本文選題：阿爾茨海默病 + 脾虛痰阻型��； 參考：《廣西中醫(yī)藥大學》2017年碩士論文

【摘要】：目的:通過觀察加味溫脾通絡開竅方對脾虛痰阻型阿爾茨海默病治療后的臨床療效,評估其有效性及安全性。方法:將符合納入標準的60例脾虛痰阻型阿爾茨海默病患者采用隨機對照試驗方法分為治療組(30例)和對照組(30例),其中,治療組在口服鹽酸多奈哌齊片基礎上聯(lián)合加味溫脾通絡開竅方治療,對照組僅口服鹽酸多奈哌齊片治療。觀察兩組患者在治療前和治療兩個月后的簡易智能量表(MMSE)、日常生活活動能力量表(ADL)的評分變化,及中醫(yī)癥狀積分變化情況,評定其臨床療效。結果:(1)治療組的臨床總有效率為84.6%,對照組的臨床總有效率為70.4%,兩種干預措施均有療效,且治療組的有效率高于對照組(P0.05);(2)治療后,治療組的MMSE平均評分為24.54±2.23分,對照組的MMSE平均評分為22.93±2.83分,治療組的MMSE平均評分高于對照組(P0.05);(3)治療后,治療組的ADL平均評分為35.04±5.88分,對照組的平均評分為38.11±5.17分,治療組的ADL平均評分低于對照組(P0.05);(4)治療后,兩組患者中醫(yī)癥狀積分變化情況比較,治療組在改善智能減退、頭昏身重、納呆嘔惡、氣短懶言、面黃便溏癥狀方面優(yōu)于對照組(P0.05);(5)治療組患者用藥后無明顯毒副作用。結論:加味溫脾通絡開竅方治療脾虛痰阻型阿爾茨海默病臨床療效顯著,改善患者的認知功能,且無明顯副作用,安全可靠。
[Abstract]:Objective: to evaluate the efficacy and safety of Jiawei Wenpi Tongluo Kaiqiao recipe in treating Alzheimer's disease with spleen deficiency and phlegm obstruction. Methods: sixty cases of Alzheimer's disease with spleen deficiency and phlegm obstruction were divided into two groups: treatment group (n = 30) and control group (n = 30). The treatment group was treated with Jiawei Wenpi Tongluo Kaiqiao decoction on the basis of oral Donepezil Hydrochloride tablets, while the control group was only treated with Donepezil Hydrochloride tablet. To observe the scores of MMSE and ADL before treatment and two months after treatment, and to evaluate the clinical efficacy of the two groups. Results the total effective rate was 84.6 in the treatment group and 70.4 in the control group. The two kinds of intervention measures were effective, and the effective rate in the treatment group was higher than that in the control group (P 0.05). After treatment, the average score of MMSE in the treatment group was 24.54 鹵2.23. The average score of MMSE in the control group was 22.93 鹵2.83. The average score of MMSE in the treatment group was higher than that in the control group (P 0.05). After treatment, the average score of ADL in the treatment group was 35.04 鹵5.88, and the average score in the control group was 38.11 鹵5.17. The average score of ADL in the treatment group was lower than that in the control group after treatment. Comparing the changes of TCM symptom score between the two groups, the treatment group had no obvious side effects after treatment. The patients in the treatment group were better than those in the control group in improving their intelligence, dizziness, nausea, shortness of breath, slackness of breath, loose stools, and loose stools in the control group. Conclusion: Jiawei Wenpi Tongluo Kaiqiao recipe has a significant clinical effect in treating Alzheimer's disease with spleen deficiency and phlegm obstruction. It can improve the cognitive function of the patients without obvious side effects and is safe and reliable.
【學位授予單位】：廣西中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R277.7

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