發(fā)布時(shí)間：2018-07-15 08:57

【摘要】：目的:觀察蠶矢湯加減及其聯(lián)合秋水仙堿治療痛風(fēng)性關(guān)節(jié)炎濕熱蘊(yùn)結(jié)證的療效及安全性。方法:將258例患者隨機(jī)分為中藥組、西藥組和中西藥組,每組各86例。中藥組口服蠶矢湯加減,西藥組口服秋水仙堿,中西藥組同時(shí)口服蠶矢湯加減聯(lián)合秋水仙堿,療程均為14 d。觀察治療前后各組臨床癥狀,血清尿酸(SUA),血沉(ESR),C-反應(yīng)蛋白(CRP)和白細(xì)胞介素-6(IL-6)的變化;比較各組總有效率、不良反應(yīng)發(fā)生率及隨訪3個(gè)月患者的復(fù)發(fā)率。結(jié)果:治療過程中藥組剔除3例,西藥組剔除2例,中西藥剔除5例。中西藥組總有效率93.8%,優(yōu)于中藥組的81.9%和西藥組的83.3%(P0.05),中藥組與西藥組比較無明顯差異;中西藥組各臨床癥狀和實(shí)驗(yàn)室檢查指標(biāo)改善較中藥組和西藥組更為明顯(P0.05),中藥組與西藥組比較無統(tǒng)計(jì)學(xué)意義;不良反應(yīng)發(fā)生率中藥組(3.6%)中西藥組(60.5%)西藥組(82.1%)(P0.05);復(fù)發(fā)率中西藥組(7.4%)中藥組(20.5%)西藥組(26.1%)(P0.05)。結(jié)論:蠶矢湯加減治療痛風(fēng)性關(guān)節(jié)炎濕熱蘊(yùn)結(jié)證的療效與西藥秋水仙堿無明顯差異,說明其具有有效性,且不良反應(yīng)的發(fā)生率和復(fù)發(fā)率較秋水仙堿低;蠶矢湯加減聯(lián)合秋水仙堿治療痛風(fēng)性關(guān)節(jié)炎濕熱蘊(yùn)結(jié)證具有協(xié)同增效的作用,療效優(yōu)于單用蠶矢湯加減或秋水仙堿,且可降低秋水仙堿的不良反應(yīng)、復(fù)發(fā)率低。
[Abstract]:Objective: to observe the efficacy and safety of silkworm Yam decoction and colchicine in treating damp-heat accumulation syndrome of gouty arthritis. Methods: 258 patients were randomly divided into Chinese medicine group, western medicine group and western medicine group with 86 cases in each group. The Chinese medicine group was treated with silkworm decoction, the western medicine group with colchicine, the traditional Chinese medicine group with the combination of silkworm decoction and colchicine. The course of treatment was 14 days. The clinical symptoms, serum uric acid (SUA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and interleukin-6 (IL-6) were observed before and after treatment, the total effective rate, the incidence of adverse reactions and the recurrence rate of the patients were compared. Results: in the course of treatment, 3 cases were eliminated in Chinese medicine group, 2 cases in western medicine group and 5 cases in Chinese and western medicine group. The total effective rate of the Chinese and western medicine group was 93.8%, which was better than that of the traditional Chinese medicine group (81.9%) and the western medicine group (83.3%) (P0.05). There was no significant difference between the Chinese medicine group and the western medicine group. The improvement of clinical symptoms and laboratory examination indexes in the Chinese and western medicine group was more obvious than that in the traditional Chinese medicine group and the western medicine group (P0.05), but there was no significant difference between the traditional Chinese medicine group and the western medicine group. The incidence of adverse reactions was 3.6% in TCM group, 60.5% in TCM group, 82.1% in western medicine group (P0.05), and the recurrence rate in TCM group (7.4%), traditional Chinese medicine group (20.5%) and western medicine group (26.1%) (P0.05). Conclusion: there is no significant difference between YYD and western medicine colchicine in the treatment of damp-heat accumulation syndrome of gouty arthritis, which indicates that it is effective, and the incidence and recurrence rate of adverse reactions is lower than that of colchicine. The combination of silkworm yam decoction and colchicine in the treatment of damp-heat accumulation syndrome of gouty arthritis has synergistic effect, which is superior to that of silkworm Yayi decoction alone or colchicine, and can reduce the adverse reaction of colchicine, and the recurrence rate is low.
【作者單位】： 河南省中醫(yī)院;
【基金】：河南省科學(xué)技術(shù)廳科技發(fā)展計(jì)劃項(xiàng)目(14B360018)
【分類號(hào)】：R259

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1 莫頂立;蠶矢湯治療膽石癥50例[J];新中醫(yī);1994年07期

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本文編號(hào)：2123532