發(fā)布時(shí)間：2018-06-12 21:42

  本文選題：清燥布津法 + 干燥綜合征��； 參考：《山東中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:基于“燥毒學(xué)說(shuō)”,闡明清燥布津法治療干燥綜合征(Sj?gren syndrome,SS)的理論依據(jù),通過(guò)實(shí)驗(yàn)研究與臨床研究相結(jié)合的方法,探討清燥布津法治療干燥綜合征具有重要的理論與臨床意義。方法:臨床研究:將61例符合干燥綜合征診斷標(biāo)準(zhǔn)患者采用隨機(jī)數(shù)表法分組,隨機(jī)分為清燥布津合劑試驗(yàn)組(QZBJ組)和硫酸羥氯喹對(duì)照組(HCQ組),QZBJ組31人,HCQ組30人。試驗(yàn)組給予清燥布津合劑治療16周;對(duì)照組給予硫酸羥氯喹片口服治療16周。比較試驗(yàn)組與對(duì)照組的臨床療效,并評(píng)價(jià)其安全性。實(shí)驗(yàn)研究:通過(guò)實(shí)驗(yàn)驗(yàn)證清燥布津合劑對(duì)干燥綜合征BALB/c小鼠唾液分泌及相關(guān)細(xì)胞因子的影響。結(jié)果:臨床研究:清燥布津合劑組顯效5例,有效16例,改善6例,無(wú)效3例,總有效率為90%;羥氯喹組顯效2例,有效8例,改善18例,無(wú)效7例,總有效率為76.67%。清燥布津合劑組效果優(yōu)于羥氯喹組。清燥布津合劑組、羥氯喹組組內(nèi)治療前后在口干、眼干、皮膚干燥、大便干燥等癥狀評(píng)分、血沉、免疫球蛋白(IgG、IgM、IgA)、疾病活動(dòng)度評(píng)價(jià)、患者主觀評(píng)價(jià)均有不同程度的改善,組內(nèi)治療前后存在顯著差異,結(jié)果具有統(tǒng)計(jì)學(xué)意義(P㩳0.05),說(shuō)明清燥布津合劑與羥氯喹在治療干燥綜合征方面都有療效;清燥布津合劑組與羥氯喹組組間治療后在口干、眼干、皮膚干燥、大便干燥等癥狀評(píng)分、血沉、免疫球蛋白(IgG、IgM、IgA)、患者主觀評(píng)價(jià)均有不同程度的改善,組間治療后存在顯著差異,結(jié)果具有統(tǒng)計(jì)學(xué)意義(P㩳0.05),說(shuō)明清燥布津合劑組總體療效優(yōu)于羥氯喹組。實(shí)驗(yàn)研究:清燥布津合劑可以改善小鼠口干癥狀、唾液分泌量、對(duì)干燥綜合征BALB/c小鼠模型Th平衡相關(guān)細(xì)胞因子具有調(diào)節(jié)作用。結(jié)論:臨床研究顯示清燥布津法治療干燥綜合征可以有效緩解患者口干、眼干等臨床癥狀,并且治療過(guò)程安全有效,是治療干燥綜合征的有效方法之一。實(shí)驗(yàn)研究顯示能顯著改善干燥綜合征BALB/c模型小鼠病理狀態(tài),抑制干燥綜合征相關(guān)炎性細(xì)胞因子,其機(jī)理可能是通過(guò)調(diào)節(jié)其免疫功能實(shí)現(xiàn)的。為清燥布津法治療干燥綜合征提供科學(xué)依據(jù),有利于指導(dǎo)干燥綜合征的臨床實(shí)踐。
[Abstract]:Objective: based on the theory of dryness and toxin, to clarify the theoretical basis for the treatment of Sjjgren syndrome SSs with the method of clearing dryness and Bujin, and to combine the experimental study with clinical research. It is of great theoretical and clinical significance to explore the treatment of Sjogren syndrome by clearing dryness and bujin. Methods: 61 patients with Sjogren's syndrome were randomly divided into QZBJ group (QZBJ group) and HCQ group (31 patients in HCQ group) and 30 patients in HCQ group. The experimental group was treated with Qingzao Bujin mixture for 16 weeks and the control group with hydroxychloroquine sulfate tablets for 16 weeks. To compare the clinical efficacy between the experimental group and the control group, and to evaluate its safety. Experimental study: the effects of Qingzao Bujin mixture on saliva secretion and related cytokines in BALB / P / c mice with Sjogren's syndrome were studied. Results: clinical study: in Qingzao Bujin mixture group, 5 cases were effective, 16 cases were effective, 6 cases were improved, 3 cases were ineffective, the total effective rate was 90 cases, in hydroxychloroquine group, there were 2 cases of remarkable effect, 8 cases of effective effect, 18 cases of improvement, 7 cases of ineffectiveness, and 76.67% of total effective rate. The effect of Qingzao Bujin mixture group was better than that of hydroxychloroquine group. The scores of dry mouth, dry eyes, dry skin, dry stool, erythrocyte sedimentation rate, immunoglobulin IgGG, IgM, disease activity, subjective evaluation of patients were improved in the treatment group of Qingzao Bujin mixture and hydroxychloroquine before and after treatment. There was significant difference between the two groups before and after treatment. The results showed that Qingzao Bujin mixture and hydroxychloroquine were effective in the treatment of Sjogren syndrome, and the dry mouth and eyes were dry after treatment between Qingzaobujin mixture group and hydroxychloroquine group. The scores of dry skin, dry stool and other symptoms, ESR, IgGG and IgMU IgA, the subjective evaluation of the patients were improved to some extent, and there were significant differences between the two groups after treatment. The results showed that the total curative effect of Qingzao Bujin mixture group was better than that of hydroxychloroquine group. Experimental study: Qingzao Bujin mixture can improve the dry mouth symptoms, saliva secretion, and regulate the Th balance of cytokines in Sjogren syndrome BALB- c mice model. Conclusion: the clinical study shows that the treatment of Sjogren's syndrome with Qingzao Bujin method can effectively relieve the clinical symptoms such as dry mouth and dry eye, and the treatment process is safe and effective. It is one of the effective methods for the treatment of Sjogren's syndrome. The experimental results showed that it could significantly improve the pathological state of BALB / c mice model of Sjogren's syndrome and inhibit the inflammatory cytokines associated with Sjogren's syndrome. The mechanism may be achieved by regulating the immune function of Sjogren's syndrome mice. It provides a scientific basis for the treatment of Sjogren syndrome with the method of clearing dryness and Bujin, and is helpful to guide the clinical practice of Sjogren syndrome.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R259

