【摘要】：目的:通過觀察龍膽瀉肝湯合小承氣湯在治療酒精性肝炎(肝膽濕熱證)的臨床療效,以及將本方進(jìn)行對癥加減應(yīng)用來探討中醫(yī)在治療酒精性肝炎(以下簡稱AH)的療效,通過統(tǒng)計(jì)學(xué)分析,客觀的評價龍膽瀉肝湯合小承氣湯在治療酒精性肝炎(肝膽濕熱證)的臨床有效性及安全性。方法:全部患者均來自長春中醫(yī)藥大學(xué)附屬醫(yī)院肝脾胃病科療區(qū)及門診,并符合納入標(biāo)準(zhǔn)的60例酒精性肝炎(肝膽濕熱證)的患者,采用隨機(jī)對照分組法,分成治療組和對照組,各30例。治療組采用龍膽瀉肝湯合小承氣湯150ml/次,日2次口服,對照組采用肝毒凈顆粒,8g/次,日3次沖服,兩組療程均為8周。觀察其治療前后中醫(yī)癥候積分的變化,檢測并記錄肝功能、消化系超聲的變化。最后根據(jù)相應(yīng)的療效評價標(biāo)準(zhǔn),做出評價。結(jié)果:所納入的60例患者均按照治療方案完成本次臨床研究。療效顯示:治療組30例患者,顯效16例(53.33%),有效12例(40%),無效2例(6.67%),總有效率為93.33%;對照組30例,顯效9例(30%),有效13例(53.33%),無效8例(26.67%),總有效率為83.33%,通過統(tǒng)計(jì)學(xué)分析,治療組療效優(yōu)于對照組(P0.05)有統(tǒng)計(jì)學(xué)意義;兩組在中醫(yī)癥狀方面及改善肝功能、消化系超聲等方面較治療前均有改善,但治療組使用的龍膽瀉肝湯合小承氣湯在AST、GGT方面優(yōu)于使用肝毒凈顆粒的對照組。在用藥安全性方面,兩組均未發(fā)現(xiàn)不良反應(yīng),運(yùn)用龍膽瀉肝湯合小承氣湯安全性良好。結(jié)論:臨床上應(yīng)用龍膽瀉肝湯合小承氣湯治療酒精性肝炎(肝膽濕熱證),能明顯改善患者的臨床癥狀,促進(jìn)肝功能的恢復(fù),并減輕酒精性肝炎的程度。本方在試驗(yàn)過程中未見明顯的不良反應(yīng)及毒副作用,并且臨床療效滿意,值得推廣。
[Abstract]:Objective: to observe the clinical effect of Longdan Xiegan decoction combined with Xiaochengqi decoction in the treatment of alcoholic hepatitis (liver and gallbladder dampness and heat syndrome), and to explore the therapeutic effect of traditional Chinese medicine on alcoholic hepatitis (AH). Objective to evaluate the clinical efficacy and safety of Longdan Xiegan decoction and Xiaochengqi decoction in the treatment of alcoholic hepatitis (liver and gallbladder damp-heat syndrome). Methods: all the patients were from the Department of liver, spleen and stomach of the affiliated Hospital of Changchun University of traditional Chinese Medicine and outpatients, and 60 cases of alcoholic hepatitis (dampness and heat of liver and gallbladder) were included. They were divided into treatment group and control group with 30 cases in each group. The treatment group was treated with Longdan Xiegan decoction and Xiaochengqi decoction 150ml/ twice a day, while the control group was treated with Gandujing granule 8 g / time, 3 times a day. The course of treatment in both groups was 8 weeks. Observe the change of TCM symptom integral before and after treatment, detect and record the changes of liver function and digestive system ultrasound. Finally, according to the corresponding evaluation criteria, the evaluation is made. Results: the clinical study was completed in 60 patients according to the treatment protocol. The results showed that in the treatment group, 16 cases (53.33%) were significantly effective, 12 cases (40%) were effective, 2 cases (6.67%) were ineffective, the total effective rate was 93.33%, while in the control group, there were 30 cases (30%), 9 cases (30%), 13 cases (53.33%) were effective, 8 cases (26.67%) were ineffective, the total effective rate was 83.33%, and the total effective rate was 83.33%. The curative effect of the treatment group was better than that of the control group (P0.05). But the Gentian Xiegan decoction combined with Xiaochengqi decoction in the treatment group was superior to the control group in terms of GGT. There were no adverse reactions in both groups, and the safety of Gentian Xiegan decoction and Xiaochengqi decoction was good. Conclusion: the clinical application of Longdan Xiegan decoction and Xiaochengqi decoction in the treatment of alcoholic hepatitis (damp-heat syndrome of liver and gallbladder) can obviously improve the clinical symptoms of the patients, promote the recovery of liver function, and reduce the degree of alcoholic hepatitis. There were no obvious adverse reactions and side effects in the trial, and the clinical effect was satisfactory. It is worth popularizing.
【學(xué)位授予單位】：長春中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R259

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 梁衛(wèi);吳承玉;梁濤;;清肝利濕解酒湯對酒精性脂肪肝大鼠肝損傷保護(hù)作用研究[J];中國實(shí)驗(yàn)方劑學(xué)雜志;2013年04期

2 殷曉軒;尹常健;;酒精性肝病中醫(yī)用藥規(guī)律探討[J];中國實(shí)驗(yàn)方劑學(xué)雜志;2011年12期

3 厲有名;范建高;王炳元;陸倫根;施軍平;牛俊奇;沈薇;徐有青;;酒精性肝病診療指南(2010年1月修訂)[J];現(xiàn)代醫(yī)藥衛(wèi)生;2011年06期

4 解慶凡;張一昕;王建華;王曉貞;郭文平;;脂脈寧對大鼠酒精性脂肪肝的防治作用[J];中國中醫(yī)急癥;2011年03期

5 解慶凡;王建華;王曉貞;郭文平;張一昕;;脂脈寧對酒精性脂肪肝大鼠血清和肝組織SOD活性及MDA含量的影響[J];中國中醫(yī)急癥;2011年01期

6 劉紅云;;酒精性肝病的研究進(jìn)展[J];山東醫(yī)學(xué)高等專科學(xué)校學(xué)報(bào);2010年04期

7 李雪萍;王煥英;;轉(zhuǎn)化生長因子β1與肝纖維化關(guān)系[J];中國實(shí)用醫(yī)藥;2009年33期

8 王立新;宓余強(qiáng);徐亮;;酒精性肝炎中醫(yī)證型臨床分析[J];中國民族民間醫(yī)藥;2009年11期

9 朱小區(qū);曹家麟;吳春明;歐陽欽;;二子清肝湯治療酒精性肝炎52例療效觀察[J];浙江中醫(yī)雜志;2008年01期

10 朱肖鴻;朱強(qiáng);葉蕾;孫明洪;倪桂寶;姚定國;丁靜;陳春曉;;枳i子對大鼠酒精性脂肪肝的預(yù)防作用及機(jī)制[J];中西醫(yī)結(jié)合肝病雜志;2007年04期

，

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