本文選題：燈盞生脈膠囊 + 缺血性中風(fēng)�。� 參考：《遼寧中醫(yī)雜志》2017年10期

【摘要】：目的:系統(tǒng)評價(jià)燈盞生脈膠囊治療缺血性中風(fēng)的療效。方法:檢索Pubmed、中國知網(wǎng)、維普數(shù)據(jù)庫、萬方數(shù)據(jù)庫等,全面檢索燈盞生脈膠囊治療缺血性中風(fēng)的隨機(jī)對照試驗(yàn),進(jìn)行文獻(xiàn)篩選、數(shù)據(jù)提取及方法學(xué)質(zhì)量評價(jià),采用Review Manager 5.2軟件進(jìn)行Meta分析。結(jié)果:本研究納入20個(gè)RCT,共3133名患者,Meta分析結(jié)果顯示:(1)療效方面,燈盞生脈膠囊在總有效率,中風(fēng)量表評分方面優(yōu)于對照組藥物[RR=1.22,95%CI(1.10,1.35),P0.05;MD=-3.85,95%CI(-5.73,-1.98),P0.05],而在改良Rankin量表評分及Barthel指數(shù)等方面療效相當(dāng)[MD=-0.40,95%CI(-1.13,0.33),P=0.28;MD=2.57,95%CI(-11.13,16.28),P=0.71];(2)生化指標(biāo)方面,燈盞生脈膠囊同傳統(tǒng)藥物相比,可改善纖維蛋白原及低密度脂蛋白等血清水平,差異具有統(tǒng)計(jì)學(xué)意義[MD=-1.15,95%CI(-2.05,-0.24),P0.05;MD=-0.64,95%CI(-0.89,-0.39),P0.05]。結(jié)論:目前臨床證據(jù)表明,燈盞生脈膠囊治療缺血性中風(fēng)療效確切。上述結(jié)果仍需高質(zhì)量的隨機(jī)對照試驗(yàn)進(jìn)行客觀評價(jià)。
[Abstract]:Objective: to evaluate the efficacy of breviscapine Shengmai capsule in the treatment of ischemic apoplexy. Methods: Pubmed, China Zhiwang, Weipu and Wanfang databases were searched, and the randomized controlled trial of Dengzhanshengmai capsule in treating ischemic apoplexy was searched. Literature screening, data extraction and evaluation of methodology quality were carried out. Meta-analysis was carried out with Review Manager 5.2 software. Results: twenty RCTs were included in this study. The results of Meta-analysis of 3133 patients showed that: (1) the total effective rate of Dengzengsheng Mai capsule was 1. The stroke scale score was better than that of the control group [RRRN 1.22995 CI (1.101.35) P0.05MD-3.85-95CI (-5.73U -1.98) P 0.05], but the effect on modified Rankin scale score and Barthel index was quite good [MD-0.4095CI (-1.130.33) P0.28MDT 2.5795 CI (-11.131316.28) P0.71]; (2) compared with traditional medicine, Dengshengmai capsule was more effective than traditional medicine. The serum levels of fibrinogen and low density lipoprotein were improved, and the difference was statistically significant [MD-1.1595 CI (-2.05 鹵-0.24) P 0.05 + MD-0.64 + 95 CI (-0.89U -0.39) (P0.05)]. Conclusion: the clinical evidence shows that Dengshengmai capsule is effective in the treatment of ischemic apoplexy. These results still need to be evaluated objectively in a high-quality randomized controlled trial.
【作者單位】： 廣州中醫(yī)藥大學(xué);廣州中醫(yī)藥大學(xué)DME中心;廣東省第二人民醫(yī)院;
【基金】：國家重大新藥創(chuàng)制專項(xiàng)-中藥新藥臨床試驗(yàn)技術(shù)平臺研究(2012ZX09303009-003)
【分類號】：R255.2

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