【摘要】：目的:本次研究通過觀察四合一方對胃癌前病變的治療作用和臨床癥狀的改善情況,探討四合一方的可能治療機制,為中醫(yī)對胃癌前病變的治療探索新的治療方法和思路。方法:選擇符合納入標(biāo)準(zhǔn)的胃癌前病變患者62例,按中醫(yī)辨證分型納入肝胃不和證、脾胃虛弱證、脾胃濕熱證、胃絡(luò)瘀血證治療;使用四合一方辨證加減,服藥2個療程,每個療程3個月。采用自身前后對照分析,觀察療效時觀察各種證型治療前后的中醫(yī)癥候積分,四種證型組間的療效,治療前后Hp陽性例數(shù),治療前后病理檢查的萎縮、腸上皮化生、異型增生。結(jié)果:1.各種證型治療前后中醫(yī)癥候積分比較,治療后積分比治療前積分明顯下降,差異有統(tǒng)計學(xué)意義(P0.05)。2.四種證型中醫(yī)癥候療效組間比較,差異無統(tǒng)計學(xué)意義(P0.05)。3.治療前后Hp陽性比較,治療后Hp陽性比治療前下降,差異有統(tǒng)計學(xué)意義(P0.05)。4.治療前后病理檢查比較,治療后萎縮、腸化、異型增生比治療前改善,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:1.四合一方能靈活運用于不同的胃癌前病變證型并能改善患者臨床癥狀。2.四合一方能逆轉(zhuǎn)胃癌前病變,減緩胃癌前病變的進展。
[Abstract]:Objective: to explore the possible therapeutic mechanism of Siyinfang in the treatment of precancerous lesions of gastric cancer by observing the therapeutic effect and the improvement of clinical symptoms of SYF in order to explore a new treatment method and train of thought for the treatment of precancerous lesions of gastric cancer in traditional Chinese medicine (TCM). Methods: Sixty-two patients with gastric precancerous lesions who met the inclusive criteria were selected to be treated with syndrome of disharmony of liver and stomach, deficiency of spleen and stomach, dampness and heat of spleen and stomach, and blood stasis of stomach according to syndrome differentiation of TCM. Each course of treatment was 3 months. The syndromes of different syndromes before and after treatment, the curative effect among the four syndromes groups, the number of HP positive cases before and after treatment, the atrophy of pathological examination before and after treatment, intestinal metaplasia and dysplasia were observed. The result is 1: 1. All kinds of syndrome before and after treatment of traditional Chinese medicine syndrome score comparison, after treatment the integral scores were significantly lower than before treatment, the difference was statistically significant (P0.05). 2. There was no significant difference between the four syndromes of TCM syndromes (P0.05). 3. HP positive comparison before and after treatment, HP positive after treatment than before treatment, the difference was statistically significant (P0.05). 4. Before and after treatment pathological examination comparison, after treatment atrophy, intestinal metaplasia, dysplasia than before treatment improved, the difference was statistically significant (P0.05). Conclusion 1. The four-in-one formula can be used flexibly in different types of gastric precancerous lesions and can improve the clinical symptoms. 2. 2. The four-in-one prescription can reverse gastric precancerous lesion and slow down the progress of gastric precancerous lesion.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259;R273

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 楊宗保;王晨光;陳嬌龍;王紅;王亞東;馬富強;;艾灸對慢性萎縮性胃炎癌前病變大鼠胃黏膜細(xì)胞增殖因子的影響[J];中國針灸;2015年12期

2 劉曉;單兆偉;;單兆偉教授治療胃粘膜不典型增生臨床經(jīng)驗[J];中醫(yī)藥學(xué)報;2015年03期

3 張明;鄧毅;;甘草及其有效成分的藥效學(xué)研究進展[J];西部中醫(yī)藥;2015年04期

4 顧志堅;唐人彥;林江;李熠萌;張正利;蔡淦;;莪連顆粒治療脾虛瘀熱型慢性萎縮性胃炎伴腸化生臨床隨機對照研究[J];上海中醫(yī)藥雜志;2015年04期

5 屈小媛;武玉祥;張久磊;;石斛化學(xué)成分與藥理活性研究進展[J];天津農(nóng)業(yè)科學(xué);2015年04期

6 康英梅;;活血通絡(luò)法用于慢性萎縮性胃炎癌前病變治療觀察[J];中國醫(yī)學(xué)創(chuàng)新;2015年06期

7 林麗霞;梁國瑞;陳燕;薛銀萍;;茯苓多糖的免疫效應(yīng)和抗腫瘤作用研究進展[J];環(huán)球中醫(yī)藥;2015年01期

8 Hwa Mi Kang;Gwang Ha Kim;Do Youn Park;Hong Ryeol Cheong;Dong Hoon Baek;Bong Eun Lee;Geun Am Song;;Magnifying endoscopy of gastric epithelial dysplasia based on the morphologic characteristics[J];World Journal of Gastroenterology;2014年42期

9 王義相;;益氣活血法治療胃癌前病變的療效觀察[J];中國處方藥;2014年09期

10 李偉偉;張國偉;;陳皮黃酮類成分研究進展[J];中國醫(yī)學(xué)創(chuàng)新;2014年24期

相關(guān)博士學(xué)位論文 前1條

1 許睿;救必應(yīng)化學(xué)成分研究及抗腫瘤活性成分初步篩選[D];廣州中醫(yī)藥大學(xué);2009年

，

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