本文選題：登革熱 + 中醫(yī)療法　； 參考：《廣州中醫(yī)藥大學》2016年碩士論文

【摘要】：目的：本研究觀察醒腦靜注射液對登革熱(衛(wèi)氣同病證)患者的作用,通過其對中醫(yī)癥候積分、退熱天數(shù)、白細胞計數(shù)及血小板計數(shù)的影響,評價醒腦靜注射的療效及安全性,旨在為中醫(yī)藥治療登革熱提供一種臨床參考。方法：選取符合納入標準的54例登革熱(衛(wèi)氣同病證)為研究對象,隨機分為治療組和對照組,每組27例。對照組給予一般對癥支持治療：降溫、靜脈及口服補液、止血護胃等；治療組加用醒腦靜注射液20m靜脈滴注,一天一次,療程均為5天,使用時予0.9%氯化鈉250m1或5%葡萄糖250m1稀釋。觀察指標：中醫(yī)癥候積分、退熱天數(shù)、白細胞計數(shù)、血小板計數(shù)等。對比治療組與對照組治療前后及對照組與治療組組間的差異。結(jié)果：1.兩組患者在年齡、性別、皮疹發(fā)生情況、治療前肝腎功能兩兩比較,差異無統(tǒng)計學意義(P0.05),具有可比性。2.兩組治療前中醫(yī)癥候積分組間比較,差異無統(tǒng)計學意義(P0.05)；兩組治療后與治療前比較,癥狀改善明顯,差異有統(tǒng)計學意義(P0.05)；治療組與對照組治療后比較,差異有統(tǒng)計學意義(P0.05)。3.治療組退熱天數(shù)短于對照組,兩組比較,差異有統(tǒng)計學意義(P0.05)。4.兩組治療前白細胞計數(shù)組間比較,差異無統(tǒng)計學意義(P0.05)；兩組治療后與治療前比較,白細胞計數(shù)提升明顯,差異有統(tǒng)計學意義(P0.05)；治療組與對照組治療后比較,差異有統(tǒng)計學意義(P0.05)。5.兩組治療前血小板計數(shù)組間比較,差異無統(tǒng)計學意義(P0.05)；治療組治療后與治療前比較,血小板計數(shù)提升明顯,差異有統(tǒng)計學意義(P0.05)；對照組治療后與治療前比較,血小板計數(shù)提升不明顯,差異無統(tǒng)計學意義(P0.05)；治療組與對照組治療后比較,差異無統(tǒng)計學意義(P0.05)。結(jié)論：1.兩組均可改善患者臨床癥狀,但治療組癥狀改善更明顯。2.醒腦靜注射液能更快使登革熱(衛(wèi)氣同病證)患者降溫,在縮短退熱天數(shù)方面優(yōu)于對照組。3.治療組白細胞計數(shù)、血小板計數(shù)提升更高,治療后白細胞計數(shù)、血小板計數(shù)平均值均高于對照組,兩組治療后兩項指標數(shù)據(jù)均未超過參考值范圍。4.醒腦靜注射液治療登革熱具有較好的安全性。
[Abstract]:Objective: to observe the effect of Xingnaojing injection (Xingnaojing injection) on patients with dengue fever (Wei Qi syndromes syndrome), and to evaluate the efficacy and safety of Xingnaojing injection through its effect on TCM symptom score, antipyretic days, white blood cell count and platelet count. To provide a clinical reference for the treatment of dengue fever with traditional Chinese medicine. Methods: 54 cases of dengue fever were randomly divided into treatment group and control group with 27 cases in each group. The control group was given general symptomatic support therapy: cooling, intravenous and oral rehydration, hemostasis and stomach protection, and the treatment group were treated with Xingnaojing injection 20m intravenous drip once a day for 5 days. When used, 0.9% sodium chloride 250m1 or 5% glucose 250m1 were diluted. Indicators: TCM symptom score, antipyretic days, white blood cell count, platelet count, etc. The difference between the treatment group and the control group before and after treatment and between the control group and the treatment group was compared. The result is 1: 1. There was no significant difference between the two groups in age, sex, rashes, liver and kidney function before treatment, there was no significant difference between the two groups (P 0.05). There was no significant difference in the scores of TCM symptoms between the two groups before treatment, there was no significant difference between the two groups before and after treatment, the symptoms of the two groups were obviously improved after treatment and the difference was statistically significant (P 0.05), and the difference between the treatment group and the control group was statistically significant after treatment. The days of antipyretic in the treatment group was shorter than that in the control group, and the difference between the two groups was statistically significant. There was no significant difference in white blood cell count between the two groups before treatment (P 0.05); after treatment and before treatment, the white blood cell count increased significantly in the two groups, and the difference was statistically significant (P 0.05), while that in the treatment group was higher than that in the control group (P 0.05). The difference was statistically significant (P 0.05). There was no significant difference in platelet count between the two groups before treatment (P 0.05); in the treatment group, the platelet count increased significantly after treatment and before treatment, and the difference was statistically significant (P 0.05); in the control group, it was compared with that before treatment. There was no significant difference in platelet count between the treatment group and the control group (P 0.05). Conclusion 1. Both groups were able to improve the clinical symptoms, but the treatment group was more obvious. 2. 2. Xingnaojing injection can lower the temperature of patients with dengue fever faster than the control group in reducing the days of fever. The leukocyte count and platelet count in the treatment group were higher than those in the control group. After treatment, the mean white blood cell count and platelet count were higher than those in the control group, and the two indexes in both groups did not exceed the reference value range. 4. Xingnaojing injection has good safety in treating dengue fever.
【學位授予單位】：廣州中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

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