本文選題：滋陰清熱化痰法 + 肺纖維化(虛熱證)��； 參考：《遼寧中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:通過觀察滋陰清熱化痰法治療肺纖維化(虛熱證)的主要癥狀(氣短、咳痰、胸痛)、次要癥狀(咳嗽、口燥咽干)、肺功能、胸部HRCT、血氧飽和度、生活質(zhì)量問卷評分、綜合療效評定,以探討滋陰清熱化痰法治療肺纖維化(虛熱證)的臨床療效。方法:選取70例西醫(yī)診斷為特發(fā)性肺纖維化和繼發(fā)性肺纖維化中醫(yī)證屬虛熱證患者。采用隨機數(shù)字表法分為對照組和治療組,每組35例。對照組采用西醫(yī)常規(guī)的治療方案給予潑尼松口服;治療組在對照組治療的基礎(chǔ)上加用“保金湯”口服,療程均為12周。記錄治療前后兩組癥狀積分、肺功能、血氧飽和度、胸部HRCT、生活質(zhì)量評分、綜合療效評定。采用SPSS 22.0軟件進行統(tǒng)計分析。結(jié)果:1.中醫(yī)癥狀積分方面:(1)主要癥狀:(1)兩組治療方案在氣短、咳痰、胸痛積分方面,治療后積分均優(yōu)于同組治療前積分且差異顯著。(2)比較治療后氣短,咳痰,胸痛積分,治療組優(yōu)于對照組,差異顯著。(2)次要癥狀:(1)在咳嗽積分方面,兩組治療方案在治療后積分均優(yōu)于同組治療前積分且差異顯著。治療后積分比較,治療組優(yōu)于對照組,差異顯著。(2)在口燥咽干積分方面,治療組在治療后積分優(yōu)于治療前,差異顯著。治療后積分比較,治療組優(yōu)于對照組,差異顯著。(3)癥狀總積分:(1)兩組治療方案治療后總積分均優(yōu)于同組治療前總積分且差異顯著。(2)治療后總積分比較,治療組優(yōu)于對照組,差異顯著。2.西醫(yī)療效指標方面:(1)生活質(zhì)量評分:(1)兩組治療方案在癥狀表現(xiàn)、活動受限、心理情況方面,治療后積分均優(yōu)于同組治療前積分且差異顯著。(2)比較治療后癥狀表現(xiàn)、活動受限、心理情況,治療組均優(yōu)于對照組,差異顯著。(2)肺功能(TLC):兩組治療方案治療后較治療前改善均無統(tǒng)計學(xué)差異。(3)血氧飽和度方面:治療組治療后優(yōu)于治療前,差異顯著。(4)胸部HRCT方面:兩組治療后胸部HRCT變化比較沒有顯著差異。(5)綜合療效評定:對照組總有效率為51.61%,治療組總有效率為78.13%,治療組優(yōu)于對照組,差異顯著。結(jié)論:1.滋陰清熱化痰法在治療肺纖維化(虛熱證)的臨床療效顯著。2.滋陰清熱化痰法在改善肺纖維化(虛熱證)的臨床癥狀(氣短、咳痰、胸痛、咳嗽、口燥咽干)、生活質(zhì)量及總有效率均優(yōu)于西醫(yī)治療組。
[Abstract]:Objective: to observe the main symptoms (shortness of breath, expectoration, chest pain), secondary symptoms (cough, dry throat), pulmonary function, chest HRCTs, oxygen saturation of blood and quality of life (QOL) in the treatment of pulmonary fibrosis (deficiency heat syndrome) by the method of nourishing yin and clearing away heat and removing phlegm. Objective: to evaluate the clinical effect of nourishing yin and clearing away heat and removing phlegm in the treatment of pulmonary fibrosis (deficiency heat syndrome). Methods: 70 cases of TCM syndrome of idiopathic pulmonary fibrosis and secondary pulmonary fibrosis were selected. The patients were randomly divided into control group and treatment group with 35 cases in each group. The control group was given prednisone orally by routine western medicine, and the treatment group was treated with "Baojin decoction" for 12 weeks on the basis of the control group. Symptom score, pulmonary function, blood oxygen saturation, chest HRCTs, quality of life score and comprehensive curative effect were recorded before and after treatment. SPSS 22.0 software was used for statistical analysis. The result is 1: 1. TCM symptom integral: (1) the main symptoms: (1) the scores after treatment in the two groups were better than those before treatment in the two groups. (2) the scores of shortness of breath, expectoration and chest pain after treatment were significantly higher than those in the same group, (2) the scores of shortness of breath, expectoration and chest pain after treatment were significantly higher than those in the same group. The treatment group was superior to the control group, the difference was significant. (2) the secondary symptoms: (1) in cough integral, the two groups had better score after treatment than the same group before treatment and the difference was significant. After treatment, the treatment group is better than the control group, the difference is significant. (2) in the dry throat integral, the treatment group is better than before the treatment, the difference is significant. After treatment, the treatment group was superior to the control group, and the difference was significant. (3) the total symptom score: (1) the total score of the two groups was better than that of the same group before treatment and the difference was significant. (2) the treatment group was better than the control group, and the treatment group was better than the control group. The difference is significant. Western medicine curative effect index aspect: (1) quality of life score: (1) two groups of treatment plan in symptom performance, activity limitation, psychological condition, after treatment scores are better than the same group before treatment score and significant difference. (2) compare the symptoms after treatment, limited activity, The psychological condition of the treatment group was better than that of the control group, and the difference was significant. (2) the lung function (TLC): there was no significant difference between the two groups after treatment. (3) blood oxygen saturation: after treatment, the treatment group was better than before. (4) chest HRCT: there was no significant difference between the two groups after treatment. (5) Comprehensive efficacy evaluation: the total effective rate of the control group was 51.61 and the total effective rate of the treatment group was 78.13. The treatment group was superior to the control group, and the difference was significant. Conclusion 1. The clinical curative effect of nourishing yin and clearing away heat and removing phlegm is significant in the treatment of pulmonary fibrosis (deficiency heat syndrome). The method of nourishing yin and clearing away heat and removing phlegm can improve the clinical symptoms of pulmonary fibrosis (deficiency heat syndrome) (short breath, expectoration, chest pain, cough, dryness of throat), the quality of life and the total effective rate are better than that of western medicine treatment group.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R259

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本文編號：2114741