【摘要】：目的根據(jù)治療前后鼻炎患者癥狀評分以及血液中IgE數(shù)值的變化程度,觀察蒙藥十三味紅花密訣丸治療過敏性鼻炎的臨床療效。方法將62例患者病程1年以上過敏性鼻炎患者,按入組時間先后順序,隨機分為蒙藥組(治療組)與中藥組(對照組),蒙藥組32例,中藥組30例。蒙藥組患者口服十三味紅花密訣丸,每日2次,一次10粒,中藥組患者口服千柏鼻炎片,每日3次,一次4片,蒙藥組與中藥組均服藥4周。建立患者資料調(diào)查表與癥狀積分表,記錄患者治療前與服藥滿一周后的癥狀積分,記錄患者治療前后血液中IgE數(shù)值。將原始數(shù)據(jù)錄入Excel,對所有數(shù)據(jù)進行整理。用SPSS13.0統(tǒng)計軟件對數(shù)據(jù)進行處理分析,評價療效。結(jié)果在癥狀評分方面,兩組患者治療后癥狀評分較治療前癥狀評分,有明顯下降,有極為顯著差異(P0.01),說明兩種藥物均能夠有效改善過敏性鼻炎患者的臨床癥狀;組間對比,蒙藥組患者在第1周服藥后,與服藥前的癥狀積分差值明顯大于中藥組,統(tǒng)計學有極顯著差異(P0.01),第2周與第3周兩組患者癥狀積分差值沒有統(tǒng)計學差異(P0.05),第4周蒙藥組患者癥狀積分差值較中藥組患者有顯著差異(P0.05);在血液IgE方面,兩組患者治療后IgE數(shù)值與治療前相比,有一定程度下降,有極為顯著差異(P0.01),說明兩種藥物均能有效降低血液中IgE數(shù)值;蒙藥組治療前后血液IgE差值與中藥組IgE差值進行比較,無差異(P0.05),說明兩種藥物在降低血液IgE數(shù)值方面無差異。結(jié)論兩種藥物均能夠有效降低過敏性鼻炎患者的臨床癥狀,但十三味紅花密訣丸能夠更好的改善過敏性鼻炎患者的典型癥狀;在影響過敏性鼻炎患者體內(nèi)血液IgE數(shù)值方面,兩種藥物均有療效,無明顯差異(P0.05)。蒙藥十三味紅花密訣丸不但能改善過敏性鼻炎的典型癥狀,也能降低患者血清總IgE水平,從而達到治療過敏性鼻炎,可以在臨床上推廣使用。
[Abstract]:Objective to observe the clinical effect of 13 kinds of Mongolian medicine on allergic rhinitis according to the change of symptom score and IgE value of rhinitis patients before and after treatment. Methods 62 patients with allergic rhinitis were randomly divided into Mongolian medicine group (treatment group) and Chinese medicine group (control group), Mongolian medicine group (32 cases) and Chinese medicine group (30 cases). The patients in the Mongolian medicine group were given 13 kinds of safflower secret pills twice a day, 10 tablets once a day, and the patients in the traditional Chinese medicine group took Qianbai rhinitis tablets 3 times a day, 4 tablets once a day, and both the Mongolian medicine group and the Chinese medicine group took medicine for 4 weeks. The symptom scores before and after treatment were recorded and the IgE values of blood were recorded before and after treatment. Input raw data into Excel and organize all data. SPSS13.0 statistical software was used to analyze the data and evaluate the curative effect. Results in the aspect of symptom score, the symptom score of the two groups after treatment was significantly lower than that before treatment (P0.01), indicating that the two drugs can effectively improve the clinical symptoms of patients with allergic rhinitis. The difference of symptom score between the Mongolian medicine group and the pre-medication group was significantly higher than that in the traditional Chinese medicine group after the first week of medication. There was very significant difference in statistics (P0.01). There was no significant difference between the two groups in symptom score difference between the second week and the third week (P0.05). At the 4th week, there was significant difference between the Mongolian medicine group and the traditional Chinese medicine group (P0.05); in blood IgE, there was no significant difference between the two groups (P0.05). Compared with before and after treatment, the IgE value of the two groups decreased to a certain extent, and there was a significant difference (P0.01), indicating that the two drugs can effectively reduce the value of IgE in the blood, and the difference of blood IgE between the Mongolian medicine group and the traditional Chinese medicine group before and after treatment was compared with that of the traditional Chinese medicine group. There was no difference (P0.05), indicating that there was no difference between the two drugs in reducing blood IgE values. Conclusion both drugs can effectively reduce the clinical symptoms of patients with allergic rhinitis, but Shiwei Honghua Mi Pill can improve the typical symptoms of allergic rhinitis patients, and affect the IgE value of blood in allergic rhinitis patients. There was no significant difference between the two drugs (P0.05). The Mongolian medicine Thirteen Red Flower Milk Pill can not only improve the typical symptoms of allergic rhinitis, but also reduce the serum total IgE level of the patients, so as to achieve the treatment of allergic rhinitis, and can be popularized in clinical use.
【學位授予單位】：內(nèi)蒙古醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R29

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