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 陸安康;;中西醫(yī)結(jié)合治療干燥綜合征18例[J];實(shí)用中醫(yī)內(nèi)科雜志;2002年03期

2 梁忠合,王雅珍;9例干燥綜合征的診治體會(huì)[J];臨床醫(yī)藥實(shí)踐;2003年06期

3 李慧妍;干燥綜合征延誤診治1例[J];現(xiàn)代口腔醫(yī)學(xué)雜志;2003年05期

4 鄭文軍,林有坤,嚴(yán)煜林,梁伶;干燥綜合征致急性造血功能停滯一例[J];中華皮膚科雜志;2004年01期

5 袁秀亭;干燥綜合征誤診為血小板減少性紫癜11例分析[J];首都醫(yī)藥;2004年08期

6 王麗春,劉真真,馬元吉,呂曉菊,雷秉鈞;以繼發(fā)感染為首發(fā)表現(xiàn)的干燥綜合征1例分析[J];中國(guó)誤診學(xué)雜志;2005年07期

7 張?zhí)煊?葛波,覃展偶,滕若冰;干燥綜合征侵犯睪丸一例[J];華夏醫(yī)學(xué);2005年06期

8 梁素梅;常虹;周軍;;抗-HCV陽(yáng)性合并干燥綜合征誤診39例[J];河南科技大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2005年04期

9 劉玉林;韓月仙;張步強(qiáng);孫瑞蘭;索紅楓;溫鴻雁;;以發(fā)熱為主要表現(xiàn)的原發(fā)干燥綜合征誤診為肺結(jié)核3例分析[J];臨床醫(yī)藥實(shí)踐;2006年10期

10 王翠香;;干燥綜合征46例護(hù)理體會(huì)[J];齊魯護(hù)理雜志;2006年21期

相關(guān)會(huì)議論文 前10條

1 史旭華;高麗霞;張奉春;張p，

本文編號(hào)：2011183