本文選題：經(jīng)行頭痛 + 溫經(jīng)養(yǎng)血膏��； 參考：《廣州中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的：經(jīng)行頭痛發(fā)病率高,患者為此所付出的經(jīng)濟(jì)和精神上的代價(jià)也相當(dāng)大,極大影響婦女健康、工作、生活,受到當(dāng)今醫(yī)學(xué)界關(guān)注。但目前關(guān)于經(jīng)行頭痛的發(fā)病機(jī)制尚無(wú)定論,目前中西醫(yī)領(lǐng)域用于經(jīng)行頭痛的治療方案局限性較大,治療方法急需新的突破。所以,探索有效的針對(duì)經(jīng)行頭痛的治療手段具有的臨床意義十分重大。而現(xiàn)代女性貪寒飲冷的生活習(xí)慣易致血虛寒凝經(jīng)行頭痛,針對(duì)血虛寒凝的病機(jī),應(yīng)用具有溫經(jīng)散寒通脈作用的當(dāng)歸四逆湯加減方治療血虛寒凝所致經(jīng)行頭痛切中病機(jī)。鑒于中藥煎煮不便的不足,基于當(dāng)歸四逆湯加減制成溫經(jīng)養(yǎng)血膏,既取膏方無(wú)須煎煮、易存易攜的優(yōu)點(diǎn),又能使當(dāng)歸四逆湯的療效更加溫和持久,尤適合于快節(jié)奏生活的現(xiàn)代女人,確保了患者的依從性。本課題通過(guò)進(jìn)行前瞻、隨機(jī)對(duì)照臨床試驗(yàn)研究來(lái)評(píng)價(jià)和比較溫經(jīng)養(yǎng)血膏與安慰劑對(duì)照方案對(duì)于經(jīng)行頭痛的有效性,為臨床治療經(jīng)行頭痛提供更為方便有效的方案。方法：本研究采用前瞻性隨機(jī)對(duì)照臨床試驗(yàn)研究方法,按照病例納入標(biāo)準(zhǔn),選擇廣東省中醫(yī)院門(mén)診符合納入標(biāo)準(zhǔn)的輕至中度型血虛寒凝型經(jīng)行頭痛病例38例,各病人隨機(jī)分為治療組23例、對(duì)照組15例,以溫經(jīng)養(yǎng)血膏作為試驗(yàn)藥物,選不含藥物成分的膠囊安慰劑作為空白對(duì)照藥物。治療組服藥方法為經(jīng)期第五天開(kāi)始口服,20ml, qd,連續(xù)服用3個(gè)月,對(duì)照組服藥方法為經(jīng)期第五天開(kāi)始口服,2粒,tid,連續(xù)服用3個(gè)月。治療過(guò)程中,對(duì)照組病例脫落1例,病例最終完成收集37例。其中治療組23例,對(duì)照組14例。通過(guò)對(duì)治療前、后,治療組及對(duì)照組的頭痛VAS評(píng)分、頭痛指數(shù)、中醫(yī)證候評(píng)分、五羥色胺、前列腺素F2α、前列腺素E2來(lái)綜合評(píng)價(jià)溫經(jīng)養(yǎng)血膏對(duì)血虛寒凝型經(jīng)行頭痛的療效。結(jié)果：1.經(jīng)行頭痛指數(shù)治療有效率方面,治療組的總有效率87%；對(duì)照組的總有效率21.4%,兩組有效率經(jīng)秩和檢驗(yàn)提示有統(tǒng)計(jì)學(xué)意義(P0.05)。2.經(jīng)行頭痛的中醫(yī)癥狀積分治療有效率方面,治療組的總有效率78.3%；對(duì)照組的總有效率7.1%,兩組有效率經(jīng)秩和檢驗(yàn)提示有統(tǒng)計(jì)學(xué)意義(P0.05)。3.頭痛VAS評(píng)分,治療組治療前、后頭痛指數(shù)差值經(jīng)秩和檢驗(yàn)提示差異有統(tǒng)計(jì)學(xué)意義(P0.05),對(duì)照組治療前、后頭痛指數(shù)經(jīng)秩和檢驗(yàn)提示差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),兩組差值經(jīng)秩和檢驗(yàn)提示有統(tǒng)計(jì)學(xué)意義(P0.05)。4.頭痛指數(shù)評(píng)分,治療組治療前、后頭痛指數(shù)經(jīng)秩和檢驗(yàn)提示有統(tǒng)計(jì)學(xué)意義(P＜0.05),對(duì)照組治療前、后頭痛指數(shù)經(jīng)秩和檢驗(yàn)提示差異無(wú)統(tǒng)計(jì)學(xué)意義(P.05),兩組差值經(jīng)秩和檢驗(yàn)提示有統(tǒng)計(jì)學(xué)意義(P0.05)。5.中醫(yī)的癥狀積分,治療組治療前、后積分經(jīng)秩和檢驗(yàn)提示有統(tǒng)計(jì)學(xué)意義(P0.05),對(duì)照組治療前、后積分經(jīng)秩和檢驗(yàn)提示差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),兩組差值經(jīng)秩和檢驗(yàn)提示有統(tǒng)計(jì)學(xué)意義(P0.05)。6.五羥色胺,兩組治療前后差值經(jīng)秩和檢驗(yàn)提示差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。7.前列腺素F2 α,兩組治療前后差值經(jīng)秩和檢驗(yàn)提示差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。8.前列腺素E2,兩組治療前后差值經(jīng)秩和檢驗(yàn)提示差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論：溫經(jīng)養(yǎng)血膏對(duì)血虛寒凝型經(jīng)行頭痛的VAS評(píng)分及頭痛指數(shù)有明顯改善,同時(shí)對(duì)于伴隨的中醫(yī)證候改善明顯,對(duì)五羥色胺、前列腺素F2 α、前列腺素E2的含量無(wú)明顯改善,溫經(jīng)養(yǎng)血膏治療血虛寒凝型經(jīng)行頭痛未見(jiàn)不良反應(yīng),是臨床上治療本病的有效方法。
[Abstract]:Objective: the incidence of headache is high, and the economic and spiritual cost of the patient is also very high, which greatly affects the health, work and life of women. However, there is no definite conclusion about the pathogenesis of the headache. At present, the treatment scheme for the headache is limited and the treatment is very limited. The law is in urgent need of new breakthroughs. Therefore, it is of great significance to explore effective treatment methods for the menstrual headache. And the cold living habits of modern women are easy to cause blood deficiency and cold coagulating menstrual headache. In view of the pathogenesis of blood deficiency and cold coagulation, the treatment of blood deficiency and cold coagulation with the four inverse Decoction of Angelica sinensis with the effect of warm meridian and cold through pulse is applied to the treatment of blood deficiency and cold coagulation. In view of the inconveniences of headache cutting, in view of the inadequacy of the inconvenience of decocting traditional Chinese medicine, it is based on the reduction of the decoction of Danggui four reverse soup to make the warm blood nourishing cream, not only to take the advantage of decocting, easy to carry, but also to make the curative effect of the four inverse soup of Angelica sinensis more mild and lasting, especially for the modern woman of fast rhythm life, to ensure the compliance of the