【摘要】：目的:觀察藥線植入療法治療結(jié)腸慢傳輸便秘的臨床研究。方法:將92例結(jié)腸慢傳輸便秘患者,隨機分為藥線治療組、羊腸線對照組、口服枸緣酸莫沙比利對照組。其中藥線治療組31例患者;羊腸線對照組30例患者,口服枸櫞酸莫沙必利組29例患者。藥線治療組和羊腸線對照組均治療1次,口服枸櫞酸莫沙必利組服藥2周。觀察三組患者分別在治療前、第2周、第4周和第6周的各癥狀評分及總有效率。結(jié)果:1.第2周,藥線治療組與羊腸線對照組和枸櫞酸莫沙必利對照組三組患者各癥狀較治療前均有所改善,藥線治療組總有效率為96.8%,羊腸線對照組總有效率為90.0%,口服枸緣酸莫沙比利對照組總有效率為86.2%,P0.05,無統(tǒng)計學意義,三組患者第2周療效相互之間無明顯差異。2.第4周,治療組總有效率為96.8%,羊腸線對照組總有效率為90.0%,停藥兩周后枸緣酸莫沙比利對照組第4周總有效率為37.9%,藥線治療組與羊腸線對照組相比較,P0.05,無統(tǒng)計學意義;藥線治療組與口服枸緣酸莫沙比利對照組、羊腸線對照組與口服枸緣酸莫沙比利對照組相比較,P0.01有統(tǒng)計學意義,提示藥線治療組與羊腸線對照組第4周療效比較無明顯差異,藥線治療組和羊腸線對照組第4周的總有效率明顯優(yōu)于口服枸緣酸莫沙比利對照組。3.第6周,治療組總有效率為96.8%,羊腸線對照組總有效率90.0%,停藥四周后的口服藥物對照組第6周總有效率為27.6%,藥線治療組與羊腸線對照組相比較,P0.05,藥線治療組與口服藥物對照組、羊腸線對照組與口服藥物對照組比較,均為P0.01,提示第6周治療組與羊腸線對照組總有效率無明顯差異,治療組與羊腸線對照組總有效率明顯優(yōu)于口服藥物對照組。4.癥狀評分方面,排便費力度、排便時間癥狀評分,治療組在第2周、第4周、第6周與羊腸線對照組及枸緣酸莫沙比利對照組相比,均P0.05,有統(tǒng)計學意義,提示治療組在第2周、第4周、第6周排便費力度、排便時間上療效優(yōu)于羊場線對照組及枸緣酸莫沙比利對照組。余癥狀評分方面,藥線治療組與羊腸線對照組在第2周、第4周、第6周中,均為P0.05,無統(tǒng)計學意義。結(jié)論:藥線植入療法治療結(jié)腸慢傳輸便秘療效顯著,遠期療效評價,與羊腸線對照組相比無明顯差異,與口服藥物對照組相比差異明顯。癥狀改善方面,在排便費力度和排便時間上,藥線植入療法優(yōu)于羊腸線對照組。
[Abstract]:Objective: to observe the clinical study of colonic slow transit constipation treated by drug line implantation. Methods: 92 patients with colonic slow transit constipation were randomly divided into drug therapy group, sheep intestinal line control group and oral moxapride citrate control group. There were 31 patients in the drug line group, 30 patients in the intestinal line control group and 29 patients in the oral mosapride citrate group. The drug line treatment group and the intestinal line control group were treated once, oral mosapride citrate group for 2 weeks. The symptom scores and the total effective rate of the three groups were observed before, 2, 4 and 6 weeks after treatment. The result is 1: 1. In the second week, the symptoms of the three groups were improved compared with those of the control group, the control group and the mosapride citrate group. The total effective rate of the drug line treatment group was 96.8um, the total effective rate of the sheep intestine line control group was 90.0 and the total effective rate of the oral moxapride citrate group was 86.2p 0.05. There was no significant difference between the three groups at the 2nd week. At the 4th week, the total effective rate of the treatment group was 96.8g, the total effective rate of the control group was 90.0 and the total effective rate of moxapride citrate was 37.9% in the control group two weeks after the withdrawal of the drug. There was no significant difference between the treatment group and the control group (P 0.05). There was significant difference between the drug line group and the oral moxapride citrate control group, the sheep intestinal line control group and the oral moxapride citrate control group, which indicated that there was no significant difference between the drug line treatment group and the sheep intestinal line control group at the 4th week. The total effective rate of the drug line therapy group and the sheep intestinal line control group was significantly better than that of the oral moxapride citrate group. 3. At the 6th week, the total effective rate in the treatment group was 96.8, the total effective rate in the control group was 90.0, the total effective rate in the oral drug control group after four weeks was 27.60.The total effective rate in the drug line treatment group was higher than that in the sheep intestine line control group, and that in the drug line treatment group was higher than that in the sheep intestinal line control group, and the drug line treatment group and the oral drug control group. Compared with the oral drug control group, the total effective rate of the treatment group and the control group was not significantly different at the 6th week, and the total effective rate of the treatment group and the control group was significantly better than that of the oral drug control group. Symptom score, defecation fee, defecation time symptom score, the treatment group in the 2nd week, 4th week, 6th week, compared with the control group of intestinal line and moxapride citrate control group, all have statistical significance, suggesting that the treatment group in the second week, In the 4th week, the 6th week, the defecation cost and the defecation time were better than those of the sheep farm line control group and the moxapride citrate control group. The scores of residual symptoms in the treatment group and the control group were all P0.05 in the 2nd week, 4th week and 6th week, with no statistical significance. Conclusion: the treatment of colonic slow transit constipation with drug thread implantation has a significant effect. The long-term curative effect evaluation has no significant difference compared with the control group of sheep's intestinal line, and the difference is obvious compared with the oral drug control group. In the improvement of symptoms, the drug line implantation therapy was superior to the control group in defecation cost and defecation time.
【學位授予單位】：云南中醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R256.35

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