中草藥治療艾滋病隨機(jī)對照臨床試驗(yàn)的系統(tǒng)綜述
發(fā)布時間：2018-08-12 20:01
【摘要】：目的評價中醫(yī)藥治療艾滋病的療效和安全性。方法納入文獻(xiàn)為中草藥治療艾滋病的隨機(jī)對照臨床試驗(yàn)。全面檢索Pub Med、Cochrane對照試驗(yàn)注冊中心及CNKI、維普、萬方和CBM數(shù)據(jù)庫(截至2013年4月)。自行設(shè)計資料提取表提取資料,采用Cochrane手冊推薦的質(zhì)量評價工具評價文獻(xiàn)質(zhì)量,應(yīng)用RevMan5.1軟件進(jìn)行數(shù)據(jù)分析。結(jié)果 3個試驗(yàn)評價為低風(fēng)險偏倚,其他均為高風(fēng)險偏倚。艾靈顆粒與安慰劑比較(2個試驗(yàn),120名受試者)結(jié)果顯示:CD4細(xì)胞計數(shù)增加:MD95.47,95%CI:(41.52,149.41);健康相關(guān)生活質(zhì)量評分:MD4.80,95%CI(2.63,6.96)。湘A2聯(lián)合傳統(tǒng)治療與傳統(tǒng)治療聯(lián)合安慰劑比較(2個試驗(yàn),120名受試者):CD4細(xì)胞計數(shù)增加:MD42.92,95%CI:(4.92,80.86)。艾靈顆粒聯(lián)合傳統(tǒng)治療與傳統(tǒng)治療聯(lián)合安慰劑比較(5個試驗(yàn),334名受試者),CD4細(xì)胞計數(shù)增加:MD60.82,95%CI:(27.00,94.65)。納入試驗(yàn)無嚴(yán)重不良反應(yīng)報告。結(jié)論部分中草藥如艾靈顆粒等在艾滋病的治療中表現(xiàn)出潛在優(yōu)勢療效且無嚴(yán)重不良反應(yīng),但由于納入試驗(yàn)的質(zhì)量較低和中草藥治療的異質(zhì)性較大,需要慎重解釋結(jié)果并在將來的研究中加以驗(yàn)證。
[Abstract]:Objective to evaluate the efficacy and safety of traditional Chinese medicine (TCM) in the treatment of AIDS. Methods A randomized controlled clinical trial of Chinese herbal medicine for the treatment of AIDS was included in the literature. To search the Pub Medsite Cochrane controlled trial Registry and CNKI, Weip, Wanfang and CBM databases (as of April 2013). The data extraction table was designed by ourselves, and the quality evaluation tool recommended by Cochrane manual was used to evaluate the quality of literature, and the data was analyzed by RevMan5.1 software. Results three trials were evaluated as low risk bias, others were high risk bias. Compared with placebo (120 subjects in two trials), the results of Ai Ling granule showed that the CD4 cell count was increased by 10% MD95.47 and 95CI: (41.52149.41), and the health-related quality of life score was: MD4.809595 CI (2.63m6.96). Compared with traditional therapy and placebo, Xiang A2 combined with traditional therapy and placebo (120 subjects in two trials) showed an increase in the CD4 cell count of 10% MD42.92% 95 CI: (4.92% 80.86). Compared with traditional therapy combined with placebo, Ai Ling granule increased CD4 cell count in 5 subjects (n = 334) and increased CD _ 4 cell count in 10% MD60.82 ~ (95) CI: (27.00 鹵94.65). No serious adverse reactions were reported in the trial. Conclusion some Chinese herbal medicines, such as Ai Ling granule, have potential advantages in the treatment of AIDS without serious adverse reactions, but due to the low quality of the trial and the heterogeneity of the Chinese herbal medicine treatment. The results need to be interpreted carefully and verified in future studies.
【作者單位】： 北京中醫(yī)藥大學(xué)循證醫(yī)學(xué)中心;
【基金】：中國全球基金艾滋病項(xiàng)目2012年支持社會組織參與艾滋病防治工作項(xiàng)目(No.CSO-2012-研51) 2013年教育部新世紀(jì)優(yōu)秀人才支持計劃項(xiàng)目(No.NCET-13-0694)
【分類號】：R259
[Abstract]:Objective to evaluate the efficacy and safety of traditional Chinese medicine (TCM) in the treatment of AIDS. Methods A randomized controlled clinical trial of Chinese herbal medicine for the treatment of AIDS was included in the literature. To search the Pub Medsite Cochrane controlled trial Registry and CNKI, Weip, Wanfang and CBM databases (as of April 2013). The data extraction table was designed by ourselves, and the quality evaluation tool recommended by Cochrane manual was used to evaluate the quality of literature, and the data was analyzed by RevMan5.1 software. Results three trials were evaluated as low risk bias, others were high risk bias. Compared with placebo (120 subjects in two trials), the results of Ai Ling granule showed that the CD4 cell count was increased by 10% MD95.47 and 95CI: (41.52149.41), and the health-related quality of life score was: MD4.809595 CI (2.63m6.96). Compared with traditional therapy and placebo, Xiang A2 combined with traditional therapy and placebo (120 subjects in two trials) showed an increase in the CD4 cell count of 10% MD42.92% 95 CI: (4.92% 80.86). Compared with traditional therapy combined with placebo, Ai Ling granule increased CD4 cell count in 5 subjects (n = 334) and increased CD _ 4 cell count in 10% MD60.82 ~ (95) CI: (27.00 鹵94.65). No serious adverse reactions were reported in the trial. Conclusion some Chinese herbal medicines, such as Ai Ling granule, have potential advantages in the treatment of AIDS without serious adverse reactions, but due to the low quality of the trial and the heterogeneity of the Chinese herbal medicine treatment. The results need to be interpreted carefully and verified in future studies.
【作者單位】： 北京中醫(yī)藥大學(xué)循證醫(yī)學(xué)中心;
【基金】：中國全球基金艾滋病項(xiàng)目2012年支持社會組織參與艾滋病防治工作項(xiàng)目(No.CSO-2012-研51) 2013年教育部新世紀(jì)優(yōu)秀人才支持計劃項(xiàng)目(No.NCET-13-0694)
【分類號】：R259
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相關(guān)期刊論文 前10條
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本文編號：2180207
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