patient. Prospective, randomized controlled clinical trials to evaluate and compare the effectiveness of Wen Jing Yangxue ointment and placebo control for the menstrual headache and provide a more convenient and effective solution for the clinical treatment of menstrual headaches. Method: This study adopted a prospective randomized controlled clinical trial, and selected the case in Guangdong Province in accordance with the case. 38 cases of mild to moderate blood deficiency and cold coagulating type headache cases were met in the hospital outpatient clinic. The patients were randomly divided into 23 cases in the treatment group and 15 cases in the control group. The control group was treated with Wen Jing Yangxue ointment as the test drug, and the capsules without drug components were selected as the blank control drugs. The treatment group was taken orally for fifth days of menstrual period, 20ml, QD For 3 months, the control group took oral administration for fifth days, 2 grains, TID, and continued to take 3 months. In the course of the treatment, 1 cases were lost in the control group and 37 cases were collected. The treatment group was 23 cases, and the control group was 14. The headache index, headache index, TCM syndrome were passed before treatment, after treatment, treatment group and control group. Score, five hydroxytryptamine, prostaglandin F2 A and prostaglandin E2 were used to evaluate the effect of Wen Jing Yangxue ointment on blood deficiency cold coagulating type headache. Results: 1. the total effective rate of the treatment group was 87%, the total effective rate of the control group was 21.4%, and the two groups of effective rates were statistically significant (P0.05).2. meridian through the rank sum test. The total effective rate of TCM symptoms of headache was 78.3%, the total effective rate of the treatment group was 78.3%, the total effective rate of the control group was 7.1%, and the two groups had a statistical significance (.3.) headache VAS score by rank and test. The difference of the post pain index difference between the treatment group and the control group was statistically significant (P0.05) and the control group was treated before treatment (P0.05). Before treatment, there was no statistical significance (P0.05) with the rank sum test, and the difference value of the two groups was statistically significant (P0.05).4. headache index score. The post pain index was statistically significant before treatment in the treatment group (P < 0.05). Before treatment, the back head pain index was indicated by the rank sum test. The difference was not statistically significant (P.05). The difference between the two groups was statistically significant (P0.05) with statistical significance (P0.05). Before treatment, the post integral was statistically significant (P0.05) by rank sum test (P0.05). There was no statistical significance (P0.05) for the difference between the rank sum test before the treatment of the control group (P0.05), and the difference value was tested by rank sum test. The difference was statistically significant (P0.05).6. five hydroxytryptamine, and the difference between the two groups before and after treatment was not statistically significant (P0.05).7. prostaglandin F2 alpha, and the difference between the two groups before and after treatment was not statistically significant (P0.05).8. prostaglandin E2, and there was no statistical difference between the two groups before and after treatment with no statistical difference. Significance (P0.05). Conclusion: Wen Jing Yangxue ointment improved the VAS score and headache index of blood deficiency cold coagulant type headache, and improved evidently for the accompanying TCM syndrome. There was no obvious improvement on the content of five hydroxytryptamine, prostaglandin F2 A and prostaglandin E2, and there was no adverse reaction in the treatment of blood deficiency and cold coagulating type with headache. It is an effective method for clinical treatment of this disease.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R271.115

