組予以木香檳榔丸治療,口服,日3次,1袋/次。兩組均以2周為1療程,治療2個(gè)療程后對(duì)研究結(jié)果進(jìn)行統(tǒng)計(jì)。觀察兩組治療前后焦慮、抑郁評(píng)分,結(jié)腸傳輸試驗(yàn)72小時(shí)標(biāo)記物排出粒數(shù),便秘癥狀總積分及臨床療效、安全性等。用SPSS17.0統(tǒng)計(jì)軟件對(duì)臨床數(shù)據(jù)進(jìn)行統(tǒng)計(jì)分析并對(duì)結(jié)果加以分析評(píng)價(jià)。結(jié)果:1.在焦慮、抑郁評(píng)分方面,兩組均較治療前有明顯降低(P0.05),且治療組降低幅度明顯優(yōu)于對(duì)照組(P0.05)。2.在結(jié)腸傳輸試驗(yàn)72小時(shí)標(biāo)記物排出粒數(shù)方面,兩組均較治療前有明顯增加(P0.05),且治療組增加幅度明顯優(yōu)于對(duì)照組(P0.05)。3.在便秘癥狀總積分方面,兩組均較治療前有明顯降低(P0.05),且治療組降低幅度明顯優(yōu)于對(duì)照組(P0.05)。4.治療組總有效率83.33%,對(duì)照組總有效率73.33%,兩組總體療效存在差異(P0.05)。5.兩組治療期間均未出現(xiàn)明顯不良反應(yīng)及毒副作用,說明兩組藥物安全性好。結(jié)論:小柴胡湯加減治療慢傳輸型便秘(腸道氣滯型)在改善患者焦慮、抑郁癥狀,增加結(jié)腸傳輸試驗(yàn)72小時(shí)標(biāo)記物排出粒數(shù),降低便秘癥狀總積分及臨床療效等方面均優(yōu)于對(duì)照組,安全有效,值得臨床應(yīng)用與推廣。
[Abstract]:Objective: to analyze the therapeutic effect of Xiaocaihu decoction on slow transit constipation (intestinal qi stagnation type) and explore its mechanism. Materials and methods: all the data were selected from January 2015 to June 2016 in the third affiliated Hospital of Liaoning University of traditional Chinese Medicine (Liaoning anorectal Hospital), which were diagnosed as slow transit constipation (intestinal qi stagnation type). There were 64 cases. The patients were randomly divided into treatment group (Xiaochaihu decoction subtraction group) and control group (Muxiang areca pill group). The treatment group was treated with Xiaochaihu decoction, water decoction, 3 times a day, 100 ml / time; the control group was treated with Muxiang betel nut pills, orally, 3 times a day, 1 bag per time. The two groups were treated with 2 weeks as a course of treatment, and the results were statistically analyzed after 2 courses of treatment. The scores of anxiety and depression before and after treatment, the number of markers excreted in 72 hours, the total score of constipation symptoms, the clinical efficacy and the safety of the two groups were observed. The clinical data were statistically analyzed by SPSS17.0 software and the results were analyzed and evaluated. The result is 1: 1. In terms of anxiety and depression scores, the two groups were significantly lower than before treatment (P0.05), and the treatment group significantly better than the control group (P0.05). 2. In colon transmission test 72 hours after treatment, the number of markers excreted from both groups were significantly increased (P0.05), and the treatment group was significantly better than the control group (P0.05). 3. In the total score of constipation symptoms, both groups were significantly lower than before treatment (P0.05), and the treatment group significantly better than the control group (P0.05). 4. The total effective rate of the treatment group was 83.33 and the total effective rate of the control group was 73.33. There was a difference between the two groups (P0.05). There were no obvious adverse reactions and side effects in both groups, indicating that the two groups were safe. Conclusion: Xiaochaihu decoction can improve anxiety and depression in patients with slow transit constipation (intestinal qi stagnation) and increase the number of markers excreted in 72 hours of colon transit test. Reducing the total score of constipation symptoms and clinical efficacy are better than the control group, safe and effective, worthy of clinical application and promotion.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R256.35

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