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 滕月新;“消痛湯”治療經(jīng)行頭痛86例[J];江蘇中醫(yī);1997年01期

2 周易明;“蠲痛飲”治療經(jīng)行頭痛53例療效觀(guān)察[J];貴陽(yáng)中醫(yī)學(xué)院學(xué)報(bào);1999年04期

3 周易明;“蠲痛飲”治療經(jīng)行頭痛53例療效觀(guān)察[J];新疆中醫(yī)藥;1999年04期

4 劉詩(shī)丹;中西醫(yī)治療經(jīng)行頭痛的研究概況[J];廣西中醫(yī)學(xué)院學(xué)報(bào);2000年02期

5 鐘挹秀,伍蘇迪;經(jīng)行頭痛一案體會(huì)[J];陜西中醫(yī)學(xué)院學(xué)報(bào);2002年05期

6 于水永,管淑彩,范廣巖;中藥治療經(jīng)行頭痛60例[J];光明中醫(yī);2005年06期

7 李傳進(jìn);;淺談經(jīng)行頭痛的證治[J];中國(guó)民間療法;2008年01期

8 王瓊;李平平;盧雪蓮;張慶文;;淺析柴胡疏肝散加減治療經(jīng)行頭痛[J];云南中醫(yī)中藥雜志;2012年09期

9 王莉;凌霞;;導(dǎo)師凌霞教授治療經(jīng)行頭痛經(jīng)驗(yàn)總結(jié)[J];中國(guó)實(shí)用醫(yī)藥;2013年06期

10 徐娟;;鄧高丕教授治療經(jīng)行頭痛的經(jīng)驗(yàn)擷菁[J];新中醫(yī);2013年07期

相關(guān)重要報(bào)紙文章 前7條

1 河北省石家莊市華光中醫(yī)腫瘤醫(yī)院 方玉紅 苗永華 整理;經(jīng)行頭痛方[N];中國(guó)中醫(yī)藥報(bào);2014年

2 時(shí)立新;不容忽視的經(jīng)行頭痛[N];中國(guó)中醫(yī)藥報(bào);2007年

3 樂(lè)秀珍 教授;經(jīng)行頭痛怎么辦？[N];上海中醫(yī)藥報(bào);2006年

4 黎緯武;經(jīng)行頭痛試試疏肝活血湯[N];大眾衛(wèi)生報(bào);2005年

5 韋金香;壯醫(yī)藥線(xiàn)點(diǎn)灸治療經(jīng)行頭痛68例[N];民族醫(yī)藥報(bào);2005年

6 李宇俊;經(jīng)行頭痛的中醫(yī)治療[N];中國(guó)中醫(yī)藥報(bào);2001年

7 張洪軍;婦女經(jīng)行頭痛的中醫(yī)施治[N];中國(guó)中醫(yī)藥報(bào);2004年

相關(guān)博士學(xué)位論文 前2條

1 邱瓊瑩;小柴胡湯加減治療經(jīng)行頭痛的規(guī)律研究[D];南京中醫(yī)藥大學(xué);2007年

2 朱鴻秋;雌二醇導(dǎo)致經(jīng)行頭痛的實(shí)驗(yàn)及經(jīng)輕膠囊干預(yù)機(jī)制初探[D];成都中醫(yī)藥大學(xué);2005年

相關(guān)碩士學(xué)位論文 前8條

1 林少僑;溫經(jīng)養(yǎng)血膏治療血虛寒凝型經(jīng)行頭痛的臨床研究[D];廣州中醫(yī)藥大學(xué);2016年

2 徐麗;補(bǔ)血疏肝湯治療經(jīng)行頭痛（肝郁腎虛證）的臨床觀(guān)察[D];長(zhǎng)春中醫(yī)藥大學(xué);2012年

3 吳國(guó)賢;小柴胡湯治療經(jīng)行頭痛的臨床研究[D];廣州中醫(yī)藥大學(xué);2009年

4 李靜;導(dǎo)師陳瑩教授治療經(jīng)行頭痛經(jīng)驗(yàn)總結(jié)[D];遼寧中醫(yī)藥大學(xué);2011年

5 呂艷芳;黃可佳教授治療經(jīng)行頭痛的經(jīng)驗(yàn)總結(jié)[D];遼寧中醫(yī)藥大學(xué);2013年

6 呂文靜;頭穴透刺配合體針治療經(jīng)行頭痛臨床觀(guān)察[D];黑龍江中醫(yī)藥大學(xué);2014年

7 劉芳榮;針灸治療經(jīng)行頭痛的臨床研究[D];廣州中醫(yī)藥大學(xué);2009年

8 林純潔;加減通竅活血湯治療血瘀型經(jīng)行頭痛的臨床觀(guān)察[D];廣州中醫(yī)藥大學(xué);2014年

，

本文編號(hào)：2043575